Biophysical Society 67th Annual Meeting Program Guide

Intracellular Calcium Channels and Calcium Sparks and Waves (Boards B285 - B294)

1144-pos Board B273 DYNAMIC CALCIUM-CALMODULIN-DEPENDENT STABILIZATION OF LEAKY RYR2 IN LIVE CARDIAC MYOCYTES. Victor Alencar 1145-pos Board B274 DANTROLENE IMPROVES DIASTOLIC PROPERTY OF LEFT VENTRICLE IN MINERALCORTICOID-INDUCED HYPERTENSIVE RATS. Junya Nawata , Takeshi Yamamoto, Tomoyuki Uchida, Takeshi Suetomi, Hitoshi Uchi noumi, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yano 1146-pos Board B275 DEFECTIVE CALMODULIN BINDING AFFINITY TO RYANODINE RECEP TOR DRIVES HEART FAILURE WITH PRESERVED EJECTION FRACTION PROGRESSION. Tomoyuki Uchida , Tetsuro Oda, Junya Nawata, Takeshi Suetomi, Hitoshi Uchinoumi, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano 1147-pos Board B276 POST-TRANSLATIONAL MODIFICATION-DEPENDENT REGULATION OF CAMKII-DELTA CONFORMATION IN LIVE CARDIAC MYOCYTES. Christo pher Y. Ko , Leann T. Le, Daria Smoliarchuk, Sonya Baidar, Jakub Tomek, Chidera C. Alim, Juliana Mira Hernandez, Jody L. Martin, Donald M. Bers 1148-pos Board B277 DYNAMIC COMMUNICATION BETWEEN TRPC3 AND IP3R SHAPE CA 2+ SIGNALING SIGNATURES. Klaus Groschner , Hazel Erkan-Candag, Sanja Curcic 1149-pos Board B278 SPATIO-SPECIFIC CAMKII ACTIVATION IN CARDIOMYOCYTES FROM HY PERTENSIVE DAHL SALT-SENSITIVE RATS. Julia Voglhuber , Ingrid Matzer, Natasa Djalinac, Mara Kiessling, Viktoria Trummer-Herbst, Michael Holzer, Andreas Zirlik, Senka Holzer 1150-pos Board B279 SYNCHRONIZATION OF PACEMAKER CELL FIRING UNDERLIES AUTONOM IC MODULATION OF BEATING INTERVALS AND THEIR VARIABILITY IN A NUMERICAL MODEL OF HETEROGENEOUS SA NODE TISSUE. Alexander V. Maltsev , Andy Lu, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev 1151-pos Board B280 SUPER-RESOLVED SIM IMAGING REVEALED HIERARCHICAL ORGANIZA TION OF THE RYANODINE RECEPTOR NETWORK IN 3 DIMENSIONS IN RABBIT SINOATRIAL NODE CELLS. Valeria Ventura Subirachs , Alexander V. Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev 1152-pos Board B281 MOLECULAR MECHANISMS OF CARDIAC COMPLICATIONS ASSOCIATED WITH COVID-19. Steven R. Reiken , Haikel Dridi, Leah Sittenfeld, Yang Liu, Andrew R. Marks 1153-pos Board B282 HEART FAILURE (HF) ALTERS DISTRIBUTION AND SPATIAL ASSOCIA TION PROFILES OF CALMODULIN (CAM) AND CAM TARGET PROTEIN MRNAS. Vladimir Bogdanov , Andrew Soltisz, Casey Beard, Benjamin Hernandez Orengo, Galina Sakuta, Rengasayee Veeraraghavan, Jonathan Davis, Sandor Gyorke 1154-pos Board B283 AN INTEGRATE-AND-FIRE APPROACH TO CA 2+ SIGNALING - THE NOISE OF PUFFS. Lukas Ramlow , Martin Falcke, Benjamin Lindner 1155-pos Board B284 PHYSIOLOGICAL SIGNIFICANCE OF TISSUE-SPECIFIC MICU REGULATION OF MITOCHONDRIAL CALCIUM UPTAKE. Madison Rodriguez , Chen-Wei Tsai, Ming-Feng Tsai

