Biophysical Society Bulletin | November 2018

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November 2018

T H E N E W S L E T T E R O F T H E B I O P H Y S I C A L S O C I E T Y

Society Names 2019 Fellows The Biophysical Society is proud to announce its 2019 Class of Fellows. The Fellows award is given to Society members who have demonstrated sustained excellence in science and have contributed to the expansion of the field of biophysics. The 2019 Fellows will be recognized at the awards ceremony on Monday evening, March 4, during the Society’s Annual Meeting in Baltimore, Maryland.

Marileen Dogterom , Delft University of Technology, The Netherlands, for her pi- oneering experimental work on elucidating the physical mechanisms that govern assembly and dynamics of cytoskeleton filaments, in particular microtubules.

Judith Frydman , Stanford University, USA, for her fundamental contribu- tions to deciphering the role of molecular chap- erones in protein folding, quality control, and cell regulation. Stefan Hell , Max Planck Institute for Biophysical Chemistry, Germany, for his pioneering develop- ment of stimulated emission depletion microscopy, radically overcoming the Abbe resolution limit and permitting to record fast movements within living cells. Zaida Luthey-Schulten , University of Illinois at Urbana-Champaign, USA, for the devel- opment of ribosomal dynamics and whole cell simulations, model- ling diffusion-reaction networks andmetabolic pathways within entire cells.

Gilad Haran , Weizmann Insti- tute of Science, Israel, for his outstanding contributions to the development and applications of single- molecule methods for studying folding of single- andmulti-domain proteins. Kenneth Johnson , University of Texas, Austin, USA, for his sustained contributions to biophysics and for his impactful studies using advanced enzyme kinetics in a wide variety of systems.

Judith Frydman

Gilad Haran

Marileen Dogterom

Inside Biophysicist in Profile

2 4 5 7 8

Publications From the Blog Public Affairs Annual Meeting Thematic Meeting

Stefan Hell*

Kenneth Johnson

16 Member Corner & Important Dates 17 Student Spotlight 17 Communities 18 Outreach 20 Career Development 22 Grants and Opportunities 23 Upcoming Events 24

Rohit Pappu , Washington University in St. Louis, USA, for ingeniously imple- menting polymer physics approaches andmolecular simulations to character- ize intrinsically disordered proteins.

Zaida Luthey-Schulten

Rohit Pappu

Start Your Planning! Join this global celebration of biophysics by planning an event in your local area. Last year there were over 65 affiliate events that took place all over the world during Biophysics Week. Let’s make this year’s celebration even bigger! Register your event with BPS by January 15, 2019, and receive a free customized poster to use at your event. To register your event, please go to: www.biophysics.org/biophysicsweek.

Biophysicist in Profile

Officers President Angela Gronenborn President-Elect David Piston Past-President Lukas Tamm Secretary Frances Separovic Treasurer Kalina Hristova Council

Heather Pinkett Areas of Research How organisms transport compounds across membranes

Lynmarie Thompson , University of Massachu- setts Amherst, worked with Pinkett in 2005 when she was on a sabbatical in Rees’s lab at Caltech. “I worked closely with Heather during my sabbatical; she taught me how to do crystallization trials on membrane proteins. I thoroughly enjoyed working with her be- cause of her infectious enthusiasm for science and her positive attitude. She also has great insights. In the Rees lab, I jokingly referred to her approach to membrane protein purifica- tion as ‘the Heather prep,’” she says. “She had recently come to the lab from a background in soluble proteins, and had immediate success in purifying and crystallizing an ABC transporter. Heather realized that for membrane proteins it is important to limit the length and number of purifica- tion steps to avoid stripping key lipids away from the protein.” Pinkett’s first presentation at a Biophys- ical Society Annual Meeting was in 2007 during her postdoc. “This exposure led to invitations to present at a Gordon Con- ference and to give talks at other insti- tutions during the first year in my faculty position,” she says. “These meetings have always provided a place for me to connect with the transport community. The talks are always amazing and often times the speakers at the meeting become my short list of who to invite for talks in my department seminar series, especially junior faculty. It is also a good place to spot potential faculty candidates. I treat the meetings like a retreat. I always come away invigorated and ready to tackle the next big problem.” After Caltech, she took a position as an asso- ciate professor in the Department of Molec- ular Biosciences at Northwestern University. “We are currently looking at how bacterial pathogens and fungals utilize the transport mechanism to survive within the host with a focus on resistance mechanisms. We study exporters (pump substrates out) and import- ers, as well as the transcriptional regulators that control expression of these transporters,” she explains. “While some ABC transporters only transport on substrate, others are quite promiscuous. Understanding how a particular transporter selects and transports a toxin, which in turn is targeted for degradation, is critical for the development of therapeutics.”

