Biophysical Society 65th Annual Meeting Program Guide

409-Pos B oard B343 COMPARISON OF DEEP LEARNING MODELS FOR FULLY AUTOMATED SINGLE CHANNEL IDEALIZATION. Sam Ball , Numan Celik, Nathanael O’Neill, Fiona O’Brien, Richard Barrett-Jolley 410-Pos B oard B344 VESPER: GLOBAL AND LOCAL CRYO-EMMAP ALIGNMENT AND DATA- BASE SEARCH USING LOCAL DENSITY VECTORS. Genki Terashi , Xusi Han, Charles Christoffer, Siyang Chen, Daisuke Kihara 411-Pos B oard B345 MONTE CARLO PATHWAY SEARCH (MCPS) FOR EXPLORING PERMEATION PATHWAYS IN HIGH-DIMENSIONAL CONFORMATIONAL SPACE. Archit K. Vasan , Nandan Haloi, Po-Chao Wen, Emad Tajkhorshid 412-Pos B oard B346 PREDICTING EPITHELIAL-MESENCHYMAL TRANSITION DYNAMICS UNDER SPECIFIC PERTURBATIONS USING DATA ASSIMILATION. Mario J. Mendez , Matthew J. Hoffman, Elizabeth M. Cherry, Christopher A. Lemmon, Seth H. Weinberg 413-Pos B oard B347 CAN COMPLETE TRANSPORTER MECHANISMS BE INFERRED FROM EXPERIMENTAL DATA? August George , Nathan E. Thomas, Katherine A. Henzler-Wildman, Daniel M. Zuckerman 414-Pos B oard B348 INTEGRATING MOLECULAR DYNAMICS AND SMFRET DATA TO STUDY THE CONFORMATIONAL ENSEMBLE OF THE C-TERMINUS OF ALBINO3 PROTEIN. James Losey , Vivek Govind Kumar, Dustin Baucom, Mercede Furr, Colin D. Heyes, Suresh Kumar, Mahmoud Moradi 415-Pos B oard B349 USING THE ENTROPY OF NON-EQUILIBRIUM SYSTEMS OF MOLECULES TO ESTIMATE THE INTERACTION MATRIX IN GRAPHICAL GAUSSIAN MODELS OF OMICS DATA. Ahmad Borzou , Rovshan G. Sadygov 416-Pos B oard B350 QUANTITATIVE SPATIAL LOCALIZATION OF BIOMOLECULES FROM FLUO- RESCENCE MICROSCOPY DATA. AndrewM. Soltisz , Rengasayee Veer- araghavan Bioengineering (Boards B351 - B367) 417-Pos B oard B351 SINGLE-STEP, SINGLE-COLUMN PROTEIN PURIFICATION AND LABELLING FOR FLUORESCENCE STUDIES. Arvi Puka , Adrian Rotaru, Spencer Smyth, Andrew Beharry, Claudiu C. Gradinaru 418-Pos B oard B352 NEAR-INFRARED FLOURESCENCE PROBES FOR VISUALIZATION OF TUMORS AND BLOOD VESSELS. Michael DuPont , Troy Crawford, Anna Moshnikova, Dhammika Weerakkody, Yana K. Reshetnyak, Oleg A. An- dreev, John Shen 419-Pos B oard B353 DEEP LEARNING IMAGE ANALYSIS MODEL OF PULMONARY ARTERIES. Erica Pursell , Yasser Aboelkassem 420-Pos B oard B354 FIBRIN MOLECULAR STRUCTURE INDUCED BY SHEAR AND TENSION ME- CHANICAL STIMULI CAN BE A KEY FOR FIBRINOLYSIS. Yujen Wang , Sachin Kumar B, Mischa Bonn, Sapun H. Parekh 421-Pos B oard B355 CALMODULINOPATHY CORRECTION USING CRISPR INTERFERENCE IN A CARDIAC MICROTISSUE MODEL. Chenyu Huang , Chin Siang Ong, Jingnan Han, Joseph Boktor, Roald Teuben, Ijala Wilson, Deborah DiSilvestre, Leslie Tung, Narutoshi Hibino, Daniel H. Reich, Gordon F. Tomaselli

