Biophysical Society Bulletin | December 2025

Publications

Know the Editor Robert Vandenberg University of Sydney

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Editor, Channels, Transporters, and Receptors Biophysical Journal

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Robert Vandenberg

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What are you currently working on that excites you? I am part of a really exciting collaboration with colleagues in the United States, Denmark, and Australia to develop glycine transport inhibitors for the treatment of neuropathic pain. It is a project where we are using the structure of the trans porter with various drugs bound to define what chemical modifications are possible to optimize the performance of the compounds in animal models of neuropathic pain. The project involves cryo-EM, medicinal chemistry, biophysical character ization of drug effects on the transporter, pharmacokinetics, and behavioral pharmacology. The compounds show partic ular promise and we are hopeful of taking the compounds to clinical trials in the next year or two. Who would you like to sit next to at a dinner party (scientist or not)? I am getting towards the end of my scientific career, which has prompted me to reflect on all the wonderful opportunities I have been privileged to have enjoyed. I would love to have dinner with the various scientists around the world who have made important contributions to the scientist, and person, that I am, so that I can thank them for all the small things they have done that are so important. This would include my postdoc supervisors, John Shine , Peter Schofield , and Susan Amara , as well as scientists that I have worked with such as Mike Kavanaugh , Chris Cioffi , Azadeh Shahsavar , Sarasa Moham madi , Megan O’Mara , and Tristan Rawling . I am so very grateful for their interest in me and my work, and I would like to thank them for fostering a passion for science and the joy of work ing together on projects that matter.

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Biophysical Reports Dual-view microscopy of single-molecule dipole orientations Yonglei Sun and Quan Wang “The transition dipole orientations of fluorescent molecules bound to target biomolecules give access to the target’s local structural information, and therefore can serve as unique probes in structural biology. This article proposes an alterna tive imaging geometry, referred to as ‘dual-view microscopy,’ for more efficient three-dimensional single-molecule dipole orientation measurements compared with existing schemes. The authors demonstrate using simulation that the scheme outperforms conventional epifluorescence microscopy in esti mation precision and can simultaneously measure absorption and emission dipole orientations independently. Dual-view microscopy represents a new paradigm that will further advance single-molecule orientation imaging as an emerging structural biology tool.”

Version of Record Published October 22, 2025 DOI: https:/doi.org/10.1016/j.bpr.2025.100234

Tell Me About Your Poster at BPS2026! Members of the Publications Committee and BPS Journal Editorial Boards will be viewing the posters throughout the Annual Meeting wearing buttons reading “Tell Me About Your Poster.” Introduce yourself and explain the research in your poster and you can receive a 10% discount on publication fees if your related article is accepted by a BPS Journal!

December 2025

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