Biophysical Society 67th Annual Meeting Program Guide

Dinner Meet-Ups 6:00 pm - 6:30 pm, Lobby BC/Society Booth

tration of bound protein, and stoichiometric information, in solution, and all in a single experiment, whether using simple biological buffer systems or complex backgrounds such as serum, plasma, saliva, and cell lysates. The MDS technology enables quantification and characteriza tion of any protein interaction – even in complex backgrounds or with challenging targets • Characterize membrane proteins • Track functional immune response in serum samples • Reveal therapeutic antibody / protein interaction mechanisms • Characterize disordered proteins, higher-order complexes, or amyloids under close to in vivo conditions • Explore aggregation effects and distinguish between specific and non specific binding During our presentation we will describe a series of case studies and collaborations with pioneering researchers covering such topics: • Purification-free affinity and concentration measurement of mem brane-protein targets • Determination of antibody affinities and concentrations directly in clinical samples • In-solution measurement of antibody affinities and binding stoichiom etries to neurotoxic amyloid species • Binding of Fc-engineered IgG antibodies to FcRn • In-solution affinity measurement of a drug-induced protein complex Speaker Molly Coseno, Sales Application Specialist, Fluidic Analytics Korean Biophysicists Meeting 5:00 pm - 5:30 pm, Room 7AB Exhibitor Presentation LUMICKS 5:30 pm - 7:00 pm, Room 9 From Dynamic Single-Molecule Data to Direct Quantitative Insights Into Biological Mechanisms The value of dynamic single-molecule research in providing direct insight into the molecular mechanisms of biology has been proven for many years. However, this realm of science has long been accessible only to experts that could build and operate complex instruments, had the knowledge to produce specific samples, and could develop sophisti cated methods for analyzing the data. The LUMICKS C-Trap enabled studying dynamic molecular mechanisms with a ready-to-go instrument. It uniquely correlates single-molecule force and fluorescence measurements to capture all molecular interac tions in real time. With the release of biochemistry products, scripting library, and sharing platform an ecosystem was initiated with the aim to provide researchers with all the tools to do their research. We are now taking the next big step in this by launching Lakeview data analysis: a software platform that enables any scientist to instantaneously analyze their science – from raw data to quantitative insights into mechanisms with a couple of clicks. In this talk we will present Lakeview and show how it can be used to organize, manage, and visualize all your dynamic single-molecule data on any laptop and PC. We will show how it enables automatic tracking of the location and dynamics of individual proteins on DNA and how that can be used to instantaneously visualize resulting data. From here you gain direct quantitative insights into biological mechanisms. And there is more to come! Speaker Trey Simpson, Application Scientist Manager, LUMICKS

F R I D A Y

Interested in making new acquaintances and experiencing the cuisine of San Diego? Meet at the Society Booth each evening Sunday through Tuesday at 6:00 pm, where a BPS member will coordinate dinner at a local restaurant. Student Research Achievement Award (SRAA) Poster Competition 6:00 pm - 9:00 pm, Exhibit Hall BC This session features graduate, masters and PhD students who are pre senting posters at the Annual Meeting and have indicated at the time of abstract submission that they wish to participate in the competition. During the competition, students will deliver a five-to-seven minute oral presentation of their poster to one or more judges. Winners will be recognized on Monday evening prior to the Biophysical Society Lecture. BPS Editors Dinner 7:00 pm - 10:00 pm, San Diego Wine and Culinary Center

S U N D A Y

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