Biophysical Society 67th Annual Meeting Program Guide

Platform TRP Channels 4:00 pm - 6:00 pm, Room 6F

1547-Plat 5:30 pm PRINCIPLES OF MITORIBOSOMAL SMALL SUBUNIT ASSEMBLY IN EU KARYOTES. Chloe L. Burnside , Nathan Harper, Sebastian Klinge 1548-Plat 5:45 pm UNSUPERVISED VOXEL-BASED SEGMENTATION REVEALS LANDSCAPE OF BACTERIAL RIBOSOME LARGE SUBUNIT EARLY ASSEMBLY. Kai Sheng , Ning Li, Jessica N. Rabuck-Gibbons, Xiyu Dong, Dmitry Lyumkis, James R. Williamson Platform

T U

Co-Chairs Paul DeCaen, Northwestern University, USA Roberta Gualdani, University Catholique Louvain, Belgium 1557-Plat 4:00 pm EXPLORING FUNCTIONAL CONSERVATION OF THE COOLING AGENT BINDING SITE IN THE TRANSIENT RECEPTOR POTENTIAL MELASTATIN SUBFAMILY. Katherine Huffer , Kenton Swartz 1558-Plat 4:15 pm HIGH-THROUGHPUT INVESTIGATION OF TEMPERATURE- AND LIGAND ACTIVATION OF THE TRPM8 CHANNEL. Ashlin Turner, Ashley Vazhavilla, Andres Jara-Oseguera 1559-Plat 4:30 pm HIGH-SPEED AFM REVEALS A RARE STRUCTURAL STATE FOR TRPV3. Shifra Lansky , John M. Betancourt, Simon Scheuring 1560-Plat 4:45 pm GENETICALLY-ENCODED BRET PROBES ENLIGHT LIGAND BIAS-INDUCED VARIABLE ION SELECTIVITY IN TRPV1 AND P2X5/7. Yann Chappe, Sandra Pierredon, Alexandre Joushomme, Pablo Molle, André Garenne, Anne Canovi, Solène Barbeau, Florence Poulletier De Gannes, Annabelle Hurtier, Isabelle Lagroye, Thomas Ducret, Jean-François Quignard, Vincent Compan, Yann Percherancier 1561-Plat 5:00 pm ENERGETICS AND STRUCTURAL DETERMINATIONS OF TRPV1 ACTIVA TION BY VANILLOIDS. Shisheng Li , Phuong T. Nguyen, Vladimir Yarov Yarovoy, Jie Zheng 1562-Plat 5:15 pm Travel Award Winner A TR(I)P THROUGH TRPA1 MECHANOSENSITIVITY. Justyna B. Startek , Alina Milici, Thomas Voets, Karel Talavera 1563-Plat 5:30 pm A TRPM7 MUTATION LINKED TO FAMILIAL TRIGEMINAL NEURALGIA: OMEGA CURRENT AND HYPEREXCITABILITY OF TRIGEMINAL GANGLION NEURONS. Roberta Gualdani , Philippe Gailly, Jun-Hui Yuan, Xavier Yerna, Giulia Di Stefano, Andrea Truini, Giorgio Cruccu, Sulayman D. Dib Hajj, Stephen G. Waxman 1564-Plat 5:45 pm PRIMARY CILIA TRP CHANNELS REGULATE HIPPOCAMPAL EXCITABILITY. Thuy Vien, My C. Ta, Paul G. DeCaen Platform Membrane Structure and Fusion 4:00 pm - 6:00 pm, Room 5AB Co-Chairs Milka Doktorova, University of Virginia, USA Kailu Yang, Stanford University, USA 4:00 pm DEMONSTRATION, USING NOVEL SUPPORTED PLANAR ENDOSOMAL MEMBRANES (SPEM), THAT FURTHER CATHEPSIN ACTION AUGMENTS THE FUSION ACTIVITY OF THE PRIMED (19-KDA) EBOLA VIRUS GLYCO PROTEIN. Laura Odongo , Volker Kiessling, Judith M. White, Lukas K. Tamm 1566-Plat 4:15 pm DRUG DISCOVERY TARGETING SARS-COV-2 MEMBRANE FUSION. Kailu Yang , Chuchu Wang, Alex J.B. Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J. Eisen, K. Ian White, Richard Pfuetzner, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tomas Kirchhausen, Axel T. Brunger 1565-Plat

E S

Enzyme Function, Cofactors, and Post-Translational Modifications 4:00 pm - 6:00 pm, Room 6E

D A Y

Co-Chairs Simou Sun, University of California, Berkeley, USA Chu Zheng, Stanford University, USA

1549-Plat 4:00 pm ULTRAFAST REPAIR DYNAMICS OF CPD PHOTOLESION ISOSTERES BY DNA PHOTOLYASE. Debanjana Chakraborty , Chao Yang, Lijuan Wang, Dongping Zhong 1550-Plat 4:15 pm SMALL MOLECULE CO-SOLVENTS ENHANCE ACTIVITY OF SARS-COV-2 MAIN PROTEASE THROUGH A DIELECTRIC EFFECT. Marquise G. Crosby 1551-Plat 4:30 pm ELUCIDATING SIGNAL TRANSDUCTION PATHWAY IN LIGHT-ACTIVATED ADENYLYL CYCLASE USING UNNATURAL amINO ACID MUTAGENESIS. Samruddhi S. Jewlikar , Jinnette Tolentino, Madeeha Ali, Peter J. Tonge 1552-Plat 4:45 pm PHOSPHORYLATION-DEPENDENT KINETICS OF ZAP70 ACTIVATION AND DISSOCIATION. Simou Sun , Eric Gai, Lap Jung Nugent Lew, Neil (Hyu neil) Kim, Jay T. Groves 1553-Plat 5:00 pm DIRECTLY MAPPING THE O-SULFATION SITES WITHIN CCR2 VIA AN ENGINEERED NANOPORE. Hongyan Niu , Meng-Yin Li, Xue-yuan Wu, Travel Award Winner USING SINGLE-MOLECULE FLUORESCENCE TECHNIQUES TO UNDER STAND THE ENZYMATIC CYCLE OF SEX-BIASED RNA HELICASES DDX3X AND DDX3Y. am ber M. Yanas , Him Shweta, Michael Owens, Yale E. Goldman, Kathy F. Liu 1555-Plat 5:30 pm LON PROTEASE DEGRADES STABLE SUBSTRATES SLOWLY BUT WITH ENHANCED PROCESSIVITY, REDEFINING THE MODEL OF A STRONG AND ROBUST AAA+ PROTEASE. Meghann Kasal , Hema Chandra Kotamarthi, Madeline M. Johnson, Hannah Stephens, Matthew J. Lang, Robert T. Sauer, Tania Baker 1556-Plat 5:45 pm AN ANSWER TO THE FIBRINOLYSIS “CHICKEN-OR-THE-EGG” PROBLEM: THE UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) CAN AUTOAC TIVATE. Constanza Torres-Paris , Pingyu Chen, Harriet J. Song, Elizabeth A. Komives Yi-Tao Long 1554-Plat 5:15 pm

104