“There are so many interesting transporters that we as a field have yet to explore, and we are realizing that the diversity in ABC trans- porters is broader than we first thought,” she says. “While all use ATP binding and hydrolysis in the transport mechanism, we now see that there are mechanistic differences in selectiv- ity and regulation and we have yet to really scratch the surface in understanding how they work in concert to maintain homeostasis and circumvent toxins. Our lab is interested in the evolution and selectivity of substrates, and regulation these systems.”

Institution Northwestern University

At-a-Glance

Zev Bryant Jane Clarke Linda Columbus Bertrand Garcia-Moreno Teresa Giraldez Ruben Gonzalez, Jr. Arthur Palmer Marina Ramirez-Alvarado Jennifer Ross David Stokes Joanna Swain Pernilla Wittung-Stafeshede Biophysical Journal Jane Dyson Editor-in-Chief Society Office Ro Kampman Executive Officer Newsletter Executive Editor Rosalba Kampman Managing Editor Beth Staehle Contributing Writers and Proofreaders Dorothy Chaconas Laura Phelan

Heather Pinkett grew up around science, with a mother who worked as a nurse, and never hesitat- ed to pursue a life in science herself. After having the opportunity to participate in research as an undergraduate, she knew it was the right fit for her. She would encourage students to consider following in her footsteps to a fulfilling career: “The area of biophysics is diverse and provides so many opportunities to explore pressing questions about single molecules, the cell, and everything in between. I recently had a student tell me, ‘biochemistry was hard enough; should I pursue bio- physics research?’ So I would say, don’t be intimidated by the word. Start early and gain as much research experience as possible.”

Heather Pinkett

Heather Pinkett , associate professor in the Department of Molecular Biosciences at Northwestern University, and her sisters were always around science as they grew up. Their mother was a registered nurse and they had medical books around the house. “My mom was the one who would catch dose miscalculations on patients’ charts, so other nurses started double-checking with her. I think those stories really emphasized paying attention to detail,” Pinkett explains. She and her sisters all attended a math and science magnet high school, Manhattan Center for Science and Math in New York. Her older sister pursued biology for her undergraduate de- gree, and Pinkett followed her into science, studying chemis- try at Connecticut College. “As an undergraduate I started doing research in the laborato- ry of Professor David K Lewis , in the area of gas phase reaction kinetics. This led to an opportunity to do summer research as part of an National Sanitation Foundation-sponsored Research Experience for Undergraduates in Chemistry,” she shares. “I enjoyed collaborating with such a talented group of students and PIs all with a common goal of answering a single question using many different approaches.” As a post-baccalaureate researcher, she was part of the Pre-Intramural Research Training Award program at the National Human Genome Research Institute (NHGRI), an institute of the National Institutes of Health. Through this program, she had the opportunity to work as part of a group investigating prostate cancer, spending full days doing exper- iments, analyzing the results with the head of the research team, and then hearing the research group present those results to the larger collaborative team. “It was an amazing opportunity for me to grow as a researcher,” she says. “When it was time for graduate school, I was ready to dive in and explore a new path, which was biophysics.”

