Biophysical Society 67th Annual Meeting Program Guide

2465-Pos Board B215 EFFECTS OF FAMILIAL ALZHEIMER’S DISEASE MUTATIONS ON GAMMA SECRETASE ACTIVATION FOR CLEAVAGE OF AMYLOID PRECURSOR PRO TEIN. Hung N. Do, Sujan Devkota, Apurba Bhattarai, Michael S. Wolfe, Yinglong Miao 2466-Pos Board B216 COMPARING ELASTIC AND MOLECULAR MODELS OF MEMBRANE BENDING LOCAL TO SARS-COV-2 ENVELOPE PROTEIN FOR MECHANISTIC UNDERSTANDING. Jesse W. Sandberg , Grace H. Brannigan 2467-Pos Board B217 VOLTAGE SENSING BY DIPOLAR TRANSMEMBRANE PEPTIDES. Konark Bisht , Michael A. Lomholt, Himanshu Khandelia 2468-Pos Board B218 EFFECT OF AMYLOID-BETA AGGREGATION AND ABSORPTION ON LIPID DEMIXING IN MIXED ANIONIC/ZWITTERIONIC BILAYERS. Meenal Jain , Silvina Matysiak 2469-Pos Board B219 EQUILIBRIUM BINDING EQUATIONS FOR PERIPHERAL MEMBRANE BINDING PROTEINS. Daniel H. Kerr , Tiffany Suwatthee, Sofiya Maltseva, Miah J. Turke, Erin J. Adams, Ka Yee C. Lee 2470-Pos Board B220 MICROFLUIDIC FORMATION AND MANIPULATION OF OLA-BASED LIPO SOMES FOR SYNTHETIC BIOLOGY RESEARCH. Chang Chen , Ketan Ganar, Siddharth Deshpande 2471-Pos Board B221 QUANTITATIVE STUDY OF THE DYNAMICS AND ENERGETICS OF PEPTIDE LIPID MEMBRANE INTERACTION USING COARSE-GRAINED MOLECULAR DYNAMICS SIMULATIONS. Ryan Smith , Ioan Kosztin 2472-Pos Board B222 THE IMPACT OF LIPID PACKING DEFECTS ON ALPHA-SYNUCLEIN BIND ING TO LIPID MEMBRANES. Miah J. Turke , Benjamin R. Slaw, Daniel H. Kerr, Sofiya Maltseva, Krishna M. Raghavan, Ka Yee C. Lee 2473-Pos Board B223 UNCOVERING THE CONFORMATIONAL DYNAMICS OF DENGUE VIRUS AND ITS VIRUS-LIKE PARTICLES AS NOVEL VACCINE CANDIDATES. Jan K. Marzinek , Venkata Raghuvamsi Palur, Gielenny Salem, Fan-Chi Chen, Shang-Rung Wu, Peter J. Bond, Day-Yu Chao 2474-Pos Board B224 LIPID MODULATION OF MEMBRANE PROTEIN CONFORMATIONAL EQUI LIBRIA DOES NOT REQUIRE LIPID IMMOBILIZATION IN LONG-LASTING PROTEIN-LIPID COMPLEXES. Nathan Bernhardt , Janice L. Robertson, José D. Faraldo-Gómez 2475-Pos Board B225 PREDICTING PROTEIN-LIPID INTERACTIONS THROUGH MACHINE LEARNING METHODS EMPLOYING NEW TOKENIZATION TECH NIQUES. Carlos R. Cuellar Rodriguez , Emad Tajkhorshid Membrane Receptors and Signal Transduction (Boards B226 - B242) Board B226 BUILDING AN AFFINITY PANEL OF SYNTHETIC POLYCLONAL T-CELL RECEPTOR LIGANDS THAT MIMIC NATIVE PEPTIDE-MHC. Anand Vissa , Kiera B. Wilhelm, Brittany Stinger, Jay T. Groves 2477-Pos Board B227 COMPUTATIONAL CHARACTERIZATION OF THE BINDING MODE AND MECHANISM OF ACTION OF TRICYCLIC SMALL MOLECULES AT 5-HT1E AND 5-HT1F RECEPTORS. Bianca Fiorillo , Gregory Zilberg, Daniel Wacker, Marta Filizola 2476-Pos

