Biophysical Society 67th Annual Meeting Program Guide

Symposium: Allosteric Modulation of GPCRs

Room 6B

Chair Madan Babu, St. Jude Children’s Research Hospital, USA, Chair NOVEL PARADIGMS OF GPCR ACTIVATION. Celine Valant REVEALING STRUCTURAL MECHANISMS OF ALLOSTERIC MODULATION TO ENABLE THE DESIGN OF SAFE, EFFECTIVE GPCR TARGETED DRUGS. Ron O. Dror THE ‘HUNGER GAMES’ - STRUCTURAL STUDIES OF THE MC4 RECEPTOR REVEAL MECHANISM FOR SATIETY. Moran Shalev Benami DATA SCIENCE APPROACHES TO GPCR SIGNALING SYSTEMS. Madan Babu

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4:00 pm-6:00 pm

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4:00 pm-6:00 pm Platform: Spectroscopy and Imaging 4:00 pm-6:00 pm Platform: Ribosomes and Translation

Room 6C Room 6D Room 6E Room 6F Room 5AB Room 11AB

4:00 pm-6:00 pm Platform: Enzyme Function, Cofactors, and Post-Translational Modifications

D A Y

4:00 pm-6:00 pm Platform: TRP Channels

4:00 pm-6:00 pm Platform: Membrane Structure and Fusion

4:00 pm-6:00 pm Platform: Cell Mechanics, Mechanosensing, and Motility

6:00 pm-6:30 pm Dinner Meet-Ups

Lobby BC/Society Booth

6:00 pm-10:00 pm Publications Committee Meeting

Hilton, Indigo 202

Workshop: Computational Modeling of Binding Thermodynamics

Room 6C

Chair Carol Post, Purdue University, USA PROTEIN-LIGAND BINDING WITH MARTINI 3. Siewert Marrink BINDING FREE ENERGIES FROM THE POLARIZABLE AMOEBA FORCE FIELD. Jay Ponder PREDICTING PROTEIN-MEMBRANE INTERFACES USING MOLECULAR SIMULATIONS AND ENSEMBLE MACHINE LEARNING. Zoe Cournia ADVANCING DRUG DISCOVERY WITH ACCURATE AND RELIABLE PROTEIN-LIGAND BINDING FREE ENERGY CALCULATIONS. Lingle Wang COMPUTATION OF CONFORMATIONAL TRANSITIONS AND ACTIVATION OF SRC TYROSINE KINASE. Carol Post Chair Giovanni Maglia, University of Groningen, The Netherlands PROBING PROTEIN STRUCTURAL DYNAMICS AT THE SINGLE-MOLECULE LEVEL BY NANOPORE TWEEZERS. Min Chen ULTRA-PRECISE SINGLE-MOLECULE NANOPORE TOOL TO WATCH ENZYMES AT WORK. Jens H. Gundlach NANOPORES AS VERSATILE SINGLE-MOLECULE TOOLS -FROM DNA TURBINES TO PROTEIN SEQUENCING. Cees Dekker NEW PORES, NEW TRICKS. Giovanni Maglia Chair Nien-Hui Ge, University of California, Irvine, USA STIMULATED RAMAN SCATTERING MICROSCOPY: THE NEXT FRONTIER OF OPTICAL IMAGING. Wei Min CHARACTERIZING PROTEIN CONFORMATIONAL ENSEMBLES AND DYNAMICS WITH 2D IR SPECTROSCOPY. Andrei Tokmak off REACTIONS ON THE LIPID MEMBRANE INTERFACE PROBED BY NONLINEAR VIBRATIONAL SUM FREQUENCY GENERATION SPECTROSCOPY. Shen Ye BIOLOGICAL IMAGING WITH HYPERSPECTRAL VIBRATIONALLY RESONANT SUM-FREQUENCY GENERATION MICROSCOPY. Nien-Hui Ge Chair Joseph Puglisi, Stanford University, USA OPTIMIZING SINGLE-MOLECULE EXPERIMENTAL APPROACHES FOR THE STUDY OF COMPLEX PROTEIN ASSEMBLIES ON DNA. Nynke H. Dekker SINGLE MOLECULE MANIPULATION AND IMAGING OF COMPLEX DNA-PROTEIN INTERACTIONS. Gijs Wuite RNA STRUCTURE DIRECTS THE TARGETING SPECIFICITY OF CAS13D. Ilya Finkelstein SINGLE-MOLECULE INVESTIGATION OF LIGAND-ACTIVATION MECHANISMS FOR MEMBRANE PROTEINS IN CELL-DERIVED NANOVESICLES. Marcel P. Goldschen-Ohm ANIMATING BIOLOGICAL MECHANISM. Joseph Puglisi Workshop: Developments in Nanopore Biosensors Workshop: Vibrational Tools for Biomolecular and Cellular Studies Workshop: High Throughput Single Molecule Spectroscopy

7:30 pm-9:30 pm

Room 6D

7:30 pm-9:30 pm

Room 6E

7:30 pm-9:30 pm

Room 6F

7:30 pm-9:30 pm

8:00 pm-10:00 pm SOBLA (The Society for Latinoamerican Biophysicists) Meeting

Room 8

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