Biophysical Society 67th Annual Meeting Program Guide

2034-Pos Board B439 SCN1A GAIN OF FUNCTION CAUSES INTERNEURON HYPEREXCITABILITY AND NETWORK INSTABILITY THROUGH INHIBITORY SYNAPTIC PLASTICITY IN EARLY INFANTILE ENCEPHALOPATHY. Geza Berecki , Alexander Bryson, Steven Petrou 2035-Pos Board B440 BEHIND SPORADIC ALS: A BIOPHYSICAL CHARACTERIZATION OF MOTOR NEURONS IN HEALTH AND DISEASE. Martina Bonucci , Güney Akbalik, Yi Shuan Tseng, Hemali Phatnani, Liam J. Holt 2036-Pos Board B441 SUPRAMOLECULAR ORGANIZATION OF THE POSTSYNAPTIC DENSITY FOR TRANS-SYNAPTIC ALIGNMENT IN EXCITATORY SYNAPSE OBSERVED BY CRYO-ELECTRON TOMOGRAPHY. Rong Sun , Liana Wilson, Mariam Haider, Xinyi Wang, Baris Alten, Qiangjun Zhou 2037-Pos Board B442 STRUCTURE-FUNCTION INSIGHTS INTO THE ROLE OF D-AMINO ACID OXIDASE MUTATIONS IMPLICATED IN AMYOTROPHIC LATERAL SCLERO SIS. Shumayila Khan , James Gomes Molecular Dynamics II: Method Development (Boards B443 - B472) 2038-Pos Board B443 THE MARTINI 3 ECOSYSTEM FOR COARSE-GRAINED SIMULATIONS. Fabian Grunewald , Paulo Cesar T. Souza, Siewert J. Marrink 2039-Pos Board B444 AN EVALUATION OF FORCE FIELD ACCURACY FOR THE MINI-PROTEIN CHIGNOLIN USING MARKOV STATE MODELS. TimMarshall , Robert Raddi, Vincent Voelz 2040-Pos Board B445 SELF-GUIDED MOLECULAR DYNAMICS SIMULATION BASED ON CONCERT ED MOVEMENT. Xiongwu Wu , Bernard R. Brooks 2041-Pos Board B446 BUILDING A COMMUNITY-DRIVEN ECOSYSTEM FOR FAST, REPRODUCIBLE, AND REUSABLE MOLECULAR SIMULATION ANALYSIS USING MDANALY SIS. Irfan Alibay , Jonathan Barnoud, Oliver Beckstein, Richard J. Gowers, Philip R. Loche, Hugo MacDermott-Opeskin, Micaela Matta, Fiona B. Naughton, Tyler Reddy, Lily Wang 10 2042-Pos Board B447 HYPERSOUND-PERTURBED MOLECULAR DYNAMICS SIMULATION FOR ACCELERATING SLOW BIOMOLECULAR INTERACTION PROCESSES. Mitsugu Araki , Yasushi Okuno 2043-Pos Board B448 EXTRACELLULAR PROTEOGLYCANS: A MULTISCALE COMPUTATIONAL STUDY. Saber Shakibi , Patrick R. Onck, Erik Van der Giessen 2044-Pos Board B449 DEVELOPMENT AND BENCHMARKING OF AN OPEN, SELF-CONSISTENT FORCE FIELD FOR PROTEINS AND SMALL MOLECULES FROM THE OPEN FORCE FIELD INITIATIVE. Chapin E. Cavender , Pavan K. Behara, Simon Boothroyd, David L. Dotson, Joshua T. Horton, Joshua A. Mitchell, Ivan Pu lido, MatthewW. Thompson, Jeffrey Wagner, Lily Wang, John D. Chodera, Daniel J. Cole, David L. Mobley, Michael R. Shirts, Michael K. Gilson 2045-Pos Board B450 THE ONSET OF WHOLE-CELL MODELING USING THE MARTINI FORCE FIELD. Jan A. Stevens , Fabian Grunewald, Marco van Tilburg, Zane R. Thornburg, Benjamin R. Gilbert, Troy A. Brier, Zaida Luthey-Schulten, Siewert J. Marrink

