Biophysical Society 67th Annual Meeting Program Guide

Platform Condensates in Physiology and Disease 8:15 am - 10:15 am, Room 6C Co-Chairs Meredith Jackrel, Washington University in St. Louis, USA Sarah Woodson, Johns Hopkins University, USA 2147-Plat 8:15 am RESTRICTING INTERMOLECULAR INTERACTIONS AMONG COMPLEMEN TARY SEQUENCES IS REQUIRED FOR THE SPECIFICITY OF HOMOTYPIC MRNA ASSEMBLY. Siran Tian , Ziqing Ye, Silvi Rouskin, Tatjana Trcek 2148-Plat 8:30 am DIRECT OBSERVATION OF RNA STRUCTURE AND DYNAMICS IN REPEAT RNA ASSEMBLIES USING SINGLE MOLECULE FLUORESCENCE MICROS COPY. Roumita Moulick , Margaret L. Rodgers, Sarah A. Woodson 2149-Plat 8:45 am Travel Award Winner EBOLA VIRAL FACTORIES ARE BIOMOLECULAR CONDENSATES WITH SPE CIALIZED ASSEMBLY DYNAMICS FOR VIRAL RNA SYNTHESIS. Jingru Fang , Guillaume Castillon, Sebastien Phan, Sara McArdle, Chitra Hariharan, Mark Ellisman, Erica Ollmann Saphire 2150-Plat 9:00 am NUCLEAR PHASE SEPARATION DIRECTS HOX TRANSCRIPTION IN ACUTE MYELOID LEUKEMIA. Gandhar K. Datar , Archish Anand, Marwa Sadek, Christina Dollinger, English Laserna, Lorenzo Brunetti, Nidhi Sahni, Marga ret Goodell, Joshua A. Riback 2151-Plat 9:15 am EFFECT OF A MEMBRANE PROTEIN CONDENSATION PHASE TRANSI TION ON REACTION-DIFFUSION KINETICS. L.J. Nugent Lew , Joseph B. DeGrandchamp, Henry T. Phan, Chun-Wei Lin, He Ren, Albert Lee, Jay T. Groves 2152-Plat 9:30 am INTERFACE RESISTANCE OF BIOMOLECULAR CONDENSATES. Yoyo Jiang , Andrew Pyo, Clifford P. Brangwynne, Howard A. Stone, Ned S. Wingreen, Yaojun Zhang 2153-Plat 9:45 am MOLECULAR DETERMINANTS AND MODIFIERS OF THE TOXICITY, CON DENSATE DYNAMICS, AND DROPLET MORPHOLOGY OF THE ALS/FTD ASSOCIATED PROTEIN MATRIN-3. Meredith Jackrel 2154-Plat 10:00 am DEMIXING OF DISTINCT RIBONUCLEOPROTEIN CONDENSATES IS UNDER DYNAMICAL CONTROL. Rohit V. Pappu , Andrew Z. Lin, Kiersten M. Ruff, Ameya P. Jalihal, Furqan Dar, Ammon E. Posey, Matthew R. King, Jared M. Lalmansingh, Amy S. Gladfelter Platform RNA Structure and Dynamics 8:15 am - 10:15 am, Room 6D Co-Chairs Kush Coshic, University of Illinois Urbana-Champaign, USA Yuan Yang, University of California, USA 8:15 am STRUCTURAL BASIS OF RNA CONFORMATIONAL SWITCHING IN THE TRANSCRIPTIONAL REGULATOR 7SK RNP. Yuan Yang , Shiheng Liu, Sylvain Egloff, Catherine D. Eichhorn, Tanya Hadjian, James Zhen, Tamás Kiss, Hong Zhou, Juli Feigon 2156-Plat 8:30 am UNDERSTANDING COOPERATIVITY EFFECTS IN RNA STRUCTURE PROBING EXPERIMENTS. Emma Bose, Alisha Jones 2155-Plat

Wednesday, February 22 New Council Meeting 8:00 am - 11:00 am, Room 17B Poster Viewing 8:00 am - 3:00 pm, Exhibit Hall BC Symposium

W E

D N

Biophysics of Mitosis 8:15 am - 10:15 am, Room 6A

E S

Chair Mary Elting, North Carolina State University, USA 2139-Symp 8:15 am

D A Y

ACTION AT A DISTANCE ALONG THE MICROTUBULE COUPLES KINESIN MOTORS. Sithara Wijeratne, Shane A. Fiorenza, Alex Neary, Radhika Subramanian, Meredith Betterton 2140-Symp 8:45 am NAEGLERIA ’S MITOTIC SPINDLES ARE BUILT FROM UNIQUE TUBULINS AND ASSOCIATED MICROTUBULE BINDING PROTEINS. Andrew Kennard, Katrina Velle, Lillian Fritz-Laylin 2141-Symp 9:15 am BUILDING THE CYTOKINETIC RING: FROMMOLECULAR MECHANISMS TO CELLULAR FUNCTION. Dimitrios Vavylonis 2142-Symp 9:45 am DESTRUCTIVE TESTING ON MITOTIC MACHINERY: PROBING THE ME CHANICS OF FISSION YEAST CELL DIVISION BY LASER ABLATION. Mary W. Elting Symposium Mechanotransduction Complex in Hair Cells 8:15 am - 10:15 am, Room 6B Chair Robert Fettiplace, University of Wisconsin–Madison, USA 2143-Symp 8:15 am TOWARDS AN ATOMISTIC MODEL OF THE VERTEBRATE INNER-EAR TRANSDUCTION APPARATUS. Marcos Sotomayor 2144-Symp 8:45 am FUNCTION AND REGULATION OF TMC1, LHFPL5, AND TMIE IN AUDITORY MECHANOTRANSDUCTION COMPLEX. Xiaojie Yu, Yulin Li, Wanying Feng, Pingbo Huang 2145-Symp 9:15 am REGULATION OF MEMBRANE HOMEOSTASIS BY TMC1 MECHANOELEC TRICAL TRANSDUCTION CHANNELS. Angela Ballesteros Morcillo , Kenton J. Swartz 2146-Symp 9:45 am THE CONDUCTANCE OF TMC1-CONTAINING MECHANOTRANSDUCER CHANNELS AND THE ROLES OF LHFPL5 AND TMIE IN COCHLEAR HAIR CELLS. Robert Fettiplace

131