Biophysical Society 65th Annual Meeting Program Guide

Protein Structure and Conformation II (Boards B1 - B34) 550-Pos B oard B1 HD-ANM A COMPUTATIONALLY EFFICIENT, HIGHLY CUSTOMIZABLE AND COMPREHENSIVE ELASTIC NETWORK MODEL. Pranav M. Khade , Domenico Scaramozzino, Ambuj Kumar, Robert L. Jernigan 551-Pos B oard B2 DEVELOPING EFFICIENT TRANSFER FREE ENERGY CALCULATION METH- ODS FOR HYDROPHOBICITY PREDICTIONS. Adithya Polasa , Seyed Hamid Tabari, Mahmoud Moradi 552-Pos B oard B3 INFERRING DELETERIOUS MUTATIONAL REGION IN CANCER FROM PROTEIN STRUCTURE. Boshen Wang , Xue Lei, Wei Tian, Yanyuan Tseng, B oard B4 GENERATING PROTEIN ENSEMBLES BY APPLYING FORCES TO AN IM- PROVED ELASTIC NETWORK MODEL. Ambuj Kumar , Pranav M. Khade, Domenico Scaramozzino, Karin Dorman, Robert L. Jernigan 554-Pos B oard B5 IN SILICO GENERATION OF HOLO-LIKE CONFORMATIONS OF VERY FLEX- IBLE ALLOSTERIC PROTEINS BEARING MULTIPLE BINDING SITES. Andrea Basciu , Attilio V. Vargiu, Giuliano Malloci, Paolo Ruggerone, Alexandre M. Bonvin 555-Pos B oard B6 PREDICTION OF A PROTEIN’S FREE ENERGY SURFACE AND VALIDATION WITH HD EXCHANGE. Xiangda Peng , Nabil F. Faruk, Michael Baxa, Scott Houliston, Karl F. Freed, Cheryl Arrowsmith, Gabriel J. Rocklin, Tobin R. B oard B7 COMPUTATIONAL INSIGHTS INTO THE EFFECT OF GASTRIC PH ON THE STABILITY OF APO-LACTOFERRIN AND ITS INTERACTIONS WITH Α-LACTALBUMIN AND Β-LACTOGLOBULIN. Kevion Darmawan , Tom C. Karagiannis, Jeff Hughes, Darryl Small, Andrew Hung 557-Pos B oard B8 A COMBINATORIAL APPROACH TO EXAMINE PROTEIN-PROTEIN INTER- ACTION BASED SUBSTRATE SELECTIVITY IN E. COLI FATTY ACID BIOSYN- THESIS. Thomas Bartholow 558-Pos B oard B9 STRUCTURAL STUDIES OF DESIGNED CHIMERIC PROTEINS AND PRE- DICTIONS OF MUTATIONAL EFFECTS. Victor Zhao , João V. Rodrigues, Eugene I. Shakhnovich 559-Pos B oard B10 HIGH-THROUGHPUT DISULFIDE SCANNING OF IN VIVO PROTEIN CON - FORMATIONS. Eugene Serebryany , Eugene Shakhnovich 560-Pos B oard B11 EMPLOYING AN UNNATURAL AMINO ACID TO EXAMINE LOCAL ENVI- RONMENTS IN MULTIPLE PROTEIN SYSTEMS. Christine M. Phillips-Piro , Scott H. Brewer 561-Pos B oard B12 LEVERAGING HDX-MS SOLUTION DATA AND HDX MODELING TO REFINE MOLECULAR DYNAMICS ENSEMBLES AND GAIN AN ATOMISTIC UNDERSTANDING OF BIOPHYSICAL PHENOMENA. Kyle C. Kihn , Daniel J. Deredge, Patrick L. Wintrode Jie Liang 553-Pos Sosnick 556-Pos

