Biophysical Society 65th Annual Meeting Program Guide

121-Pos B oard B55 STRUCTURE PREDICTION OF THE TRANSMEMBRANE REGION OF AL- PHA- AND BETA- SECRETASES USING REPLICA-EXCHANGE MOLECULAR DYNAMICS SIMULATIONS, AND THE INTERACTION BETWEEN AMYLOID PRECURSOR PROTEIN AND THEM. Kaori Yanagino , Naoyuki Miyashita 122-Pos B oard B56 WORKING TOWARDS CRYO-EM STRUCTURES OF MITOCHONDRIAL DYNAMIN-LIKE GTPASES. Melissa R. Mikolaj , Sarah Nyenhuis, Jenny E. B oard B57 MODELLING LONG LOOPS OF MEMBRANE PROTEINS USING PRET- ZEL. Manisha Barse , Alan Perez-Rathke, Jie Liang 124-Pos B oard B58 MOLECULAR MECHANISM OF POTASSIUM (K + ) ION SENSING HISTIDINE KINASE INVOLVED IN BIOFILM FORMATION. Rachael M. Lucero , Randy Stockbridge 125-Pos B oard B59 INVESTIGATING SARS-COV-2 ORF7B HOMODIMERIZATION BY MOLECU- LAR DYNAMICS SIMULATIONS. Min-Kang Hsieh , Jeffery B. Klauda 126-Pos B oard B60 INTERPLAY BETWEEN LEAKAGE AND FUSION OF PHOSPHATIDYLCHO- LINE LIPOSOMES INDUCED BY THE MACROLITTINS, A SYNTHETICALLY EVOLVED FAMILY OF PORE-FORMING PEPTIDES. Leisheng Sun , Kalina Hristova, William C. Wimley 127-Pos B oard B61 DECIPHERING THE ROLES OF YERSINIA PESTIS OUTER MEMBRANE PRO- TEINS IN THEIR NATIVE ENVIRONMENT. James E. Kent , Lynn M. Fujimoto, Kyungsoo Shin, Chandan Singh, Yong Yao, Gregory V. Plano, Francesca M. B oard B62 STRUCTURAL INSIGHTS AND CLASSIFICATION OF THE DISEASE-CAUSING MUTATIONS IN HUMAN NA + - COUPLED CITRATE TRANSPORTER (NACT) USING A HOMOLOGY MODELING APPROACH. Valeria Jaramillo-Martinez , Vadivel Ganapathy, Ina Urbatsch 129-Pos B oard B63 RATIONAL DESIGN OF SMALL MOLECULAR GLP-1R AGONISTS. Zixin Yang , Zhengkun Kuang, Rui Wang, Ni Pi, Xiyao Cheng, Yongqi Huang, Zhengding Su 130-Pos B oard B64 MODULATION OF THE ACYLATION OF THE C-TERMINAL SEGMENT OF GRK1 DRASTICALLY INFLUENCES ITS SOLUBILITY AND MEMBRANE- BINDING PROPERTIES. Marc-Antoine Millette , Camille Gagnon, Christian Salesse 131-Pos B oard B65 COMPARING THE DYNAMIC DIFFERENCES BETWEEN X-RAY AND CRYO- EM STRUCTURES OF CANNABINOID RECEPTOR 1 USING MOLECULAR DYNAMICS SIMULATIONS. Ugochi Isu , Vivek Govind Kumar, Adithya Polasa, Mahmoud Moradi Intrinsically Disordered Proteins (IDP) and Aggregates I (Boards B66 - B87) 132-Pos B oard B66 REENTRANT LIQUID CONDENSATE PHASE OF PROTEINS IS STABILIZED BY HYDROPHOBIC AND NON-IONIC INTERACTIONS. Georg Krainer , Timothy J. Welsh, Jerelle A. Joseph, Peter St George-Hyslop, Anthony A. Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas P.J. Knowles Hinshaw 123-Pos Marassi 128-Pos

