Biophysical Society 67th Annual Meeting Program Guide

Channels, Receptors, and Transporters Symposium 8:30 am - 12:30 pm, Room 6B

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10:10 am 10:30 am

panel discussion on map quality: single particle cryo-em validation - what to submit with your manuscript 10:40 am research talk from abhay kotecha, thermo fisher scientific: towards high-resolution and high-throughput structural biology with cryo-em No Abstract 10:55 am MOLECULAR ARCHITECTURE OF THE JUMBO BACTERIOPHAGE NUCLEAR SHELL. Elizabeth Villa 7-Subg 11:20 am RHOPTRY SECRETION SYSTEM STRUCTURES AND REGULATORY MECHA NISMS IN APICOMPLEXAN PARASITES REVEALED USING CRYO-ET. Shrawan Kumar Mageswaran, MatthewMartinez, Amandine Guérin, Wil liam Chen, Liam Theveny, Marta Cova, Petra Molnár, Audrey John, Boris Striepen, Maryse Lebrun, Yi-Wei Chang 11:45 am flash talks from selected abstracts 12:10 pm closing remarks 12:15 pm subgroup business meeting Membrane Fusion, Fission, and Traffic Symposium 8:30 am - 12:30 pm, Room 6D Subgroup Chair Phyllis Hanson, University of Michigan, USA No Abstract 8:30 am THE BIOPHYSICS OF BULKY CARGO EXPORT FROM THE ENDOPLASMIC RETICULUM. Morgan Chabanon, Ishier Raote, Nikhil Walani, Vivek Mal hotra, Maria F. Garcia-Parajo, Marino Arroyo, Felix Campelo 8-Subg 9:00 am USING QUANTITATIVE MICROSCOPY APPROACHES TO STUDY THE FOR MATION OF CLATHRIN-COATED VESICLES. Emanuele Cocucci , Comert Kural No Abstract 9:30 am EMERGING ROLES FOR SECRETORY AUTOPHAGY IN EV BIOGENESIS AND CARGO SPECIFICATION. Jayanta Debnath 10:00 am break No Abstract 10:30 am A NON-CANONICAL ROLE FOR A COPII SUBUNIT IN THE SELECTIVE DEG RADATION OF THE ER. Susan Ferro-Novick No Abstract 11:00 am INTERACTIONS BETWEEN INTRINSICALLY DISORDERED PROTEIN REGIONS AND CURVED MEMBRANE SURFACES. Wade F. Zeno 11:30 am sir bernard katz award: jose rizo-rey, university of texas southwestern medical center “ molecular mechanisms underlying calcium-triggered neurotransmitter release ” 12:15 pm announcements Nanoscale Approaches to Biology Symposium 8:30 am - 12:30 pm, Room 5AB Subgroup Chair Chan Cao, Ecole Polytechnique Federale de Lausanne, Switzerland 8:30 am opening remarks

S A T U R D A Y

Subgroup Chair Jorge E. Contreras, University of California Davis, USA 8:30 am opening remarks 5-Subg 8:35 am

HETEROMERIC LRRC8 CHANNEL ASSEMBLIES AND THEIR IMPACT ON CHANNEL ACTIVITY. Elena F. Lehmann , Sonja Rutz, Dawid Deneka, Antje Dittmann, Marta Sawicka, Raimund Dutzler No Abstract 9:05 am A TALE OF TWO PORES. Johanna Syrjanen No Abstract 9:35 am PHARMACOLOGY AND ACTIVATION MECHANISMS FOR LARGE-PORE PANNEXIN 1 CHANNELS: FROM A SINGLE-CHANNEL PERSPECTIVE. 10:05 am HYDROPHOBIC AND HYDROPHILIC RESIDUES IN AMINO TERMINAL DOMAIN OF CX46 AND CX50 ARE CRITICAL FOR THEIR GAP JUNCTION CHANNEL GATING AND THE RATE OF ION PERMEATION. Donglin Bai 10:35 am subgroup business meeting 6-Subg 11:00 am COMPUTATIONAL STUDIES OF MOLECULAR PERMEATION THROUGH LARGE-PORE CHANNELS. Yun Lyna Luo No Abstract 11:30 am NOVEL BIOPHYSICAL PROPERTIES IN LARGE-PORE CHANNELS. Yu-Hsin Chiu No Abstract

Pablo Gaete No Abstract

12:00 pm MOLECULAR PHYSIOLOGY OF CALHM ION CHANNELS. J. Kevin Foskett

Cryo-EM Symposium 8:30 am - 12:30 pm, Room 6F

Subgroup Chair Ariane Briegel, Leiden University, Netherlands Program Co-Chairs Henriette Autzen, University of Copenhagen, Denmark

Gabriel Lander, Scripps Research Institute, USA Cristina Santarossa, NYU Langone Health, USA Rosemary Cater, Columbia University, USA Meghna Gupta, University of California, San Francisco, USA 8:30 am opening remarks No Abstract 8:35 am ARCHITECTURE OF ERYTHROCYTE ANKYRIN-1 COMPLEXES. Oliver Clarke No Abstract 9:00 am MACHINE LEARNING FOR CRYO-EM RECONSTRUCTION. Ellen Zhong No Abstract 9:25 am HOW “NATIVE” IS YOUR PROTEIN? IMPACTS OF CRYO-EM SAMPLE PREPARATION ON PROTEIN STRUCTURE. Rebecca Thompson No Abstract 9:50 am UNTANGLING INTEGRIN DYNAMICS USING CRYO-EM. Melody Campbell No Abstract 10:00 am UNDERSTANDING ARCHITECTURE, ASSEMBLY, AND REGULATION OF BACTERIAL TOXIN DELIVERY SYSTEMS BY ELECTRON CRYOTOMOGRAPHY. Debnath Ghosal

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