Biophysical Society 67th Annual Meeting Program Guide

1837-Pos Board B242 SPATIALLY DISCORDANT ALTERNANS OCCURRING WHEN CARDIAC TISSUE IS PACED ALTERNATIVELY FROM TWO SITES. Tymoteusz F. Bak , Daisuke Sato 1838-Pos Board B243 CHARACTERIZATION OF ORAI1 G100S/+ MOUSE MODEL OF TUBULAR AG GREGATE MYOPATHY. Nan Zhao , Antonio Michelucci, Miao He, Sundeep Malik, Laura Pietrangelo, Simona Boncompagni, Feliciano Protasi, Robert Board B244 PKD1 IS NECESSARY FOR FULL CARDIAC ANGII-INDUCED HYPERTRO PHY BUT NOT FOR FULL ACUTE ANGII-INDUCED CALCIUM HANDLING CHANGES. Juliana Mira Hernandez , Christopher Y. Ko, Avery Mandel, Erin Y. Shen, Ashley R. Christensen, Julie Bossuyt, Donald M. Bers 1840-Pos Board B245 EFFECTS OF CIGARETTE SMOKE EXTRACTS (COMBUSTIBLE AND HEATED TOBACCO) ON RAT AND HUMAN IPS CELL-DERIVED CARDIOMYO CYTES. Jumpei Yasuda, Sakiko Matsumura, Takuya Notomi, I-Shan Chen, Takahiro Horinouchi, Tomoe Y. Nakamura 1841-Pos Board B246 14-3-3 REGULATES CARDIAC CA V 1.2 CLUSTERING, EXPRESSION, AND TRAFFICKING. Heather Spooner , Maartje F. Westhoff, Husna Ibrahim khail, Aleena Yarovaya, Eamonn J. Dickson, Rose E. Dixon 1842-Pos Board B247 RYANODINE RECEPTOR HYPERACTIVITY PROMOTES MITOCHONDRIAL DYSFUNCTION VIA CALPAIN-DEPENDENT OPA1 PROTEOLYSIS. Shanna Hamilton , Radmila Terentyeva, Roland Veress, Fruzsina Perger, Zuzana Nichtova, Benjamin Martin, Sandor Gyorke, Andriy E. Belevych, Gyorgy Csordas, Dmitry Terentyev Cardiac, Smooth, and Skeletal Muscle Electrophysiology (Boards B248 - B271) 1843-Pos Board B248 A SWITCH IN FXYD PROTEINS DYSREGULATES NKA IN DILATED CARDIO MYOPATHY. John Q. Yap , Taylor Phillips, Jaroslava Seflova, Jacob Cunning ham, Seth L. Robia 1844-Pos Board B249 KCNH2 ENCODES A NUCLEAR-TARGETED POLYPEPTIDE THAT MEDIATES HERG1 CHANNEL GATING AND EXPRESSION. Abhilasha Jain , Olivia Stack, David K. Jones, Chiamaka Ukachukwu, Francisco G. Sanchez-Conde, Eric jimenez Vazquez, Shreya Salwi, Saba Ghodrati 1845-Pos Board B250 DATA-DRIVEN, PATIENT-SPECIFIC SIMULATIONS OF LONG-TERM HEART RATE VARIABILITY AND CARDIAC ALTERNANS FORMATION. Vrishti M. Phadumdeo , Brianna L. Mallare, Thomas J. Hund, Seth H. Weinberg 1846-Pos Board B251 MODELING INCOMPLETE PENETRANCE IN LONG QT SYNDROME TYPE 3 (LQT3) THROUGH ION CHANNEL HETEROGENEITY: AN IN SILICO POPULA TION STUDY . Jacob A. Miller , Seth H. Weinberg, Nicolae Moise 1847-Pos Board B252 THE HERG PAS DOMAIN: A MAJOR REGULATOR OF I KR AND A PROMIS ING ANTI-ARRHYTHMIC DRUG TARGET​. Chiamaka U. Ukachukwu , Eric N. Jiménez-Vázquez, Abhilasha Jain, David K. Jones 1848-Pos Board B253 PLASMA MEMBRANE CURVATURE PROMOTES ER-PM CONTACT FORMA TION MEDIATED BY JUNCTOPHILIN. Yang Yang , Bianxiao Cui T. Dirksen 1839-Pos

