Biophysical Society 67th Annual Meeting Program Guide

Protein Structure, Prediction, and Design (Boards B26 - B58) 2276-Pos Board B26 DE NOVO DESIGN OF Β-BARREL NANOPORE WITH GLY-KINK TOWARDS SINGLE-MOLECULE DETECTION. Ikuro Mizoguchi 2277-Pos Board B27 ADAPTATIONS OF PROTEINS, RNA AND DNA TO EXTREME TEMPERA TURES, SALINITY AND PH. Aidana Amangeldina , Zhen Wah Tan, Igor N. Berezovsky 2278-Pos Board B28 Travel Award Winner OPTIMIZING THE FUNCTION AND DYNAMICS OF DE NOVO DESIGNED FLUORESCENT Β-BARREL PROTEINS. Justin P. Nguyen , Tyla Holoman, Jaime Cardenas, Colleen Carrigan, Colin A. Smith 2279-Pos Board B29 QUANTIFYING OBSCURIN’S IMPACT ON EPITHELIAL CELL AREA, PERIM ETER & LOCALIZATION WITH THE CELL MEMBRANE. Mason F. Ong , Callie Miller, Nathan T. Wright 2280-Pos Board B30 PREDICTING HYDRATION PROPERTIES OF PROTEINS. Britnie Carpentier , Shikha Nangia 2281-Pos Board B31 ARCHITECTURE AND FUNCTION OF THE MEIOTIC METAZOAN HORMAD CHROMATIN BINDING REGION (CBR). Alyssa A. Rodriguez 2282-Pos Board B32 A TOOLKIT OF CUSTOMISED PROTEIN SENSORS FOR INTERROGATING MECHANICAL FORCES IN THE CELL. Maria Zacharopoulou , Marie Synake wicz, Janet R. Kumita, Mohsin Mubarak Naqvi, Laura S. Itzhaki 2283-Pos Board B33 MUTATIONAL FITNESS LANDSCAPE OF HUMAN INFLUENZA H3N2 NEUR AMINIDASE. Ruipeng Lei , Andrea Hernandez Garcia, Timothy J.C. Tan, Qi Wen Teo, Yiquan Wang, Xiwen Zhang, Shitong Luo, Satish K. Nair, Jian Peng, Nicholas C. Wu 2284-Pos Board B34 Withdrawn IDENTIFICATION AND PREDICTION OF FOLD-SWITCHING PROTEINS. Lauren L. Porter , Joseph W. Schafer, Devlina Chakravarty, Allen Kim, Swechha Rimal, Loren Looger, Ananya K. Majumdar, Mary Starich, Marie Paule Strub 2285-Pos Board B35 DE NOVO DESIGN OF BETA HAIRPIN PEPTIDES WITH CUSTOM INSTALLED HALOGEN-BONDING GROUPS. Thi Dung Nguyen , Vincent Voelz 2286-Pos Board B36 INVESTIGATING THE STRUCTURAL AND DYNAMICAL BASIS FOR ION AFFINITY IN THE ION-BINDING SITES OF SIGNALING PROTEINS. Eman Alasadi 2287-Pos Board B37 GENERATIVE MODELING OF SHORT, DISORDERED PROTEINS WITH HO MOGENEOUS SEQUENCE COMPOSITION. Ishan Taneja , Keren Lasker 2288-Pos Board B38 DESIGN AND CHARACTERIZATION OF HYPER STABLE VARIANT OF HUMAN FIBROBLAST GROWTH FACTOR1 (HFGF1). Shiva Sonnaila 2289-Pos Board B39 COMPUTATIONAL MODELING AND MOLECULAR MAPPING OF SERINE PROTEASE INHIBITOR FAMILY A5 (SERPINA5) STRUCTURE, ASSOCI ATED WITH TAU EXPRESSION AND ALZHEIMER’S DISEASE. Oleksandr V. Savytskyi , Tiffany N.H. Sirmans, Mathew A. Coban, Caleb A. Weber, Melissa E. Murray, Thomas R. Caulfield