133-Pos B oard B67 CHARACTERIZING STRUCTURAL AND DYNAMIC FEATURES OF SOLUBLE IAPP OLIGOMERS. Bryan A. Bogin , Zachary Levine 134-Pos B oard B68 A 4BPA COARSE-GRAINED MOLECULAR DYNAMICS STUDY ON THE AG- GREGATION OF POLYGLUTAMINE. Mark van der Klok , Maurice Dekker, Erik Van der Giessen, Patrick R. Onck 135-Pos B oard B69 DOXORUBICIN INDUCES ABERRANT SELF-ASSEMBLY OF P53 BY PHASE SEPARATION. Ankush Garg , Sharmistha Sinha 136-Pos B oard B70 THERMODYNAMIC STABILITY OF HNRNP A1 LOW COMPLEXITY DOMAIN REVEALED BY HIGH-PRESSURE NMR. Jeffrey D. Levengood, Jake Peterson, Blanton S. Tolbert, Julien Roche 137-Pos B oard B71 HOW DO EVOLUTIONARILY ENCODED COMPOSITIONAL BIASES INFLU- ENCE THE PHASE BEHAVIORS OF INTRINSICALLY DISORDERED LOW COMPLEXITY DOMAINS OF PROTEINS? Mina Farag , Anne Bremer, Wade Borcherds, Tanja Mittag, Rohit V. Pappu 138-Pos B oard B72 EFFECTS OF MEMBRANE CURVATURE ON AMYLOID-BETA AGGREGA- TION. Abhilash Sahoo 139-Pos B oard B73 BOTTOM-UP COARSE-GRAINED MODELS FOR INTRINSICALLY DISOR- DERED PROTEINS. Thomas P. Dannenhoffer-Lafage , Robert B. Best 140-Pos B oard B74 QUANTIFICATION OF THE ONSET OF CONDENSATION IN NEGATIVE ELONGATION FACTORS. Chenyang Lan , Prashant Rawat, Ritwick Sawarkar, Thorsten Hugel 141-Pos B oard B75 DE NOVO COMPUTATIONAL DESIGN OF DISORDERED FG-NUCLEOPO- RINS. Henry de Vries , Alessio Fragasso, Tegan Otto, Nils Klughammer, John Andersson, Eli van der Sluis, Anton Steen, Andreas Dahlin, Liesbeth Veenhoff, Cees Dekker, Erik Van der Giessen, Patrick Onck 142-Pos B oard B76 INTEGRATING NMR, SAXS AND SINGLE-MOLECULE FRET DATA TO INFER CONFORMATIONAL ENSEMBLES OF THE YEAST SIC1 PROTEIN. Claudiu C. Gradinaru , Gregory W. Gomes, Tanja Mittag, Teresa L. Head-Gordon, Julie D. Forman-Kay 143-Pos B oard B77 EFFECTS OF FAMILIAL MUTATION AND C-TERMINAL TRUNCATION ON NUCLEATION AND FIBRIL ELONGATION OF Α-SYNUCLEIN. Takashi Ohgita , Norihiro Namba, Hiroki Kono, Hiroyuki Saito 144-Pos B oard B78 REAL-TIME OBSERVATION OF STRUCTURAL AND DYNAMICAL CHANGES OF THE FUS LOW-COMPLEXITY DOMAIN DURING LIQUID-TO-SOLID PHASE TRANSITIONS. Raymond F. Berkeley , Maryam Kashefi, Galia T. Debelouchina 145-Pos B oard B79 ENVIRONMENT DEPENDENT SECONDARY STRUCTURE OF A RIBOSOME STALLING PEPTIDE. Gabor Nagy , Michal H. Kolar, John D. Kunkel, Sara M. Vaiana, Helmut Grubmuller 146-Pos B oard B80 PROBING THE INTERACTIONS OF INTRINSICALLY DISORDERED PROTEIN WITH METAL IONS AND LIPID MEMBRANES BY FLUORESCENCE SPEC- TROSCOPY. Xiangyu Teng , Keith Willison, Liming Ying

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