Biophysical Society 65th Annual Meeting Program Guide

667-Pos B oard B118 TIN2 IS AN ARCHITECTURE PROTEIN THAT FACILITATES TRF2-MEDIATED HIGHER-ORDER DNA AND RNA STRUCTURES AT TELOMERES. Parminder Kaur , Hai Pan, Hong Wang, Robert Riehn 668-Pos B oard B119 TIN2 FACILITATES TRF1-MEDIATED TRANS- AND CIS-INTERACTIONS ON PHYSIOLOGICALLY RELEVANT LONG TELOMERIC DNA. Hai Pan , Parminder Kaur, Ryan Barnes, Qingyu Tang, Keith R. Weninger, Robert Riehn, Susan Smith, Patricia L. Opresko, Hong Wang 669-Pos B oard B120 A STRUCTURALLY CONSERVED HUMAN AND TETRAHYMENA TELOM- ERASE CATALYTIC CORE. Yaqiang Wang , Marcus Gallagher-Jones, Lukas Sušac, He Song, Juli Feigon 670-Pos B oard B121 AN AUTOINHIBITORY ROLE FOR THE GRF ZINC FINGER DOMAIN OF DNA GLYCOSYLASE NEIL3. Alyssa A. Rodriguez 671-Pos B oard B122 SEQUENCE DEPENDENT BARRIERS TO NUCLEOSOME UNWRAP- PING. William Hu, Phu Tang, Anjela Manandhar, Kaushik Chakraborty, Sharon M. Loverde 672-Pos B oard B123 DNA DYNAMICS DURING SWR1-CATALYZED H2A.Z HISTONE EX- CHANGE. Xinyu A. Feng , Matthew F. Poyton, Anand Ranjan, Myung Hyun Jo, Jasmin Zarb, Robert K. Louder, Giho Park, Qin Lei, Sheng Liu, Carl Wu, Taekjip Ha 673-Pos B oard B124 ATOMIC-SCALE MOLECULAR DIFFUSION OF A TRANSCRIPTION FACTOR DOMAIN PROTEIN ALONG DNA. Liqiang Dai, Yongping Xu, Zhengwei Du, Xiaodong Su, Jin Yu 674-Pos B oard B125 OCT4 PIONEERS GENOMIC NUCLEOSOMES IN MOTION. Jan Huertas, Caitlin MacCarthy, Hans Robert Schoeler, Vlad Cojocaru 675-Pos B oard B126 A MODEL OF BZIP PROTEIN/DNA RECOGNITION USING KNOB-SOCKET ANALYSIS. Aaron Tran , Hyun Joo, Jerry Tsai 676-Pos B oard B127 INCHWORM STEPPING OF MYC-MAX HETERODIMER PROTEIN DIFFU- SION ALONG DNA. Liqiang Dai , Jin Yu 677-Pos B oard B128 A NOVEL G1/S TRANSCRIPTION FACTOR FEEDBACK LOOP IN THE START TRANSITION IN BUDDING YEAST REVEALED BY SCANNING NUMBER AND BRIGHTNESS. Pooja Goswami , Savanna Dorsey, Carleton Coffin, Ghada Ghazal, Yogitha Thattikota, Jing Cheng, Sylvain Tollis, Mike Tyers, Catherine A. Royer 678-Pos B oard B129 IN SILICO INVESTIGATIONS ON SWITCHING PROMOTOR RECOGNITION OF PHAGE RNA POLYMERASE VARIANTS FOLLOWING PATH ALONG LAB DIRECTED EVOLUTION. Chao E , Liqiang Dai, Jin Yu 679-Pos B oard B130 LOW TEMPERATURE INDUCED CONFINED EFFECT FOR AEROLYSIN NANOPORE SENSING. Bo-Qiang He , Yi-Lun Ying, Yi-Tao Long

654-Pos B oard B105 MYC AMPLIFIES GENE EXPRESSION THROUGH GLOBAL CHANGES IN TRAN- SCRIPTION FACTOR DYNAMICS. Daniel R. Larson 655-Pos B oard B106 INFLUENCE OF T 3 ON ACTIVE TRANSCRIPTION OF MYBPC3 AND TNNI3 . Kathrin Kowalski , Jan N. Riesselmann, Natalie Weber, Birgit Piep, Annika Franke, Ulrich Martin, Robert Zweigerdt, Theresia Kraft 656-Pos B oard B107 CHARACTERIZATION OF THE FUNCTIONAL RELEVANCE OF INTRANUCLEAR TRANSCRIPTION FACTOR AGGREGATES IN LIVING FLY EMBRYOS. Rahul Munshi , Michal Levo, Eric Wieschaus, Thomas Gregor 657-Pos B oard B108 DETERMINING LONG NONCODING RNA MECHANISMS IN STEM CELLS USING AUTOMATED IMAGE ANALYSIS AND SINGLE MOLECULE RNA-FLUO- RESCENT IN SITU HYBRIDIZATION. Benjamin Kesler , Gregor Neuert 658-Pos B oard B109 COMPARISON OF BIAS AND RESOLVABILITY IN SINGLE-CELL AND SINGLE- TRANSCRIPT METHODS. Jayan Rammohan , Steven P. Lund, Nina Alperov- ich, Vanya Paralanov, Elizabeth A. Strychalski, David Ross 659-Pos B oard B110 INTRODUCING CHEMICALLY MODIFIED NUCLEOTIDES TO IMPROVE MRNA- BASED THERAPEUTICS. Teena Bajaj Protein-Nucleic Acid Interactions II (Boards B111 - B130) 660-Pos B oard B111 RESIDUE-LEVEL FUNCTIONAL COUPLINGS AND THEIR EFFECT ON RNA REMODELLING BY THE ZIKA VIRUS NS3 HELICASE. Sunaina Banerjee, Divya K, Rahul Roy 661-Pos B oard B112 CHARACTERIZING THE IMPACT OF CANCER MUTATIONS IN DNA BASE EDIT- ING ENZYMES. Gerardo A. Cisneros 662-Pos B oard B113 COORDINATED MOTION OF DIMERIC INTERFACES IN EUKARYOTIC TYPE IIA TOPOISOMERASES. Nilusha L. Kariyawasam , John L. Nitiss, Jeffery M. Wereszczynski 663-Pos B oard B114 RAPID SEARCH AND REPAIR STRATEGIES OF DNA DAMAGE REPAIR PRO- TEINS ON CHROMATIN. Genesis M. Ferrer , Shankar Lalitha Sridhar, Jeffrey Dunagin, Loren Hough 664-Pos B oard B115 HUMAN MITOCHONDRIAL HELICASE TWINKLE CATALYZES TOEHOLD MEDI- ATED DNA STRAND DISPLACEMENT. Anupam Singh , Gayatri Patel, Laura C. Johnson, Smita S. Patel 665-Pos B oard B116 CRITICAL ROLE OF CONSERVED HISTIDINE RESIDUES IN GENOME EDITING AND RECOMBINATION. Lukasz Nierzwicki , Lorenzo Casalino, Martin Jinek, Giulia Palermo 666-Pos B oard B117 MASSIVELY PARALLEL KINETIC PROFILING OF NATURAL AND ENGINEERED CRISPR NUCLEASES. Stephen K. Jones , John A. Hawkins, Nicole V. Johnson, Cheulhee Jung, Kuang Hu, James R. Rybarski, Janice S. Chen, Jennifer A. Doudna, William H. Press, Ilya J. Finkelstein

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