Biophysical Society 65th Annual Meeting Program Guide

Protein-Small Molecule Interactions II (Boards B28 - B49) 978-Pos B oard B28 INVESTIGATION OF MOLECULAR COUNTERMEASURES TO MODULATE THE POPULATIONS AND TOXICITY OF AΒ42 OLIGOMERS. Aidan K. Wright , Ryan P. Kreiser, Lam T. Nguyen, Jared E. Hollows, Ryan Limbocker 979-Pos B oard B29 CONTROL OVER PROTEIN MULTIMERIZATION INDUCED BY WATER-SOLU- BLE PORPHYRINS. Tyler Brittain , Oleksandr Kokhan 980-Pos B oard B30 DETERMINING VITRONECTIN’S ROLE IN FORMING THE HALLMARK OF AGE-RELATED MACULAR DEGENERATION. Kyungsoo Shin , L. Miya Fujimoto, James E. Kent, Alexander Aleshin, Ye Tian, Andrey A. Bobkov, Wonpil Im, Francesca M. Marassi 981-Pos B oard B31 PREDICTING ARRHYTHMOGENICITY: STRUCTURAL MODELING OF SAFE AND UNSAFE HERG BLOCKERS. Aiyana M. Emigh , Kevin R. DeMarco, Ka- zuharu Furutani, Jon T. Sack, Colleen E. Clancy, Igor V. Vorobyov, Vladimir Yarov-Yarovoy 982-Pos B oard B32 A NOVEL MODEL OF THE DIMERIC HUMAN HV1 CHANNEL REVEALS A PUTATIVE ATP BINDING SITE. Manuel A. Llanos , Pedro Martín, Nicolas Enrique, Juan Ignacio Felice, Agustín Aguaje, Luciana Gavernet, Veronica Milesi, Clara Ventura 983-Pos B oard B33 MOLECULAR MECHANISM OF THE POTENT BENZOPYRAN-G1 BLOCKER OF HETEROMERIC G-PROTEIN GATED POTASSIUM CHANNELS. Meng Cui , Yaser Alhamshari, Lucas Cantwell, Said EI-Haou, Giasemi C. Eptaminitaki, Mengmeng Chang, Obada Abou-Assali, Haozhou Tan, Keman Xu, Meghan Masotti, Leigh D. Plant, Ganesh Thakur, Sami Noujaim, James T. Milnes, Diomedes E. Logothetis 984-Pos B oard B34 THE NOVEL SMALL MOLECULE 3HI2ONE-G4 SELECTIVELY ACTIVATES HOMOMERIC GIRK4 CHANNELS. Meng Cui , Keman Xu, Michelle Ban, Giasemi C. Eptaminitaki, Diomedes E. Logothetis 985-Pos B oard B35 MONITORING LIGAND BINDING TO PURIFIED HCN4 CHANNEL PRO- TEINS. Andrea Saponaro , Atiyeh Sadat Sharifzadeh, Anna Moroni 986-Pos B oard B36 BEYOND VOLUME EXCLUSION-NANOPORE-BASED PROTEIN SEQUENC- ING. Ming-Zhu Huo , Meng-Yin Li, Yi-Lun Ying, Yi-Tao Long 987-Pos B oard B37 PREDICTION AND ANALYSIS OF MULTIPLE SITES AND INHIBITORS OF SARS-COV-2 PROTEINS. Suhasini M. Iyengar , Kelton Barnsley, Hoang Yen Vu, Ryan Dilworth, Jana Sefcikova, Penny Beuning, Mary Jo Ondrechen 988-Pos B oard B38 THE DESIGN OF A DESTABILIZER PEPTIDE TO DISRUPT SARS-COV-2 FU- SION WITH ITS TARGETED CELL MEMBRANE. Motamed Qadan 989-Pos B oard B39 MECHANISM AND PATHWAYS OF INHIBITOR BINDING TO THE HUMAN ACE2 RECEPTOR FOR SARS-COV1/2. Apurba Bhattarai , Shristi Pawnikar, Yinglong Miao 990-Pos B oard B40 IDENTIFICATION OF FDA APPROVED ANTIVIRAL DRUGS FOR COVID-19 TREATMENT USING UNBIASED VIRTUAL SCREENING. Rory Greer , Yuwei Song, Michael J. Patton, MatthewMight, Kevin Harrod, Chad M. Petit, Yuhua Song