1849-Pos Board B254 MODELING SEX DIFFERENCES IN HUMAN ATRIAL MYOCYTE STRUCTURAL AND CA 2+ HANDLING PROPERTIES: IMPACT ON CA 2+ -DRIVEN ARRHYTH MIA. Xianwei Zhang , Yixuan Wu, Charlotte Smith, Stefano Morotti, Eleonora Grandi, Haibo Ni 1850-Pos Board B255 AUTOCORRELATION-BASED ALGORYTHM TO DETECT ALTERNANS IN CALCIUM BUFFERED VENTRICULAR MYOCYTES. Mark Warren , Steven Poelzing 1851-Pos Board B256 Travel Award Winner SEX DIFFERENCES IN ELECTROPHYSIOLOGY OF THE INTACT ATRIA. Char lotte E.R. Smith , Amanda M. Guevara, Lianguo Wang, Eleonora Grandi, Crystal M. Ripplinger 1852-Pos Board B257 CALCIUM INHIBITS THE FUNNY CURRENT (I F )IN SINOATRIAL MYO CYTES. Colin H. Peters , Diego A. Peraza, Lucas M. Blecker, John Bankston, Cathy Proenza 1853-Pos Board B258 ROLE OF AMPK PATHWAY INACTIVATION IN HIGH FAT DIET RELATED CARDIAC ELECTROPHYSIOLOGICAL REMODELING. Michael W. Rudokas , Marine Cacheux, Xiaohong Wu, Madelyn E. Hummel, Lawrence H. Young, Fadi G. Akar 1854-Pos Board B259 PREDICTING PATIENT-SPECIFIC SINGLE-CELL PARAMETERS IN COMPU TATIONAL CARDIAC MODELS USING MACHINE LEARNING. Lucas Lee , Jonathan D. Moreno, Jonathan R. Silva 1855-Pos Board B260 Travel Award Winner COMPENSATORY CALCIUM HANDLING MAY UNDERLIE INCREASED ARRHYTHMIA SUSCEPTIBILITY OF SARCOSPAN-DEFICIENT MICE AFTER ISCHEMIA-REPERFUSION INJURY. Aida Rahimi Kahmini , Isela C. Valera, Alexis Cejas Carbonell, Julia Prascak, Florence Mumbi, Michelle S. Parvati yar, Hyun S. Hwang 1856-Pos Board B261 NEAR INFRARED VOLTAGE SENSITIVE DYES BASED ON CHROMENE ELEC TRON DONORS. Ping Yan, Valentina Biasci, Giuliana Judge, Corey D. Acker, Alexa Monroe, Leonardo Sacconi, Leslie M. Loew 1857-Pos Board B262 Travel Award Winner 3D SPATIAL MODELING OF SINOATRIAL NODE CELLS REVEALS A CRITICAL ROLE OF SUBCELLULAR RYANODINE RECEPTOR DISTRIBUTION IN PACE MAKER AUTOMATICITY. Haibo Ni , Xianwei Zhang, Yixuan Wu, Di Lang, Stefano Morotti, Alexey V. Glukhov, Eleonora Grandi 1858-Pos Board B263 SEX-SPECIFIC CONTRIBUTION OF SMALL-CONDUCTANCE CA 2+ -ACTIVATED K + CURRENT TO ATRIAL ELECTROPHYSIOLOGY AND ARRHYTHMOGEN ESIS. Nathaniel T. Herrera , Haibo Ni, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi 1859-Pos Board B264 SINOATRIAL NODE CELLS AND TISSUE OPERATE VIA STOCHASTIC RESO NANCE. Victor A. Maltsev , Alexander V. Maltsev, Anna Maltsev, Edward G. Lakatta, Michael D. Stern 1860-Pos Board B265 EXPLORING THE PATHOPHYSIOLOGICAL ROLE OF THE PLN-R14DEL MUTA TION IN A NOVEL HETEROZYGOUS MOUSE MODEL OF DILATED CARDIO MYOPATHY. Francesco Lodola , Claudia Maniezzi, Marem Eskandr, Chiara Florindi, Rudolf A. de Boer, Herman Silljé, Antonio Zaza 1861-Pos Board B266 INPUT OF EXPRESSED HERG CURRENT INTO A COMPLEX NEURON IN SILI CO CARDIAC ATRIAL CELL: IMPLICATIONS FOR CARDIOTOXICITY SCREEN ING. Mark W. Nowak , Leigh Korbel, Alex Kane, Brian K. Panama, Michael L. Hines, Nicholas T. Carnevale, Glenna C. Bett, Randall L. Rasmusson

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