Pinkett joined the Department of Biochemistry and Molecular Biophysics at the University of Pennsylvania School of Medi- cine, with a goal of studying structural biology. “From looking at genes and mutations, I wanted a deeper understanding of protein structure and function, especially as it relates to how mutations impact function,” she explains. “ John Carpten was a postdoc at NHGRI at the time and I remember having this conversation with him about the human genome project and what comes next.” When she was in graduate school, her department offered a seminar series called George Raiziss Biochemical Rounds, in which students read articles ahead of time, attended talks, and had an opportunity to go to dinner with the speakers afterward. “I always found the talks — especially on trans- porters and channels — extremely interesting and would make sure I signed up first to go to the dinners. When it was time for me to look for a postdoc position, I focused on labs looking at structure and function of membrane proteins,” Pinkett says. She took a postdoctoral position in the lab of Douglas Rees at the California Institute of Technology (Caltech), where she worked on the structure and function of ATP-binding cassette (ABC) transporters. “As a postdoctoral fellow, I solved the structure of an ABC transporter in an inward facing confor- mation, providing the first picture of an ABC transporter in its final conformational state,” she shares. “ABC transporters harvest the energy of ATP hydrolysis to transport a wide range of molecules across membranes. Three-dimensional images of each step in the transport process are critical to understanding the molecular mechanism, but are difficult to obtain because ABC transporters are membrane proteins and challenging targets for structure determination.”

Pinkett and her husband Adam Held celebrate daughter Piper’s third birthday.

Austin Rice , one of Pinkett’s first graduate students, worked with her for five years and co-authored four papers with her concerning the mechanism of ABC transporters. “Heather is an incredibly driven and meticulous scien- tist. She is persistently optimistic,” he says. “No matter how challenging a project looked, she could see all the great possibilities in it. And when things got tough, she was very good at finding alternative paths to answer key questions.” Pinkett finds challenges exciting, and funda- mental to the broad range of research that falls into the category of biophysics. “As a field, we are always evolving and embracing new approaches to get at the complexity of biological systems. I am always open to using physics-based methods to study biologi- cal systems,” she says. “We can look at our favorite macromolecules on the molecular level to understand mechanism, then expand our focus to study networks and interactions on the cellular level, all under the umbrella of biophysics.”

Dorian Russell Caitlin Simpson Elizabeth Vuong Sean Winkler Production

Ray Wolfe Catie Curry

The Biophysical Society Newsletter (ISSN 0006-3495) is published eleven times per year, January-December, by the Biophysical Society, 5515 Security Lane, Suite 1110, Rockville, Maryland 20852. Distributed to USA members and other countries at no cost. Canadian GST No. 898477062. Postmaster: Send address changes to Biophysical Society, 5515 Security Lane, Suite 1110, Rockville, MD 20852. Copyright © 2018 by the Biophysical Society. Printed in the United States of America. All rights reserved.

November 2018

T H E N E W S L E T T E R O F T H E B I O P H Y S I C A L S O C I E T Y

Publications

Open Access in Biophysical Journal As with many journals, papers in Biophysical Journal (BJ) are not freely available until 12 months after publication. This policy protects the journals’ subscriptions. For the Biophysical Society, subscription income is vital to the royalty payment that the Society receives from Cell Press, and constitutes a significant portion of the Society’s revenue (27% of Society income). This historic “reader pays” model of restricted access to publications has been challenged as elitist and contrary to the spirit of the global scientific enterprise. Indeed, several funding agencies demand that manuscripts resulting from their grants to investigators be published as open access (OA), that is, no embargo on free access. Govern- ment funding agencies in several countries are also insisting that papers from their citizen scientists are published in open access journals. As a result, most journals now provide an alternative model for sharing papers, which is the hybrid open access mod- el. For publication as OA, authors might pay a flat fee that includes page charges, figures, and open access; alternatively, authors might pay an open access fee in addition to page charges and or other publications costs such as color charges. For Biophysical Journal , authors who want their papers to have open access now pay $1,800(US) in addition to page and color charges. For reference, an average 10-page article with OA now costs an author $2450. Currently, about 10 percent of all BJ authors select OA, but due to requirements from outside agencies, we expect this percentage to increase. The Biophysical Society opted to move from publishing BJ independently to publishing it under the Cell Press aegis in 2009. The Society has benefited from Cell Press associa- tion through its larger global presence and publicity, as well as lower publication costs. The Society maintains complete control of the editorial content and editorial process, and its editors are all appointed by BPS. Revenues from BJ accrue to our Society. This background is important to appreciate the new open access structure that will affect BJ on 1 January, 2019: BJ will increase open access fees to $2,500, with a commensurate reduction in page charges of up to $700 for these articles. Will all journals become exclusively open access? Most scien- tific publishers say that is the future (see next article). There are financial consequences for any journal moving toward this model. The most obvious is the loss of subscription revenue. Although access to Biophysical Journal is a benefit of BPS membership, libraries and institutions are major subscribers

