Biophysical Society 65th Annual Meeting Program Guide

Platform Mechanosensation 10:00 am - 11:30 am

Platform Membrane Pumps, Transporters,

and Exchangers 10:00 am - 11:30 am

W E

Chair Pascal Martin, Institut Curie, France 489-Plat 10:00 am

Chair Jue Chen, The Rockefeller University, USA 499-Plat 10:00 am ABC TRANSPORTERS: MOLECULAR PUMPS POWERED BY ATP. Jue Chen 500-Plat 10:30 am STRUCTURE OF A VESICULAR GLUTAMATE TRANSPORTER DETERMINED BY CRYO-EM. Fei Li , Jacob Eriksen, Janet Finer-Moore, Robert H. Ed- wards, Robert M. Stroud 501-Plat 10:45 am ROLE OF INDIVIDUAL ZINC BINDING SITES IN THE CATION DIFFUSION FA- CILITATOR YIIP. Maria L. Lopez , Akiko Koide, Lorena Novoa Aponte, Shujie Fan, Oliver Beckstein, Jose M Arguello, Shohei Koide, David L. Stokes 502-Plat 11:00 am GLUTAMATE TRANSPORTERS (EAATS) CONTAIN A CONSERVED CHLORIDE CHANNEL WITH TWO HYDROPHOBIC GATES. Ichia Chen, Shashank Pant, Qianyi Wu, Rosemary J. Cater, Meghna Sobti, Robert J. Vandenberg, Alastair Stewart, Josep Font, Emad Tajkhorshid, Renae M. Ryan 503-Plat 11:15 am ION BINDING TO A MAMMALIAN SODIUM/PROTON EXCHANGER MEM- BRANE PROTEIN FROMMOLECULAR DYNAMICS SIMULATIONS. Chenou Zhang , Ricky Sexton, Iven Winkelmann, Rei Matsuoka, Pascal Meier, Denis Shutin, Laura Orellana, Michael Landreh, Carol V. Robinson, David Drew, Oliver Beckstein Platform Genetic, Cellular, Synthetic, and Systems Biology 10:00 am - 11:30 am Chair Cristina Marchetti, University of California, Santa Barbara, USA No Abstract 10:00 am PHYSICAL MODELS OF THE RHEOLOGY OF DENSE BIOLOGICAL TISSUE. M. Cristina Marchetti 504-Plat 10:30 am THE TRANSCRIPTOME DYNAMICS OF SINGLE CELLS DURING THE CELL CYCLE. Daniel Schwabe , Sara Formichetti, Jan Philipp Junker, Martin Falcke, Nikolaus Rajewsky 505-Plat 10:45 am NEGATIVE SURFACE CHARGE REGULATES BIOCHEMICAL EXCITABILITY OF CORTEX AND LIMITS PROTRUSION FORMATION. Tatsat Banerjee , Debojyoti Biswas, Dhiman S. Pal, Yuchuan Miao, Pablo A. Iglesias, Peter N. Devreotes 506-Plat 11:00 am SPATIOTEMPORAL DYNAMICS OF RAC1 SIGNALING DURING WOUND HEALING IN FORSTER RESONANCE ENERGY TRANSFER BIOSENSOR MICE. Rachel Cinco , Morgan Dragan, Enrico Gratton, Heidi Welch, Paul Timpson, Xing Dai, Michelle A. Digman 507-Plat 11:15 am HYDROPHOBICITY BASED SEQUENCE BLOBULATION APPROACH CAP- TURES FUNCTIONAL MODULARITY: DISEASE-ASSOCIATED MUTATIONS ARE ENRICHED IN HYDROPHOBIC BLOBS. Ruchi Lohia , Matthew Hansen, Grace H. Brannigan

D N

MACHANICAL FREQUENCY TUNING BY THE HAIR BUNDLE OF MECHANO- SENSORY HAIR CELLS. Pascal Martin , Mélanie Tobin, Atitheb Chaiyasitdhi 490-Plat 10:30 am TEMPORAL ANALYSIS OF T-CELL RECEPTOR-IMPOSED FORCES VIA QUAN- TITATIVE SINGLE MOLECULE FRET MEASUREMENTS. Janett Goehring , Florian Kellner, Lukas Schrangl, Rene Platzer, Hannes Stockinger, Johannes B. Huppa, Gerhard J. Schütz 491-Plat 10:45 am LIPID DROPLETS HAVE HIGH INTERFAFACIAL TENSION AND ARE SUFFI- CIENTLY RIGID TO RUPTURE THE NUCLEUS. Irena L. Ivanovska , Michael P. Tobin, Lawrence J. Dooling, Dennis E. Discher 492-Plat 11:00 am MECHANO-CHEMICAL PATTERN FORMATION IN SPHERICAL CELL SHEETS. Stephanie S. Hoehn , Moritz Mercker 493-Plat 11:15 am HETEROGENEOUSLY STRAINED TISSUE COLLAGEN RESISTS COLLAGENASE DEGRADATION WHERE STRAINS ARE HIGH. Karanvir Saini , Manu Tewari, Sangkyun Cho, Abdelaziz Jalil, Jerome Irianto, Manasvita Vashisth, Char- lotte R. Pfeifer, Jason C. Andrechak, Lawrence J. Dooling, Cory Alvey, Alex Kasznel, David Chenoweth, Kazuhiro Yamamoto, Dennis E. Discher 10 Platform Muscles II 10:00 am - 11:30 am Chair Bailong Xiao, Tsinghua University, China 494-Plat 10:00 am THE MECHANOSENSITIVE PIEZO1 CHANNEL MEDIATES HEART MECHA- NO-CHEMO TRANSDUCTION. Fan Jiang, Kun Wu, Kunlun Yin, Mingmin Zhang, Shi-Qiang Wang, Heping Cheng, Zhou Zhou, Bailong Xiao 495-Plat 10:30 am MICROTUBULES ORCHESTRATE LOCAL TRANSLATION TO ENABLE CAR- DIAC GROWTH. Keita Uchida , Emily Scarborough, Maria Vogel, Benjamin L. Prosser, Izhak Kehat 496-Plat 10:45 am DYNAMIC REGULATION OF INTRACELLULAR PH IN THE HEART. Yankun Lyu, Phung Thai, Lu Ren, Valeriy Timofeyev, Zhong Jian, Seojin Park, Ken- neth S. Ginsburg, James Overton, Julie Bossuyt, Donald M. Bers, Ebenezer N. Yamoah, Ye Chen-Izu, Nipavan Chiamvimonvat, Xiao-Dong Zhang 497-Plat 11:00 am BURST-LIKE TRANSCRIPTION OF SARCOMERIC GENES IN HYPERTROPHIC CARDIOMYOPATHY. Valentin Burkart, Julia Beck, David Aldag-Niebling, Kathrin Kowalski, Ante Radocaj, Jolanda van der Velden, Cris G. dos Re- medios, Denise Hilfiker-Kleiner, Theresia Kraft, Judith Montag 498-Plat 11:15 am HIPSC DERIVED CARDIOMYOCYTES OVEREXPRESSING DEOXY ATP TO RESTORE CARDIAC FUNCTION IN MYOCARDIAL INFARCTION. Ketaki N. Mhatre , Farid Moussavi-Harami,, Julie Mathieu, Charles Murry, Michael Regnier

E S

D A Y

41