Biophysical Society 67th Annual Meeting Program Guide

2518-Pos Board B268 PROTEIN KINASE A (PKA) ACTIVATION REORGANIZES MICROTUBULES AND MICROTUBULE-PLUS-END-BINDING-PROTEIN 1 (EB1) AND ENRICHES NAV1.5 AT THE INTERCALATED DISCS (ICDS) OF ADULT VENTRICULAR MYOCYTES. Gea-Ny Tseng 2519-Pos Board B269 THE OPEN STRUCTURE OF A NEONATAL DIABETES-CAUSING VARIANT OF THE PANCREATIC K ATP CHANNEL DETERMINED USING CRYO-ELECTRON MICROSCOPY. Camden M. Driggers , Show-Ling Shyng 2520-Pos Board B270 THE LEUCINE ZIPPER EF-HAND CONTAINING TRANSMEMBRANE PRO TEIN-1 EF-HAND IS AN ATYPICAL TRIPARTITE CALCIUM, TEMPERATURE, AND PH SENSOR. QiTong Lin , Peter B. Stathopulos 854-Plat Board B271 A SMALL MOLECULE INHIBITOR OF SUMO PREVENTS THE HYPOXIA-IN DUCED DECREASE IN IK1 CURRENT. Aishwarya Chandrashekar , Kirin Gada, Yu Xu, Yuchen Yang, Leigh D. Plant 2522-Pos Board B272 LOSS OF VISION CAUSED BY AN ALKALINE SHIFT IN THE P H-DEPENDENCE OF THE CORNEAL H + /OH - -CONDUCTING MEMBRANE PROTEIN SL C4A11. Bianca N. Quade, Aniko Marshall, Mark D. Parker 2523-Pos Board B273 STUDYING PROTEIN VARIATION IN EVOLUTION, DISEASE, AND BIOLOGY THROUGH DEEP INSERTION, DELETION, AND MISSENSE MUTATIONAL SCANNING. Christian B. Macdonald 2524-Pos Board B274 RE-ASSESSING THE ROLE OF THE HELIX BUNDLE CROSSING IN NAK. Vilius Kurauskas , Marco Tonelli, Katherine A. Henzler-Wildman 2525-Pos Board B275 PERTURBATION OF HCN1 RESPONSE TO SMALL MOLECULE MODULA TION. Elizabeth D. Kim , Maria E. Falzone, Gareth R. Tibbs, Matthew Ferrer, Peter A. Goldstein, Crina M. Nimigean 2526-Pos Board B276 ESTABLISHING THE ROLE OF THE MITOCHONDRIAL VOLTAGE-DEPENDENT ANION CHANNEL (VDAC), IN TRYPANOSOMA CRUZI . Sebastian Mesones Mancilla , Kyle Poon, Veronica Jimenez 2527-Pos Board B277 DIFFERENTIAL MODULATION OF ALPHA 7 NICOTINIC ACHRS BY PICO MOLAR VS HIGH NANOMOLAR OR MICROMOLAR CONCENTRATIONS OF AMYLOID BETA 42 PEPTIDE. Joseph Farley , Jonathan B. Anderson 2528-Pos Board B278 AB INITIO MD FOR K+ CHANNEL PARAMETER OPTIMIZATION. Chenggong Hui , Wojciech Kopec, Bert L. de Groot 2529-Pos Board B279 ELEMENTARY MECHANISMS UNDERLYING ACTIVATION OF LEAK SODIUM CHANNELS. Allen L. Hsu , Nourdine Chakouri, Manu Ben-Johny 2530-Pos Board B280 LIPID DEPENDENCE OF BSYETJ CALCIUM TRANSPORT ACTIVITY BY FLUO RESCENCE AND ESR TECHNIQUES. Yu-Jing Lan , Yun-Wei Chiang 2531-Pos Board B281 ANALYSIS OF CATION PERMEATION MECHANISM OF CHR2 BY MOLECULAR DYNAMICS SIMULATION. Kenta Shobu , Yoshinori Hirano, Hiroshi Wata nabe, Kenji Yasuoka 2532-Pos Board B282 VISUALIZING ION CHANNELS IN LIPID NANODOMAINS USING LIVE-CELL FLUORESCENCE LIFETIME IMAGING. Gucan (Gabriel) Dai