991-Pos B oard B41 INHIBITOR BINDING INFLUENCES THE PROTONATION STATE OF HISTI- DINES IN SARS-COV-2 MAIN PROTEASE. Anna Pavlova , Diane L. Lynch, Micholas Dean Smith, Jeremy D. Smith, James C. Gumbart 992-Pos B oard B42 VITAMIN D AND ITS DERIVATIVES AS PROMISING DRUGS AGAINST COV- ID-19 - A COMPUTATIONAL STUDY. Yuwei Song , Shariq Qayyum, Radomir Slominski, Chander Raman, Andrzej Slominski, Yuhua Song 993-Pos B oard B43 INVESTIGATING BACTERIAL MALONYL-COA:ACYL TRANSFERASE AS A PO- TENTIAL SECONDARY TARGET OF 3-HYDROXY-3-METHYL-GLUTARYL-COA REDUCTASE INHIBITORS. Gillian M. Barth , Calvin Steussy, Tim Schmidt, Cynthia V. Stauffacher 994-Pos B oard B44 DISCOVERY OF SMALL MOLECULE INHIBITORS AND ACTIVATORS OF DEATH RECEPTOR 5 SIGNALING USING HIGH THROUGHPUT SCREEN- ING. Malaney Young , Nagamani Vunnam, Chih Hung Lo, Jonathan N. Sachs 995-Pos B oard B45 INVESTIGATING THE BINDING INTERACTION BETWEEN Β-LACTOGLOBULIN AND VITAMIN B12: A SPECTROSCOPIC AND COMPU- TATIONAL APPROACH. Janmejaya Rout , Bikash C. Swain, Suchismita Sub- adini, Sakshi Sakshi, Padmaja P. Mishra, Harekrushna Sahoo, Umakanta B oard B46 MAPPING THE INTERACTIONS OF PKNB WITH SMALL MOLECULE INHIBI- TORS USING PLASMA INDUCED MODIFICATIONS OF BIOMOLECULES (PLIMB). Faraz A. Choudhury , Nathan Wlodarchak, Benjamin Minkoff, Daniel Benjamin, Claire Bramwell, Rob Striker, Michael R. Sussman 997-Pos B oard B47 PROTEIN-LIGAND RECOGNITION ACCORDING TO LOCK-AND-KEY PRINCI- PLE. Daumantas Matulis , Vaida Paketuryte, Denis Baronas, Asta Zubrien, Joana Gylyte, Virginija Dudutiene 998-Pos B oard B48 YEAST HSP110 HAS A UNIQUE SUBSTRATE BINDING SITE ESSENTIAL FOR CHAPERONE ACTIVITY. Ying Wang , Ying Yang, Hongtao Li, Jiayue Su, Lei Zhou, Qingdai Liu, Qinglian Liu 999-Pos B oard B49 MECHANISM OF HIV-1 NC PROTEIN-INDUCED CONDENSATION OF DOUBLE STRANDED DNA AS A MODEL FOR DNA COMPACTION DURING REVERSE TRANSCRIPTION. Helena Gien , Michael Morse, Jonathan Kitz- row, Ioulia F. Rouzina, Karin Musier-Forsyth, Mark C. Williams Protein Assemblies II (Boards B50 - B65) 1000-Pos B oard B50 PROTEIN SUPERSATURATION DRIVES INNATE IMMUNITY SIGNALING. Ale- jandro Rodriguez Gama, Shriram Venkatesan, Tejbir Kandola, Tayla Miller, Randal Halfmann 1001-Pos B oard B51 CONTRASTING EFFECTS OF SOFT AND HARD CROWDERS ON AMYLOID AGGREGATION. Myeongsang Lee 1002-Pos B oard B52 STRUCTURE AND DYNAMICS OF THE E. COLI CHEMOTAXIS CORE SIGNAL- LING COMPLEX. Keith Cassidy 1003-Pos B oard B53 DYNAMICS OF BIOFILMMATRIX ASSEMBLY IN THE MODEL ORGANISM PSEUDOMONAS AERUGINOSA . Courtney Reichhardt , Michael Mat- wichuk, Holly M. Jacobs, Matthew R. Parsek Tripathy 996-Pos

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