Biophysical Society 65th Annual Meeting Program Guide

Platform Protein Dynamics and Allostery I 10:00 am - 11:30 am

Wednesday, February 24

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General Networking 9:00 am-10:00 am

Chair Judith Klinman, University of California, Berkeley, USA 480-Plat 10:00 am

Catch up with colleagues and friends in the biophysical community during our networking hour. This event, which is open to all meeting attendees, provides meet-and-greet opportunities to enhance your virtual meeting experience. Symposium Best of Biophysical Journal : Genomes to Populations 10:00 am - 11:30 am Chair Jane Dyson, Scripps Research Institute, USA No Abstract 10:00 am X-RAY STRUCTURAL ANALYSIS OF SINGLE ADULT CARDIOMYOCYTES: TOMOGRAPHIC IMAGING AND MICRODIFFRACTION. Tim Salditt No Abstract 10:22 am DIFFERENT VINCULIN BINDING SITES USE THE SAME MECHANISM TO REGULATE DIRECTIONAL FORCE TRANSDUCTION. Viola Vogel No Abstract 10:44 am DYNAMIC CROWDING REGULATES TRANSCRIPTION. Igal Szleifer No Abstract 11:06 am DIFFERENTIAL LOCAL STABILITY GOVERNS THE METAMORPHIC FOLD SWITCH OF BACTERIAL VIRULENCE FACTOR RFAH. Cesar Ramirez- Sarmiento Platform Protein Structure and Conformation: Folding 10:00 am - 11:30 am Chair Roland Winter, TU Dortmund University, Germany 475-Plat 10:00 am TEMPERATURE, PRESSURE, AND COSOLUTE EFFECTS ON LIQUID-LIQUID PHASE SEPARATION IN PROTEIN CONDENSATES: PHYSICAL CHEMISTRY AND BIOLOGICAL IMPLICATIONS. Roland Winter 476-Plat 10:30 am CONFORMATIONAL PLASTICITY OF THE CLPAP AAA+ PROTEASE COUPLES PROTEIN UNFOLDING AND PROTEOLYSIS. Alexandrea N. Rizo , Kyle Eric Lopez, James Shorter, Daniel R. Southworth 477-Plat 10:45 am ELECTRICAL UNFOLDING OF CYTOCHROME C DURING TRANSLOCATION THROUGH A NANOPORE CONSTRICTION. Prabhat Tripathi , Abdelkrim Benabbas, Behzad Mehrafrooz, Hirohito Yamazaki, Aleksei Aksimentiev, Paul M. Champion, Meni Wanunu 478-Plat 11:00 am A NOVEL APPROACH COMBINING FLUORESCENCE-ANISOTROPY DECAYS AND MICROVISCOMETRY TO EXPLORE THE COTRANSLATIONAL COM- PACTION OF NASCENT PROTEINS. Rachel Hutchinson , Xi Chen, Ningkun Zhou, Silvia Cavagnero 479-Plat 11:15 am SHORT ARGININE-BASED PEPTIDES AS PREDICTORS FOR THE EXTENDED STRUCTURE OF POLYARGININE SEQUENCES IN INTRINSICALLY DISOR- DERED PROTEINS. Bridget Milorey , Reinhard Schweitzer-Stenner, Brian Andrews, Harald Schwalbe, Brigita Urbanc

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EMERGING EXPERIMENTAL PROBES FOR THE SPATIAL AND TEMPORAL RESOLUTION OF PROTEIN DYNAMICS IN ENZYME CATALYSIS. Judith Klinman , Shuaihua Gao, Emily J. Thompson, Jan Paulo Zaragoza 481-Plat 10:30 am HDXMS REVEALS THE ROLE OF DYNAMICS ON THE SERINE PROTEASE ACTIVITY OF THE UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA). Constanza Torres-Paris , Lufan Xiao, Harriet Song, Elizabeth A. Komives 482-Plat 10:45 am ESSENTIAL DYNAMICS THAT DRIVE SARS-COV-2 SPIKE CONFORMATIONAL CHANGES. Srirupa Chakraborty , Rachael A. Mansbach, Kien Nguyen, Pedro D. Manrique, Sandrasegaram Gnanakaran 483-Plat 11:00 am DIRECT OBSERVATION OF THE CATALYTICALLY RELEVANT FULLY FOLDED- LOCALLY UNFOLDED EQUILIBRIUM IN PEROXIREDOXIN Q OF XANTHAMO- NAS CAMPESTRIS. Aidan Estelle , Patrick N. Reardon, Andrew Karplus, Elisar J. Barbar 484-Plat 11:15 am COMBINING SINGLE-MOLECULE FLUORESCENCE AND MD-SIMULATIONS TO DELINEATE THE KINETICS AND REGULATION OF PROTEINS. Thorsten Hugel , Sonja Schmid, Steffen Wolf, Bjoern Hellenkamp, Benedikt Sohmen, Johann Thurn, Gerhard Stock Platform Membrane Dynamics 10:00 am - 11:30 am Chair Petra Schwille, Max Planck Institute of Biochemistry, Germany No Abstract 10:00 am WHEN SIMPLE BECOMES COMPLEX - HIDDEN FUNCTIONS OF MEM- BRANE PROTEINS. Petra Schwille 485-Plat 10:30 am MEASURING MEMBRANE DYNAMICS ON THE MESOSCALE. Elizabeth G. Kelley , Paul D. Butler, Michihiro Nagao 486-Plat 10:45 am SUBCOMPARTMENTALIZATION AND PSEUDO-DIVISION OF MODEL PRO- TOCELLS. Karolina Spustova , Elif S. Koksal, Alar Ainla, Irep Gozen 487-Plat 11:00 am REAL TIME MONITORING OF TRANSIENT LIPID-LIPID INTERACTIONS ON LIVE CELL MEMBRANES USING A DNA PROBE. Yousef Bagheri , Ahsan Ausaf Ali, Mingxu You 488-Plat 11:15 am MEMBRANE BIOPHYSICS AND CHEMICAL BIOLOGY PLATFORM TO MAP THE LANDSCAPE OF VIRULENT LIPID-INDUCED EFFECTS ON HOST CELL MEMBRANE AND SIGNALING. Shobhna Kapoor , Manjari Mishra

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