Biophysical Society 67th Annual Meeting Program Guide

Friday, February 17 Drug Discovery for Ion Channels XXIII Satellite Meeting 8:00 am - 4:35 pm, Room 8 Sponsored by Sophion Bioscience; Nanion Technologies; SB Drug Discovery; Metrion Biosciences; and Fluxion Ion channels are an important class of therapeutic drug targets, and mu tations in ion channel genes are found to be responsible for an increasing number of diseases. While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput. Because of this, ion channels remain an underrepresented target class for drug discovery. The advent of higher throughput automat ed electrophysiology systems has changed the face of ion channel drug discovery. Since the inaugural “Drug Discovery for Ion Channels” satellite meeting, there have been many advances in ion channel drug discovery including new instrumentation and techniques. This year’s meeting will highlight presentations from users of automated electrophysiology instrumentation as well as other speakers in the field of ion channel drug discovery, including several academic speakers. 8:00 AM REGISTRATION AND COFFEE 8:30 AM WELCOME AND OPENING REMARKS Daniel Sauter SESSION I Chair: Neils Fertig 8:45 AM Keynote Speaker MOLECULAR BASIS AND FUNCTION OF BK-CALCIUM SUBCELLULAR DOMAINS AS MODULATORS OF PLASTIITY IN THE BRAIN . Teresa Giraldez 9:30 AM PHARMACOLOGICAL CHAPERONES RESTORE THE TRAFFICKING AND FUNCTION OF PATHOGENIC GABAA RECEPTORS. Megan Yajuan 10:00 AM CHARACTERIZATION OF SMALL MOLECULE MODULATORS OF KNA CHAN NELS USING AUTOMATING PATCH CLAMP. Brittany Spitznagel 10:30 AM COFFEE BREAK SESSION II Chair: Ali Yehia 11:00 AM MOLECULARLY SELECTIVE NAV1.1 POTENTIATORS INCREASE PV+ FAST SPIKING INTERNEURON EXCITABILITY AND RESTORE MOTOR PERFOR MANCE IN A MOUSE MODEL OF DRAVET SYNDROME. Sam Goodchild 11:30 AM ANTAGONIZING NACHRS TO TREAT PAIN AND ADDICTION. Andrew Riley 12:00 PM STRUCTURAL AND FUNCTIONAL INVESTIGATION OF MECHANICAL COU PLING BETWEEN L-TYPE CALCIUM CHANNELS AND RYANODINE RECEP TORS . Philip Van Petegem


Chair: Daniel Sauter


1:30 PM ADVANCED PATCH CLAMP PROTOCOL DESIGNS TO REVEAL HIDDEN DE TAILS OF ION CHANNEL-DRUG INTERACTIONS. Péter Lukács 2:00 PM PERIPHERALLY-RESTRICTED GABA-A MODULATORS FOR THE TREATMENT OF IBS AND VISCERAL PAIN. Mike Poslusney 2:30 PM IN VIVO CONLN VIVO CONTROL OF SKELETAL MUSCLE CONTRACTION AND HEART RHYTHM USING PHOTOSENSITIVE CAGED NATURAL PEPTIDES. Michael DeWaard 3:00 PM COFFEE BREAK SESSION IV Chair: Robert Kirby 3:30 PM DEVELOPMENT OF NEW KV7.2/7.3 CHANNEL ACTIVATORS. Nina Ottoson 4:00 PM GAIN-OF-FUNCTION MUTATIONS IN NAV1.6 AND EPILEPTIC SEIZURES. Manoj Patel 4:30 PM CLOSING REMARKS Neils Fertig Exhibitor Registration 8:00 am - 5:00 pm, Lobby BC Registration 3:00 pm - 5:00 pm, Lobby BC New Council Orientation 3:30 pm - 4:30 pm, Hilton, Aqua Boardroom Joint Council Reception, Dinner, and Meeting 5:00 pm - 9:00 pm, Hilton, Aqua 310 Society of General Physiologists Meeting 6:00 pm - 9:00 pm, Room 14A


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