2021-Pos Board B426 USING GEOMETRY AND BIOMECHANICS TO UNDERSTAND AORTIC PA THOLOGY AND ENDOVASCULAR AORTIC REPAIR OUTCOMES. Kameel Kha baz, Karen Yuan, Kathleen Cao , Sanjeev Dhara, Žiga Donik, Junsung Kim, Willa Li, Blessing Nnate, Seth Sankary, M. Alyssa Varsanik, Janez Kram berger, Cheong Jun Lee, Ross Milner, Nhung Nguyen, Luka Pocivavsek 2022-Pos Board B427 Travel Award Winner A SYNTHETIC BIOLOGY TOOL FOR CONTACT-DEPENDENT SYNTHETIC CELL COMMUNICATION. Hossein Moghimianavval , Kyle Loi, Allen Liu 2023-Pos Board B428 NUCLEOCYTOPLASMIC TRANSPORT DETERMINES THE BIOPHYSICAL PROPERTIES IN THE NUCLEUS. Yi-Shuan Tseng , Liam J. Holt Molecular and Cellular Neuroscience (Boards B429 - B442) 2024-Pos Board B429 THE ROLE OF NAV1.9 IN THE SENSORY PERCEPTION OF ITCH. Wayra Brackx 2025-Pos Board B430 AGING MICROGLIA AND PHAGOCYTOSIS. Emily R. Krueger 2026-Pos Board B431 ACTION POTENTIAL FIRING AND SENSORY TRANSDUCTION ARE SUS TAINED BY MEMBRANE POTENTIAL INSTABILITIES IN PERIPHERAL SEN SORY NEURONS. Enrique (Quique) Velasco Serna , Julio Alvarez, Víctor M. Meseguer Vigueras, Juana Gallar, Karel Talavera 2027-Pos Board B432 SYNGAP LLPS CONDENSATES AS THE BASIC PLATFORM FOR RECRUIT ING PSD95 AND RECEPTOR OLIGOMERS FOR GENERATING NEURONAL EXCITATORY SYNAPSES. Saahil Acharya , Taka A. Tsunoyama, Christian Hoffmann, Gerard Aguilar, Irina Meshcheryakova, Yuri L. Nemoto, Aya Nakamura-Norimoto, Takahiro Fujiwara, Dragomir Milovanovic, Akihiro Kusumi 2028-Pos Board B433 PROBING SYNAPTIC DISTRIBUTION AND ARRANGEMENT OF NATIVE SURFACE AMPARS IN MOUSE BRAIN SLICES WITH 3D SUPERRESOLUTION MICROSCOPY. Rohit M. Vaidya , Duncan L. Nall, Donghan Ma, Fang Huang, Shiegeki Kiyonaka, Itaru Hamachi, Hee Jung Chung, Paul R. Selvin 2029-Pos Board B434 EVIDENCE FOR LONG-TERM POTENTIATION IN LIPID MEMBRANES. Haden L. Scott , Dima Bolmatov, Zening Liu, Jacob Kinnun, Benjamin Doughty, Ralph Lydic, Robert Sacci, Charles P. Collier, John Katsaras 2030-Pos Board B435 CONFORMATION OF NEUROFILAMENT HEAVY CHAIN EFFECT ON NEURO FILAMENT-NEUROFILAMENT ASSOCIATION AND BUNDLING. Ibtissem Derouiche 2031-Pos Board B436 OPTICAL IMAGING OF SYNAPTIC ACTIVITY IN AUDITORY HAIR CELLS. Martín A. Toderi , Dzmitry Vaido, Dolores Bozovic 2032-Pos Board B437 DECIPHERING THE BIOPHYSICAL GATING PROPERTIES OF AMPA RECEP TORS BY 2,3-BENZODIAZEPINE DERIVATIVES. Sosana S.M. Bdir , Moham mad S. Qneibi 2033-Pos Board B438 MECHANICAL FORCES PROMOTE ACTIN-MEDIATED STRUCTURAL PLAS TICITY. Mayte Bonilla Quintana , Padmini Rangamani

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