Biophysical Society 67th Annual Meeting Program Guide

235-pos Board B56 ALLOSTERIC REGULATORY CONTROL IN DIHYDROFOLATE REDUCTASE (DHFR) REVEALED WITH DYNAMIC ASYMMETRY IN UNLIGANDED EN SEMBLE. I. Can (John) Kazan , Jeremy H. Mills, S. Banu Ozkan 236-pos Board B57 RNA-INDUCED ALLOSTERIC COUPLING DRIVES VIRAL CAPSID ASSEMBLY IN THE SINGLE-STRANDED RNA VIRUS BACTERIOPHAGE MS2. Sean Hamilton , Tushar Modi, Petr Sulc, S. Banu Ozkan 237-pos Board B58 DETERMINING THE MECHANISMS OF THE ALLOSTERIC ARCHITECTURE OF DHFR. James W. McCormick , Jerry C. Dinan, Marielle A. Russo, Kimberly A. Reynolds 238-pos Board B59 EXPERIMENTAL RECONSTRUCTION OF MEMBRANE TRANSPORTER EVO LUTION. Krishna Reddy , Olga Boudker 239-pos Board B60 REVEALING THE ALLOSTERIC MECHANISM OF PH-DEPENDENCE IN THE PROTON-ACTIVATED CHLORIDE CHANNEL. Ekaterina Kots , Harel Wein stein 240-pos Board B61 Travel Award Winner ARRESTIN C-TAIL DYNAMICS REGULATE ACTIVATION AND GPCR ENGAGE MENT. John Janetzko , Asuka Inoue, Yuqi Shi, Jonathan C. Deutsch, Korak Kumar Ray, Matthieu Masureel, Ruben L. Gonzalez, Rosa Viner, Brian K. Kobilka, Rabindra Shivnaraine 241-pos Board B62 PROBING GPCR ALLOSTERIC ACTIVATION AND BIASED SIGNALING WITH RIGIDITY PROPAGATION AND GEOMETRIC MONTE-CARLO SIMULA TIONS. Adnan Sljoka 242-pos Board B63 PRESSURE-BASED MAPPING OF ARF1 SWITCH TRANSITION. Tejaswi Naidu Koduru , Edgar Peters, Noam Hantman, Catherine A. Royer 243-pos Board B64 THE CONFORMATIONAL SPACE OF THE SARS-COV-2 MAIN PROTEASE ACTIVE SITE LOOPS IS DETERMINED BY LIGAND BINDING AND INTERPRO TOMER ALLOSTERY. Ethan Lee , Sarah Rauscher 244-pos Board B65 UNDERSTANDING BIRA ALLOSTERY FROM A NETWORK PERSPECTIVE US ING MD SIMULATIONS. Riya Samanta , Silvina Matysiak 245-pos Board B66 POSITIVE FEEDBACK IN RAS ACTIVATION THROUGH MODULATION OF SOS ACTIVATION PROBABILITY. He Ren , Albert Lee, Lap Jung Nugent Lew, Joseph B. DeGrandchamp, Jay T. Groves 246-pos Board B67 SINGLE-MOLECULE FLUORESCENCE: ELUCIDATING ATP DRIVEN PROTEIN TRANSPORT IN THE SEC COMPLEX. Joel A. Crossley , Tomas Fessl, Ian Col linson, Roman Tuma, Sheena E. Radford 247-pos Board B68 QUANTIFYING THE EVOLVABILITY OF ALLOSTERY AT DIFFERENT PROTEIN SURFACES. Jerry C. Dinan , Kimberly A. Reynolds 248-pos Board B69 IDENTIFICATION OF SUBSTRATE-SPECIFIC ALLOSTERIC FINGERPRINTS IN MATRIX METALLOPROTEASE-1 AT THE SINGLE MOLECULE LEVEL FOR PRECISION CONTROL OF FUNCTION. Susanta K. Sarkar 249-pos Board B70 CHARACTERIZATION OF IMMUNOGLOBULIN-Ε (IGE) TO BENEFIT THERA PEUTIC IGE ENGINEERING. Chinh Su