2290-Pos Travel Award Winner PHOTOREGULATION OF IL-24/IL-20R2 COMPLEX FORMATION USING A LIGHT-RESPONSIVE NON-CANONICAL AMINO ACID. Phuong Ngoc Pham , Jiří Zahradník, Gustavo Fuertes, Lucie Kolářová, Bohdan Schneider 2291-Pos Board B41 Travel Award Winner LOW INFORMATION NMR DATA GUIDED PROTEIN-PEPTIDE COMPLEX STRUCTURE DETERMINATION WITH MELDXMD. Arup Mondal , Alberto Perez, Gaetano T. Montelione 2292-Pos Board B42 ENCODING DYNAMICAL INFORMATION OF PROTEIN FROM NORMAL MODE ANALYSIS AS MULTIGRAPHS FOR FUNCTION PREDICTION BY GRAPH NEURAL NETWORKS AND HIGHLIGHTING FUNCTIONALLY-CRITI CAL RESIDUES. Yenlin Chen , Yuan Chiang, Wei-Han Hui, Shu-Wei Chang 2293-Pos Board B43 A DE NOVO -DESIGNED MINI-PROTEIN CAN INHIBIT FGFR SIGNALING IN AN ISOFORM-SPECIFIC MANNER. Sangwon Lee 2294-Pos Board B44 A MULTIPRONGED FOOTPRINTING MAP VALIDATES THE PREDICTED STRUCTURE OF STRESS BIOMARKER NEUROPEPTIDE Y (NPY) AND ITS BINDING WITH NOVEL PEPTIDE BINDERS. Rohit Jain , Erik R Farquhar, Janna Kiselar, David T. Lodowski, Mark R. Chance 2295-Pos Board B45 MOLECULAR ARCHITECTURE OF NUCLEOSOME REMODELING AND DEACETYLASE SUB-COMPLEXES BY INTEGRATIVE STRUCTURE DETERMI NATION. Shreyas M. Arvindekar , Matthew J. Jackman, Jason K.K. Low, Michael J. Landsberg, Joel P. Mackay, Shruthi Viswanath 2296-Pos Board B46 DESIGNING OCCLUDED-OPEN ENV-BASED IMMUNOGENS FOR HIV-1. Andrew T. DeLaitsch , Nathaniel Liendo, Pamela J. Bjorkman 2297-Pos Board B47 COMPUTATIONAL PROGNOSTIC EVALUATION OF ALZHEIMER’S DRUGS FROM FDA-APPROVED DATABASE THROUGH STRUCTURAL CONFORMA TIONAL DYNAMICS AND DRUG REPOSITIONING APPROACHES. Mubasher Hassan , Saba Shahzadi, Andrzej Kloczkowski 2298-Pos Board B48 STRUCTURAL FEATURES OF EWSR1 AFFECTING EWING’S SARCOMA. COMPUTATIONAL DOMAIN ASSEMBLY AND CONFORMATIONAL DYNAM ICS STUDIES. Saba Shahzadi , Mubashir Hassan, Andrzej Kloczkowski 2299-Pos Board B49 COMPUTATIONAL PROTEIN STRUCTURE ELUCIDATION FROM COVALENT LABELING MASS SPECTROMETRY DATA. Steffen Lindert 2300-Pos Board B50 Travel Award Winner COMPARATIVE DYNAMICS AND STRUCTURAL ANALYSIS OF EXTREMO PHILIC SERINE PROTEASES FROM DIVERSE ENVIRONMENTS. Elizabeth Diessner, Gemma R. Takahashi , Rachel W. Martin, Carter T. Butts 2301-Pos Board B51 Travel Award Winner VARIANT EFFECT PREDICTION USING STRUCTURE-INFORMED PROTEIN LANGUAGE MODELS. Yuanfei Sun , Yang Shen 2302-Pos Board B52 ATOMIC-LEVEL CHARACTERIZATION OF THE HUMAN IMMUNODEFI CIENCY VIRUS TYPE 1 ENVELOPE GLYCOPROTEINS USING MOLECULAR DYNAMIC SIMULATIONS. Stephanie M. Sauve , Maolin Lu, Mahmoud Moradi 2303-Pos Board B53 IN SILICO SIMULATIONS FOR PREDICTION AND MODELING OF PROTEIN ENGINEERING WITHIN CATALYTIC SUBUNIT OF DIRECT ELECTRON TRANS FER TYPE FAD GLUCOSE DEHYDROGENASE FOR INCREASES IN SUBSTRATE SPECIFICITY AND STRUCTURAL STABILITY. Joseph A. Kerrigan Jr , Koji Sode Board B40

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