562-Pos B oard B13 MAPPING THE EPITOPE INTERACTIONS OF TRASTUZUMAB VIA PLASMA INDUCED MODIFICATION OF BIOMOLECULES (PLIMB). Daniel Benjamin , Faraz A. Choudhury, Benjamin Minkoff, Claire Bramwell, St John Skilton, Michael R. Sussman 563-Pos B oard B14 FLUORESCENCE ANISOTROPY EEMS: ADDING A NEW DIMENSION TO THE STUDY OF PROTEIN LOCAL ENVIRONMENT. Karen E. Gall , Alex Siemiarczuk 564-Pos B oard B15 EFFECTS OF CRYO-EM FREEZING ON STRUCTURAL ENSEMBLES. Helmut Grubmuller , Lars V. Bock 565-Pos B oard B16 ACROSS THE E. COLI PROTEOME IT IS COMMON FOR PROTEINS TO BECOME KINETICALLY TRAPPED IN SOLUBLE, NEAR-NATIVE, NON- FUNCTIONAL CONFORMATIONS THAT BYPASS THE PROTEOSTASIS NETWORK. Daniel A. Nissley , Fabio Trovato, Ian M. Sitarik, Yang Jiang, Karthik Narayan, Edward P. O’Brien 566-Pos B oard B17 THE TRANSITION PATHWAY BETWEEN THE CLOSED AND OPEN STATES OF INSULIN DEGRADING ENZYME SHOWS TWO DISTINCT MOTIONS: ROTATION AROUND A HINGE AND GRINDING BETWEEN TWO DO- MAINS. David Tang , Wei-Jen Tang, Jordan Mancl, Esmael J. Haddadian 567-Pos B oard B18 PRESSURE ACCELERATES THE CIRCADIAN CLOCK OF CYANOBACTE- RIA. Ryo Kitahara , Keita Mitsuhashi, Soichiro Kitazawa, Kazuki Terauchi 568-Pos B oard B19 PRESSURE-TEMPERATURE LANDSCAPE OF THE UNFOLDED STATE OF CLT9-I98A PROTEIN. Balasubramanian Harish , Richard Gillilan, Daniel P. Raleigh, Catherine A. Royer 569-Pos B oard B20 PROBING PRESSURE EFFECTS ON CORE PACKING OF A REPEAT PROTEIN USING 13C-1H NMR. Siwen Zhang , Scott McCallum, Catherine A. Royer 570-Pos B oard B21 ULTRA-HIGH RESOLUTION AND CHARGE-DENSITY STUDIES ON THE TYPE-I COPPER PROTEIN AMICYANIN, FROM PARACOCCUS DENITRIFI - CANS . Narayanasami Sukumar , Igor Kurinov, Malcolm S. Capel, James Withrow, Sahana L. Sukumar, Victor L. Davidson 571-Pos B oard B22 THE STRUCTURAL ENVIRONMENT AROUND THE HEME-BINDING SITE IN CYCLOOXYGENASE AND ITS IMPLICATION. Inseok Song 572-Pos B oard B23 STRUCTURAL AND FUNCTIONAL INSIGHTS OF AN UNPRECEDENTED MULTIHEME CYTOCHROME FROM GEOBACTER SULFURREDU - CENS . Tomás M. Fernandes , Leonor Morgado, Filipe Folgosa, Miguel Teixeira, Carlos A. Salgueiro 573-Pos B oard B24 TEMPERATURE DEPENDENCE OF INFRARED LIGHT TIME COURSE UNDER OXYGENATION AND DEOXYGENATION OF THE BLOOD IN VITRO. Marina Kirichenko , George Rybalchenko, Sergey Gavrilkin, Alexey Kirichenko 574-Pos B oard B25 Withdrawn 575-Pos B oard B26 STRUCTURAL BASIS FOR P450-MEDIATED OXYSTEROL METABOLISM BY MYCOBACTERIUM TUBERCULOSIS . Sergey S. Bukhdruker , Tatsiana Varaksa, Irina Grabovec, Egor Marin, Anton Kavaleuski, Polina Shabunya, Anastasiia Gusach, Kirill Kovalev, Ivan Kapranov, Alexey Mishin, Andrei Gilep, Natallia Strushkevich, Valentin Borshchevskiy

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