Biophysical Society 67th Annual Meeting Program Guide

Ignacio Sanchez Burgos, University of Cambridge 319 -Pos, Board B140

Efthymios Kyriakis, University of British Columbia 104 -Plat STRUCTURAL INSIGHTS FOR THE MODULATION OF KCNQ1 CHANNEL BY ML277 Kerry V. Lane, University of California, Santa Barbara 116 -Plat DUAL-PROTEIN PATTERNING TO INVESTIGATE EFFECTS OF CELL-CELL ADHESIONS ON HIPSC-CM MATURITY Hannah McArthur, King’s College London 68 -Plat UNDERSTANDING HOW ANTIGEN MOBILITY AND ADHESION

CONDENSATE’S AGEING MODELLED THROUGH MOLECULAR DYNAMICS: PROTEIN STRUCTURAL TRANSITIONS CRITICALLY TRANSFORM THE NETWORK CONNECTIVITY AND VISCOELASTICITY OF RNA-BINDING PROTEIN CONDENSATES Adriana N. Santiago Ruiz, University of Pennsylvania 77 -Plat IN-SITU CHARACTERIZATION OF ALZHEIMER’S DISEASE TAU AGGREGATES VIA SUPER-RESOLUTION IMAGING Sajad A. Shiekh, Kent State University 365 -Pos, Board B186 IMPACT OF SHELTERIN COMPLEX ON TELOMERE ACCESSIBILITY Marton A. Simon, Semmelweis University 550 -Pos, Board B371 UNDERSTANDING IMPACT OF ΔF508 AND G551D CFTR MUTATIONS ON CFTR/PKA-C INTERACTION Rohit K. Singh, University of Colorado 59 -Plat DEFINING THE INTERACTIONS BETWEEN HCN4 AND THE REGULATORY PROTEINS IRAG AND LRMP Jenaro Soto, University of California, Irvine 201 -Pos, Board B22 DYNAMICS OF THE BYPASS POLYMERASE, DINB HOMOLOG Joseph C. Sudar, New York University Medical Center 202 -Pos, Board B23 UNDERSTANDING THE MOLECULAR COMPOSITION OF THE MICROSPORIDIAN POLAR TUBE Antonio Suma, SISSA 142 -Plat CHANNEL-LIPID INTERACTIONS DRIVE THE EMERGENCE OF ION CHANNEL CLUSTERING, CHANNEL-CHANNEL COOPERATIVITY, AND ACTIVATION HYSTERESIS Qian Tian, University of Massachusetts Amherst 451 -Pos, Board B272 VISUALIZATION OF MECHANICAL FORCES IN 3D CELL MODELS WITH MOLECULAR DNA TENSION PROBE Renata Torres da Costa, Rutgers University 473 -Pos, Board B294 DEPLETION OF MITOCHONDRIAL POLYP LEVELS INCREASE THE PHOSPHORYLATION OF AMPK PROTEIN AND COMPROMISES OXYGEN CONSUMPTION IN SH-SY5Y CELLS Chen-Wei Tsai, University of Colorado 168 -Plat MOLECULAR AND CELLULAR MECHANISMS UNDERLYING TISSUE SPECIFIC MICU-DIMER ASSEMBLY IN THE MITOCHONDRIAL CALCIUM UNIPORTER COMPLEX Wietske E. Tuinte, Medical University of Innsbruck 514 -Pos, Board B335 STAC PROTEINS INHIBIT THE VOLTAGE DEPENDENT INACTIVATION OF L-TYPE CALCIUM CHANNELS

MOLECULES INFLUENCE B CELL ACTIVATION Sarah Mersch, University of Minnesota Duluth 193 -Pos, Board B14

TIME-RESOLVED TWO-PHOTON FLUORESCENCE DYNAMICS OF A NOVEL MEGFP-LINKER-MSCARLET-I CROWDING BIOSENSOR Desmond Owusu Kwarteng, Kent State University 144 -Plat THE ELECTROSTATIC BASIS OF DIACYLGLYCEROL PYROPHOSPHATE

PROTEIN INTERACTION Marion Pierre, CERVO 492 -Pos, Board B313

CHARACTERIZATION OF ATRIAL FIBRILLATION LINKED MUTATIONS USING THE NA V 1 5 KNOCK-OUT OF ATRIAL CARDIOMYOCYTES DERIVED FROM IPSCS Tanadet Pipatpolkai, Science for Life Laboratory 141 -Plat PIP2 BINDING AT THE VOLTAGE SENSOR DOMAIN FACILITATES KCNQ1 VSD ACTIVATION AND GATING Nishadh Rathod, University of Alberta 164 -Plat COMPLEMENTARY IN VITRO FUNCTIONAL STUDIES AND IN SILICO ALCHEMICAL FREE ENERGY SIMULATIONS OF THE SARCO ENDOPLASMIC RETICULUM CALCIUM PUMP (SERCA) AND PHOSPHOLAMBAN (PLN) COMPLEX Tyler R. Reagle, University of Pennsylvania 393 -Pos, Board B214 INVESTIGATING THE MECHANOCHEMISTRY OF MEMBRANE AREA ASYMMETRY GENERATION: A COMBINED MASS-ACTION AND MICROMECHANICAL STUDY USING METHYL-BETA-CYCLODEXTRIN Aoon Rizvi, University of California, Irvine 333 -Pos, Board B154 REVEALING NANOSCALE STRUCTURE AND INTERFACES OF POLYMER AND PROTEIN CONDENSATES VIA CRYO-ELECTRON MICROSCOPY Kristy Rochon, Case Western Reserve University 204 -Pos, Board B25 CONFORMATIONAL CHANGES IN SOLUTION MULTIMERS OF DYNAMIN-RELATED PROTEIN 1 (DRP1) FACILITATES FUNCTIONAL ASSEMBLY Spencer J. Rothfuss, Vanderbilt University 287 -Pos, Board B108 THE ROLE OF K288A IN CONFORMATIONAL SELECTION IN LEUT

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