422-Pos B oard B356 APPLICATION OF NEXT-GENERATION SEQUENCING ANALYSIS IN THE DIRECTED EVOLUTION FOR CREATING ANTIBODY MIMIC. Tomoyuki Ito , Hafumi Nishi, Thuy Duong Nguyen, Yutaka Saito, Tomoshi Kameda, Hikaru Nakazawa, Koji Tsuda, Mitsuo Umetsu 423-Pos B oard B357 SYNTHESIZING LONG AND REPETITIVE PROTEINS VIA A “LOOPABLE TRANSLATOR” SYSTEM. Sea On Lee , Stephen D. Fried 424-Pos B oard B358 ENGINEERING OF GENOME EDITING PROTEIN CAS9 THAT SLIDES ALONG DNA FASTER AND MIGHT ENABLE EFFICIENT TARGET SEARCH. Trishit Banerjee , Dwiky Rendra Graha Subekti, Hiroto Takahashi, Satoshi Taka- hashi, Kiyoto Kamagata 425-Pos B oard B359 MATHEMATICAL MODELS FOR LIVING FORMS IN MEDICAL PHYSICS SUBMODEL 2: INFORMATION CODING AND INFORMATION PROCESSING THROUGH NERVES. Christina Pospisil 426-Pos B oard B360 MEASURING AND OPTIMIZING MG-63 OSTEOSARCOMA OSSEOINTE- GRATION AND PROLIFERATION ON LASER ABLATED MEDICAL-GRADE TITANIUM. Tara T. Hickman 427-Pos B oard B361 CELL PHENOTYPE DETERMINATION ON HYDROGEL SUBSTRATES USING RAMAN SPECTROSCOPY AND MULTIVARIATE ANALYSIS. Apurva Godbole , Sayani Majumdar, Isamar O. Pastrana, Brittney L. Gorman, Mary L. Kraft 428-Pos B oard B362 BIOENGINEERING THE EXTRACELLULAR MATRIX TO IMPROVE THE CEL- LULAR AND MOLECULAR PHYSIOLOGY OF CELLS IN VITRO. Hamed Ghazizadeh , Elliot C. Fisher, Kevin Gray, Alec S. Smith, Deok-Ho Kim, Nicholas Geisse 429-Pos B oard B363 LIPID COMPOSITION OF THE CELL MEMBRANE OUTER LEAFLET AFFECTS ENDOCYTOSIS AND INTRACELLULAR FATE OF NANOPARTICLES. Saeed Nazemidashtarjandi , Monica Burdick, Amir Farnoud 430-Pos B oard B364 INHIBITION OF SARS-COV-2 SPIKE PROTEIN FUNCTION BY AMPHIPHILIC BLOCK COPOLYMERS. Michelle X. Ling , Michelle Nguyen, Kyle McCollum, Raphael C. Lee 431-Pos B oard B365 ENGINEERING CRYSTALLINE PROTEIN ARRAYS FOR FUNCTIONALIZED 2D AND 3D BIOMATERIALS. Behzad Rad , Caroline M. Ajo-Franklin, Francesca Manea, Virginia G. Garda 432-Pos B oard B366 SOLID TUMOR CURES BY COMPLETE DISRUPTION OF THE CD47:SIRPΑ MACROPHAGE CHECKPOINT, TUMOR OPSONIZATION, AND ‘PHAGOCYTIC FEEDBACK’. Lawrence J. Dooling , Jason C. Andrechak, Brandon H. Hayes, Siddhant Kadu, Ruby Pan, Michael P. Tobin, Manasvita Vashisth, Dennis E. B oard B367 PH RESPONSIVE UPCONVERSION MESOPOROUS SILICA NANOPAR- TICLES FOR TARGETED PHOTODYNAMIC AND PHOTOTHERMAL CANCER THERAPY. Palanikumar Loganathan , Mazin M. Magzoub Discher 433-Pos

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