2533-Pos Board B283 REDUCTION OF SK CURRENT IN RAT CPVT MODEL WITH HETEROZY GOUS CALMODULIN 3 MUTATION D132E IS CAUSED BY IMPAIRED IN TRACELLULAR CA2+ HOMEOSTASIS. Roland Veress , Benjamin Y. Martin, Shanna Hamilton, Vladimir Bogdanov, Radmila Terentyeva, Fruzsina Perger, AndrewM. Soltisz, Svetlana Tikunova, Rengasayee Veeraragha van, Sandor Gyorke, Jonathan P. Davis, Dmitry A. Terentyev 2534-Pos Board B284 Travel Award Winner MOLECULAR ORIGIN OF THE PROTON SELECTIVITY IN THE HUMAN VOLTAGE-GATED PROTON CHANNEL. Grace Liu , Chenghan Li, Gregory A. Voth 2535-Pos Board B285 FUNCTIONAL CHARACTERIZATION OF A METAL ION COORDINATION SITE IN HCN4. Lucas M. Blecker , Colin H. Peters, Diego A. Peraza, John Bankston, Cathy Proenza 2536-Pos Board B286 VOLTAGE-SENSOR TRAPPING IN HV1 CHANNEL ( CI H V 1). Miguel Fernández , Juan J. Alvear-Arias, Emerson M. Carmona, Antonio Peña Pichicoi, Christian A. Carrillo-Soto, Jose A. Garate, Carlos Gonzalez 2537-Pos Board B287 ENERGETIC DESTABILIZATION OF SHUT STATES UNDERPINS THE MEMBRANE STRETCH DEPENDENT ACTIVATION OF PIEZO1. Tharaka D. Wijerathne , Alper D. Ozkan, Jerome J. Lacroix 2538-Pos Board B288 UNCOVERING INDIVIDUAL PROTONATION EVENTS IN KIR2 CHAN NELS. Michael Bründl-Jirout , Grigory Maksaev, Sun Joo Lee, Anna Stary Weinzinger, Eva-Maria Plessl, Colin G. Nichols 2539-Pos Board B289 POTENTIATION OF CNG CHANNEL GATING BY MATRIX METALLOPRO TEINASES IS GOVERNED BY THE TURRET REGION AND INTRACELLULAR DISULFIDE BONDS. Sophie I. Biencourt , Peter Meighan, Kemal Donlic, Michael D. Varnum Other Channels (Boards B290 - B311) 2540-Pos Board B290 SMALL MOLECULE DISCOVERY FOR MODULATION OF OTOPETRIN PRO TON CHANNELS. Batuujin Burendei , Joshua Kaplan, Stefano Forli, Emily R. Liman, Andrew B. Ward 2541-Pos Board B291 THE HUMAN ERYTROCYTE MECHANO-ACTIVATED K + CHANNEL A (HEM KCA): EFFECT OF INTERACTION OF INTRACELLULAR CALCIUM AND PH ON CONDUCTION AND KINETICS VARIABLES. A PARTIAL STUDY. Michelle Cuccillo, Jesus G. Romero 2542-Pos Board B292 ANALYZING SMALL MOLECULE AND POLYMER EVENTS IN A PRO TEIN NANOPORE FOR PAIRED OPTICAL AND ELECTRICAL MEASURE MENTS. Sophie C. Anderson , Hannah M. Burden, Lisa Burden, Daniel L. Burden 2543-Pos Board B293 A NOVEL ACTIVATOR OF PIEZO1: WOUND HEALING ASSAY. Ajan Ahmed , Olajuwon Sally, Chilman Bae 2544-Pos Board B294 A SINGLE HIGH INTENSITY NANOSECOND ELECTRIC PULSE STIMULATES NALCN AND TRPC4/5 CHANNELS LEADING TO NA + ACCUMULATION IN ADRENAL CHROMAFFIN CELLS AS DETECTED BY LIVE CELL NA + FLUORES CENCE IMAGING. Lisha Yang , Gale L. Craviso, Normand Leblanc

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