Biophysical Society 65th Annual Meeting Program Guide

603-Pos B oard B54 CHARACTERIZATION OF A NEW HETERO-FRET BIOSENSOR TO MEASURE ENVIRONMENTAL IONIC STRENGTH. Chioma Nwachuku, Emmanuel Tetteh-Jada, Malachy Brink , Scarlet Hoffman, Boqun Liu, Arnold J. Boersma, Ahmed A. Heikal, Erin D. Sheets 604-Pos B oard B55 ROLE OF LIGAND-BINDING AND NON-ACTIVE SITE RESIDUES IN THE DYNAMICS, CONFORMATIONAL INTEGRITY, AND CATALYSIS OF THE DISORDERED ENZYME MONOMERIC CHORISMATE MUTASE. Shrutidhara Biswas , Rajaram Swaminathan 605-Pos B oard B56 PROBING ALLOSTERY IN OLIGOMERIC M 2 RECEPTORS USING SMFRET. Dennis D. Fernandes , Aimen Malik, Claudiu C. Gradinaru 606-Pos B oard B57 SINGLE-MOLECULE INSIGHTS INTO ALLOSTERIC REGULATION OF THE NUCLEAR RECEPTOR PROTEIN RXRΑ. Jakub Jungwirth , Sayan Mondal, Mahran Shehade, Demian Liebermann, Dorit Levy, Inbal Riven, Gilad Haran 607-Pos B oard B58 RESURRECTED ANCESTRAL TIM-BARREL GLYCOSIDASE DISPLAYS HEME BINDING AND ALLOSTERIC MODULATION. Luis I. Gutierrez-Rus , Gloria Gamiz-Arco, Valeria A. Risso, Beatriz Ibarra-Molero, Yosuke Hoshino, Dušan Petrović, Jose Justicia, Juan Manuel Cuerva, Adrian Romero-Rivera, Burckhard Seelig, Jose A. Gavira, Shina C.L. Kamerlin, Eric A. Gaucher, Jose M. Sanchez-Ruiz 608-Pos B oard B59 ANISOTROPIC TERAHERTZ MICROSCOPY OF LYSOZYME IN DIFFERENT CRYSTAL LATTICE SYSTEMS. Jeffrey A. McKinney , Deepu K. George, Yant- ing Deng, Andrea G. Markelz 609-Pos B oard B60 UTILIZING PH-DRIVEN TIME-RESOLVED CRYSTALLOGRAPHY TO ELUCIDATE THE HYDRIDE TRANSFER MECHANISM IN BACTERIAL HMG-COA REDUC- TASE. Vatsal Purohit , Calvin Steussy, Tim Schmidt, Chandra J. Critchelow, Tony Rosales, Paul Helquist, Olaf Wiest, Cynthia V. Stauffacher 610-Pos B oard B61 MECHANISTIC BASIS FOR UBIQUITIN MODULATION OF A PROTEIN EN- ERGY LANDSCAPE. Emma Carroll , Naomi R. Latorraca, Johanna Lindner, Jeff Pelton, Brendan Maguire, Susan Marqusee 611-Pos B oard B62 MAPPING BINDING EPITOPES AND ALLOSTERIC EFFECTS IN STAPH EN- TEROTOXINS. Clint Vorauer , Miklos Guttman 612-Pos B oard B63 STRUCTURAL DYNAMICS OF THE HETERODIMERIZATION BETWEEN THE DNA-BINDING DOMAINS FROM HUMAN FOXP1 AND FOP2 TRANSCRIP- TION FACTORS. Exequiel Medina, Ricardo Coñuecar, Cesar A. Ramirez- Sarmiento, Hugo Sanabria , Jorge Babul 613-Pos B oard B64 HDX-MS GUIDED ENSEMBLE REWEIGHTING APPROACH CHARACTERIZES A LARGE CONFORMATIONAL REARRANGEMENT IN THE CYTOPLASMIC HEME BINDING PROTEIN PHUS. Kyle C. Kihn, Tyree Wilson, Richard T. Bradshaw, Patrick L. Wintrode, Lucy R. Forrest, Angela Wilks, Daniel J. B oard B65 THERMAL TRANSFER FROM THE SURFACE LOOP TO THE IRON ACTIVE SITE OF SOYBEAN LIPOXYGENASE. Jan Paulo Zaragoza Deredge 614-Pos

