Biophysical Society 67th Annual Meeting Program Guide

Platform Membrane Pumps, Transporters, and Exchangers 4:00 pm - 6:00 pm, Room 6F

145-plat 5:00 pm CALMODULIN EXTRACTS THE RAS FAMILY PROTEIN RALA FROM LIPID BI LAYERS BY ENGAGEMENT WITH TWO MEMBRANE-TARGETING MOTIFS. Andrea Gohlke , Samuel G. Chamberlain, Arooj Shafiq, Iolo J. Squires, Darerca Owen, Helen Mott 146-plat 5:15 pm ALLOSTERIC MODULATION OF THE INTEGRAL ENZYME OMPLA BY MEM BRANE ASYMMETRY. Enrico F. Semeraro , Paulina Piller, Sandro Keller, Georg Pabst 147-plat 5:30 pm PHASE SEPARATION CAN REGULATE MEMBRANE CURVATURE GENERA TION BY BAR-PROTEINS. Samsuzzoha Mondal , Karthik Narayan, Tobias 5:45 pm DIRECT INTERACTIONS BETWEEN PICORNAVIRUS 3CD PROTEIN AND PHOSPHOINOSITIDE LIPIDS IN VIRUS REPLICATION ORGANELLES. David D. Boehr , Dennis S. Winston, Jie Yu Platform Protein Dynamics and Allostery I 4:00 pm - 6:00 pm, Room 6E Co-Chairs Lauren Alexandrescu, University of Oxford, United Kingdom Ferran Feixas, University of Girona, Spain 4:00 pm TIME EVOLUTION OF THE SUBSTRATE-INDUCED MILLISECOND ALLO STERIC ACTIVATION OF IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE. Ferran Feixas 150-plat 4:15 pm DELINEATING THE CONFORMATIONAL LANDSCAPE OF CANNABINOID RECEPTOR 1 (CB1R) USING GAUSSIAN ACCELERATED MOLECULAR DY NAMICS AND NETWORK ANALYSIS. Peter Obi , Senthil Natesan 151-plat 4:30 pm DYNAMIC ALLOSTERIC NETWORKS DRIVE ADENOSINE A 1 RECEPTOR ACTIVATION AND G-PROTEIN COUPLING. Miguel A. Maria-Solano , Sun Choi 152-plat 4:45 pm ELECTROSTATIC NETWORKS FOR CHARACTERIZATION OF ALLOSTERIC PATHWAYS: ALLOSTERIC PATHS IN CAS9 APO, DNA- AND RNA-BOUND FORMS. Federica Maschietto , Gregory W. Kyro, Brandon Allen, Pablo R. Arantes, Giulia Palermo, George P. Lisi, Victor S. Batista 153-plat 5:00 pm Travel Award Winner LAWS: LOCAL ALIGNMENT OF WATER SITES - DESCRIBING ALLOSTERIC WATER NETWORKS IN ENZYMES. Eugene Klyshko , Justin S. Kim, Sarah 5:15 pm A CENTRAL HELICAL SWITCH CONTROLS INTEGRATED STRESS RESPONSE SIGNALING VIA EIF2B CONFORMATION AND ASSEMBLY. Rosalie Lawrence , Sophie Shoemaker, Aniliese Deal, Lan Wang, Susan Marqusee, Peter Walter 155-plat 5:30 pm INFLUENTIAL NODES DRIVE DYNAMIC ALLOSTERY IN PROTEIN TYROSINE PHOSPHATASES. Colin L. Welsh , Alexandr P. Kornev, Lalima K. Madan 156-plat 5:45 pm THE MOLECULAR BASIS OF PROTEOLYTIC INACTIVATION IN THE HUMAN LONP1 PROTEASE VIA LONG-TIMESCALE MOLECULAR DYNAMICS. Lauren A. Alexandrescu , Gabriel C. Lander, Philip C. Biggin Baumgart 148-plat 149-plat Rauscher 154-plat

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S U N D A Y

Co-Chairs Oliver Beckstein, Arizona State University, USA Hristina Zhekova, University of Calgary, Canada

157-plat 4:00 pm NECESSARY AND SUFFICIENT MOLECULAR DETERMINANTS OF QUA TERNARY AM MONIUM ANTISEPTIC EXPORT BY SMALL MULTIDRUG RESISTANCE TRANSPORTERS. Olive E. Burata , Victoria E. O’Donnell, Jeonghoon Hyun, Randy Stockbridge 158-plat 4:15 pm ELEVATOR TRANSPORT MECHANISM IN SLC4 TRANSPORTERS: INSIGHTS FROM NEW INWARD FACING CRYO-EM STRUCTURES OF AE1. Hristina R. Zhekova , Jiansen Jiang, Weiguang Wang, Kirill Tsirulnikov, Gülru Kayık, Hanif Muhammad Khan, Rustam Azimov, Natalia Abuladze, Liyo Kao, Debbie Newman, Sergei Y. Noskov, D. Peter Tieleman, Hong Zhou, Alex ander Pushkin, Ira Kurtz 159-plat 4:30 pm CONFORMATIONAL DYNAMICS AND PH-REGULATION IN APCT. Kelli N. Kazmier , Dungeng Peng, Brandy Verhalen, Jeanette Matthieu, Matthias Quick, Richard A. Stein, Hassane S. Mchaourab 160-plat 4:45 pm INSIGHTS INTO AUTOREGULATION OF A MEMBRANE PROTEIN COMPLEX BY ITS CYTOPLASMIC DOMAINS. Vanessa Leone , Lucy R. Forrest, Richard Bradshaw, Caroline Koshy, Paul S. Lee, Maria Cristina Fenollar-Ferrer, Veronika Heinz, Christine M. Ziegler 161-plat 5:00 pm THERMODYNAMICALLY CONSISTENT STOCHASTIC MODELS FOR ACTIVE TRANSMEMBRANE TRANSPORT PROCESSES. Oliver Beckstein , Ian M. Kenney, Nikolas Awtrey, Shujie Fan 1945-Pos 5:15 pm ELUCIDATING BACTERIAL LIPID TRANSPORT MECHANISMS BY THE ENVELOPE-SPANNING LETAB COMPLEX. Cristina C. Santarossa , Max Haase, Minkyung Baek, David Baker, Damian Ekiert, Gira Bhabha 163-plat 5:30 pm LIPID TRANSLOCATION IN THE OMEGA-3 FATTY-ACID TRANSPORTER MFSD2A. Louis Tung Faat Lai , Nguyen Chi, Hsiang-Ting Lei, Gallenito J. Marc, Xuelang Mu, Tamir Gonen, Doreen Matthies 164-plat 5:45 pm Travel Award Winner COMPLEMENTARY IN VITRO FUNCTIONAL STUDIES AND IN SILICO ALCHEMICAL FREE ENERGY SIMULATIONS OF THE SARCO-ENDOPLASMIC RETICULUM CALCIUM PUMP (SERCA) AND PHOSPHOLAMBAN (PLN) COMPLEX. Nishadh Rathod , Joseph O. Primeau, Christophe J. Chipot, Benoit Roux, Howard S. Young

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