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1156-pos Board B285 CAVEOLAE-RESTRICTED MECHANO-CHEMICAL SIGNAL TRANSDUCTION IN MOUSE ATRIAL MYOCYTES. Roman Y. Medvedev , Daniel G.P. Turner, Julia Gorelik, Francisco Alvarado, Vladimir E. Bondarenko, Alexey V. Glukhov 1157-pos Board B286 INTERSUBUNIT CROSS-LINKING IS THE KEY MECHANISM OF CARDIAC RYANODINE RECEPTOR DYSFUNCTION DURING OXIDATIVE STRESS: THE ROLE OF CYSTEINES 1078 AND 2991. Roman Nikolaienko , Elisa Bovo, Ryan Gracia, Thomas Jamrozik, Daniel Kahn, Aleksey V. Zima 1158-pos Board B287 DETECTION AND CLASSIFICATION OF CA²⁺ RELEASE EVENTS IN CARDIO MYOCYTES USING 3D-UNET NEURAL NETWORK. Prisca R. Dotti , Miguel Fernandez-Tenorio, Radoslav Janicek, Pablo Márquez-Neila, Marcel Wul lschleger, Raphael Sznitman, Marcel Egger 1159-pos Board B288 ARRHYTHMIA SEVERITY IN MOUSE MODELS HARBORING RYR2 MUTA TIONS WITH VARIED EXTENT OF CHANNEL ACTIVITY. Nagomi Kurebayashi , Masami Kodama, Takashi Murayama, Masami Sugihara, Masato Konishi, Aya Miura, Hajime Nishio, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Takashi Sakurai 1160-pos Board B289 ROLE OF NEURONAL RYANODINE RECEPTOR TYPE 2 IN CARDIOGENIC DEMENTIA. Haikel Dridi , Yang Liu, Xiaoping Liu, Steven R. Reiken, Marco Miotto, Leah Sittenfeld, Qi Yuan, Rajesh Soni, Alain Lacampagne, Andrew Board B290 CNS-FOCUSED HIGH THROUGHPUT SCREENING FOR RYR-TARGETED THERAPEUTICS. Levy M. Treinen , Johnathan C. Solberg, Robyn T. Reb beck, Marzenna Brinkmann, Kaja Berg, Jake A. Schwarz, Andrew R. Thompson, Courtney C. Aldrich, David D. Thomas, Jennifer J. Thomas, Razvan L. Cornea 1162-pos Board B291 MODULATING MITOCHONDRIAL PHOSPHATE TRANSPORT SHAPES IN TRACELLULAR CA SIGNALING TO IMPACT ARRHYTHMOGENESIS. Arpita Deb , Bjorn C. Knollmann, Bin Liu 1163-pos Board B292 THE ROLE OF MITOCHONDRIAL-ASSOCIATED-MEMBRANES IN CA DEPENDENT ARRHYTHMIAS. Arpita Deb, Oluwabori Adekanye, Bjorn C. Knollmann, Lufang Zhou, Jonathan P. Davis, Bin Liu 1164-pos Board B293 KINETICS AND MAPPING OF CALCIUM-DRIVEN CALMODULIN CONFOR MATIONS ON RYANODINE RECEPTORS. Bengt Svensson , Robyn T. Reb beck, Jingyan Zhang, Donald M. Bers, David D. Thomas, Razvan L. Cornea 1165-pos Board B294 GENE THERAPY STRATEGIES USING CRISPR/CAS9 FOR RYR1-RELATED MYOPATHIES. Mathilde Beaufils, Julie Brocard, Julien Faure, John Rendu, Isabelle Marty Intracellular Organelle Dynamics (Boards B295 - B298) 1166-pos Board B295 INVESTIGATING INSULIN VESICLE MATURATION PATHWAYS USING SOFT X-RAY TOMOGRAPHY. Aneesh Deshmukh , Shayan Mahmood, Kate L. White R. Marks 1161-pos

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