615-Pos B oard B66 ALLOSTERIC REGULATION OF THE ACTIVITY OF BY-KINASES, A UNIQUE FAMILY OF BACTERIAL PROTEIN TYROSINE KINASES. Fatlum Hajredini , Andrea Piserchio, Rinat Abzalimov, Ranajeet Ghose 616-Pos B oard B67 MAPPING BINDING INTERFACES AND ALLOSTERIC CHANGES IN THE SARS- COV-2 SPIKE PROTEIN USING HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY. Shawn M. Costello , Helen T. Hobbs, Sophie R. Shoe- maker, Abigail E. Powell, Shion A. Lim, James A. Wells, Peter S. Kim, John E. Pak, Susan Marqusee 617-Pos B oard B68 CONFORMATIONAL DYNAMICS IN NF-ĸB TRANSCRIPTIONAL REGULA- TION. Wei Chen , Elizabeth A. Komives 618-Pos B oard B69 INSIGHT INTO CULLIN RING LIGASE AND SUBSTRATE BINDING. Philip R. Belzeski , Ryan Lumpkin, Christopher Condon, Elizabeth A. Komives 619-Pos B oard B70 DISULFIDE REDUCTION ALLOSTERICALLY DESTABILIZES THE Β-LADDER SUB-DOMAIN ASSEMBLY WITHIN THE NS1 DIMER OF ZIKV. Priti Roy , Subhajit Roy, Neelanjana Sengupta 620-Pos B oard B71 SOLVATION DRIVES G-PROTEIN-COUPLED RECEPTOR ACTIVATION. Nipuna Weerasinghe , Steven D.E. Fried, Andrey V. Struts, Suchithranga M.D.C. Perera, Michael F. Brown 621-Pos B oard B72 CALCIUM DISSOCIATION OF HCM CAUSATIVE R21C TROPONIN I MUTA- TION. Romi Castillo , Anthony Baldo, MatthewM. Klass, Melissa L. Lynn, Steven D. Schwartz, Jil C. Tardiff 622-Pos B oard B73 ALLOSTERIC REGULATION IN CRISPR/CAS1-CAS2 ACQUISITION OF PROTO- SPACER DNA IN CLOSE ASSOCIATION WITH CAS2. Chunhong Long , Liqiang Dai, Chao E, Jin Yu 623-Pos B oard B74 SODIUM BINDING IN CYSTEINYL LEUKOTRIENE G PROTEIN-COUPLED RECEPTORS. Viktoriia Shaulskaia , Aleksandra Luginina, Polina Khorn, Anastasiia Gusach, Olga Sukhacheva, Ekaterina Smirnova, Valentin Borsh- chevskiy, Alexey Mishin, Vadim Cherezov 624-Pos B oard B75 PROTEOME-SCALE ANALYSIS OF VERTEBRATE PROTEIN THERMOADAP- TATION MODULATED BY DYNAMIC ALLOSTERY AND PROTEIN SOLVA- TION. Zhenlu Li , Matthias Buck Membrane Protein Dynamics I (Boards B76 - B93) 625-Pos B oard B76 MOLECULAR SIMULATIONS REVEAL THE DYNAMICS OF THE T-CELL RECEP- TOR IN A T-CELL MODEL MEMBRANE. Dheeraj Prakaash , Oreste Acuto, Graham Cook, Antreas Kalli 626-Pos B oard B77 MOLECULAR DYNAMICS INVESTIGATION OF THE INFLUENZA HEMAGGLU- TININ CONFORMATIONAL CHANGES. Shadi Asadian Ghahfarokhi , Vivek Govind Kumar, Mahmoud Moradi 627-Pos B oard B78 A COMPUTATIONAL STUDY OF THE DYNAMICS OF CADHERIN-CATENIN COMPLEX REGULATED BY ACTIN CYTOSKELETON. Qilin Yu , Taeyoon Kim, Vijay Rajagopal

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