2478-Pos Board B228 DISSECTING THE CONTRIBUTIONS OF EPITOPE ACCESSIBILITY IN B CELL ACTIVATION. Jessica P. Kuppan , Michael D. Vahey 2479-Pos Board B229 QUANTITATIVE FRET STUDIES OF EPHA2-LYN INTERACTIONS. Evgenia V. Azarova , Elena B. Pasquale, Kalina Hristova 2480-Pos Board B230 THE IMPACT OF ENDOPLASMIC RETICULUMMORPHOLOGY ON IRE1 PROTEIN CLUSTERING. Liam Kischuck , Aidan Brown 2481-Pos Board B231 UNDERSTANDING THE SPATIAL AND FUNCTIONAL LINK BETWEEN THE IL-2R AND TCR AT THE IMMUNOLOGICAL SYNAPSE. Jesusa Capera-Aragones , Lina Chen, Salvatore Valvo, Anish Suri, Raymond Moniz, Michael L. Dustin 2482-Pos Board B232 PHOSPHATIDYL SERINE PRECONDITIONS THE A 2A AR FOR G-PROTEIN COUPLING VIA A CONSERVED MOTIF ON TM6 AND TM7. LiamM. Sharp , Matthew T. Eddy, Naveen Thakur, Arka Prabha Ray, Edward R. Lyman 2483-Pos Board B233 MOLECULAR DETERMINANTS OF DISTINCTIVE OPIOID RECEPTOR SUB TYPE AFFINITIES. Antoni Marciniak , Darko Mitrovic, Lucie Delemotte 2484-Pos Board B234 AI-ASSISTED DE NOVO DESIGN OF SELECTIVE Κ-OPIOID RECEPTOR AN TAGONISTS FOR THE TREATMENT OF OPIOID ADDICTION. Letty Leslie Ann Salas Estrada , Davide Provasi, Joao Marcelo Lamim Ribeiro, Bianca Fiorillo, Marta Filizola 2485-Pos Board B235 DISSECTING DIFFUSION AND OLIGOMERIZATION DYNAMICS OF GPCRS IN LIVE CELLS USING SINGLE-PARTICLE TRACKING. Xiaohan Zhou , Claudiu C. Gradinaru 2486-Pos Board B236 COMPREHENSIVE ELUCIDATION OF DEVELOPMENTAL FUNCTIONS OF ARACHIDONIC ACID-DERIVED LIPID MEDIATORS IN ZEBRAFISH. Kyoshiro Tsuge , Ryosuke Wakabayashi, Satoru Yamamoto, Chika Koishihara, Akira Shimamoto 2487-Pos Board B237 THE ROLE OF CARDIAC CAPILLARY ENDOTHELIAL CELLS IN ELECTRO METABOLIC SIGNALING AND BLOOD FLOW REGULATION. Guiling Zhao, Schuyler Brown, W. J. Lederer 2488-Pos Board B238 EUGENOL RESCUES THE TRPV1-DEPENDENT INHIBITION OF KCNQ2/3. Juan Jose Romero-Tovar, Alejandro Rafael Medina-Vilchis, Adrian Rivera-Ruedas, Victor De la Rosa 2489-Pos Board B239 ROLE OF MITOCHONDRIAL PKA IN COMPARTMENTATION OF CAMP SIGNALING IN CARDIAC VENTRICULAR MYOCYTES. Rinzhin Tshering Sherpa , Karni S. Moshal, Shailesh R. Agarwal, Robert D. Harvey 2490-Pos Board B240 REGULATION OF CARDIAC MYOCYTE CYCLIC AMP PRODUCTION BY INTRACELLULAR Α 1 -ADRENERGIC RECEPTORS. Chase M. Fiore , Michael Rudokus, Rinzhin Tshering Sherpa, Karni S. Moshal, Shailesh R. Agarwal, Robert D. Harvey 2491-Pos Board B241 KIR SIGNALING IS REGULATED BY ELECTROSTATIC INTERACTION OF ITS CYTOSOLIC TAIL WITH THE PLASMA MEMBRANE DESPITE BEING NEU TRAL POLYAMPHOLYTE. Santosh Kumar

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