250-pos Board B71 SELECTIVE VIRTUAL SCREENING OF HYPOXIA INDUCIBLE FACTOR AGO NISTS AND ANTAGONISTS USING ARTIFICIAL INTELLIGENCE AND LINEAR RESPONSE THEORY. Rajat Punia , Gaurav Goel 251-pos Board B72 FROM ELUCIDATING MECHANISMS OF ALLOSTERIC SIGNALING TO DESIGNING ALLOSTERIC DRUGS AND BIOLOGICS. Wei-Ven Tee , Zhen Wah Tan, Enrico Guarnera, Igor N. Berezovsky Membrane Protein Structures I (Boards B73 - B93) 252-pos Board B73 STRUCTURE AND FUNCTION OF ABC TRANSPORTERS IN OCEANIC SPE CIES. Megan Young 253-pos Board B74 STRUCTURAL BASIS FOR PHAGE SINGLE GENE LYSIS PROTEIN MECHA NISMS. Yancheng E. Li , Anna K. Orta, WilliamM. Clemons Jr 254-pos Board B75 MULTIMERIC ASSEMBLY AND DYNAMICS OF PORE-FORMING LANTIBI OTIC PEPTIDE NISIN. Hugo A. Perez 255-pos Board B76 STRUCTURE OF THE SHAKER KV CHANNEL IN LOW K AND MECHANISM OF SLOW C-TYPE INACTIVATION. Xiaofeng Tan , Kenton Swartz 256-pos Board B77 PUTATIVE PORE STRUCTURE OF AMYLOID ΒΕΤΑ AND ALPHA SYNUCLEIN IN LIPID BILAYERS. Ankita Dutta 257-pos Board B78 CRYO-EM SNAPSHOTS AND PROTEIN SPIN LABELING IN STRUCTURAL STUDIES OF HIV-1 VPU. Md Majharul Islam , Oluwatosin Adetyui, Saman Majeed, Olamide Ishola, Isaac Forester, Steven J. Ludtke, Elka R. Geor gieva 258-pos Board B79 EXPLORING THE STRUCTURE AND FUNCTION OF THE PEPTIDASE-ABC TRANSPORTER FUSION PROTEIN ZMAM. Gerardo E. Zavala , Jose A. Vel illa, Mit Patel, Richard M. Walsh, Rachelle Gaudet 259-pos Board B80 INVESTIGATING THE MOLECULAR EVOLUTION OF SMALL MULTIDRUG RESISTANT TRANSPORTERS. Victoria E. O’Donnell , Olive E. Burata, Randy Stockbridge 260-pos Board B81 STRUCTURE REFINEMENT OF TRANSMEMBRANE DOMAIN OF KCNE3 IN PROTEOLIPOSOMES USING EPR SPECTROSCOPY. Indra D. Sahu , Matthew Scheyer, Conner Campbell, Patrick L. Williams, Isaac K. Asare, Afsana Begum, Mustakim Hussain, Charles R. Sanders, Gary A. Lorigan 261-pos Board B82 CRYO-EM STRUCTURES OF THE TOLQ MEMBRANE PROTEIN IN COMPLEX WITH INNER MEMBRANE PROTEIN PARTNER TOLR FROM THE OPPOR TUNISTIC PATHOGEN ACINETOBACTER BAUMANNII PROVIDE INFORMA TION ON STRUCTURE AND STOICHIOMETRY. Elina Karimullina , Yirui Guo, Bradley Quade, Rosa Di Leo, Zbyszek Otwinowski, Dominika Borek, Alexei Savchenko 262-pos Board B83 INTRINSIC FIDUCIALS FOR SMALL MEMBRANE PROTEIN STRUCTURE DETERMINATION. Michael P. Dalton , Jonathan Coleman

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