Know the Editor Tom Perkins

to the Journal. This 2019 increase in open access fees is a responsible move in preparing for this inevitable shift to open access at some point in the future. When you decide where to publish, please consider that Bio- physical Journal is our Society journal. It is not for profit. It will only flourish if you support it with your papers. — Kathleen B. Hall , Chair of Publications Committee Plan S – The Push for Open Access by 2020 On September 4, 2018, 11 European national research fund- ing organizations announced the launch of “Plan S,” an initia- tive that stipulates “scientific publications that result from research funded by public grants provided by participating national and European research councils and funding bodies, must be published in compliant open access journals or on compliant open access platforms.” The target date is January 1, 2020, for this initiative to take effect. Publishers and open access supporters met with staff at the Office of Science and Technology Policy recently as the Trump Administration is considering changes to the federal open access policy for publicly funded research. According to the 10 principles of Plan S, the hybrid model of publishing is not compliant with the Plan. This will impact Biophysical Journal as well as many other society and com- mercial journals. While publishers ponder the implications of Plan S, one of the immediate impacts will be that researchers will be severely restricted in where they can submit their work for publication (one estimate is over 85% of existing journals). Among the other principles outlined by Coalition S are two that have raised a lot of questions and eyebrows: • When open access fees are applied, their funding is stan- dardized and capped (across Europe) [Note, the amount of the cap has yet to be determined]. • The funders will ensure jointly the establishment of ro- bust criteria and requirements for the services that com- pliant high-quality open access journals and open access platforms must provide [no word on how far this will go with funders dictating publishing practices to journals]. The full list of 10 principles is available at https:/www.scien- ceeurope.org/coalition-s/. One proposal that has been put forward in response to the capping of open access fees (also called article processing charges or APCs) is to institute submission fees. APCs apply only to accepted/published manuscripts, which pay for the evaluation of all other submitted manuscripts, accepted or not. APCs for hybrid journals will only increase without off- setting subscription fees. Submission fees, applied across all

manuscripts shifts the model to where one is paying for peer review, bringing “peer review in line with lots of other services that cost money regardless of whether you succeed or fail, such as professional exams...” Of course submission fees would be unpopular with authors, and other proposals are sure to surface. In the meantime, publishers are looking for ways to publish high-quality jour- nals without charging excessive APCs. In Search of…Content In the realm of scholarly publishing, only about 45% of people use searching to find articles; 55% of the time articles are found via related articles, emails, alerts, and other non-search discovery techniques, according to a recent report by Renew Publishing Consultants How Readers Discover Content in Schol- arly Publications: Trends in Reader Behavior from 2005 to 2018. In this large-scale survey of 10,977 readers of scholarly pub- lications, when asked “When you need to do a search for arti- cles on a specific subject, where on the web do you start that search?” the leading answer was a bibliographic database (abstracting or indexing service, such as Pub Med), followed by an academic search engine, such as Google scholar or Mic- rosoft Academic Search. The third most popular method was a general search engine (e.g., Google). While abstracting and indexing services are a primary dis- covery source for the academic and medical sectors, aca- demic researchers rate academic search engines as the most important discovery resource when searching for journal articles. Only the academic sector uses Google Scholar more than Google. In China, Google Scholar is the dominant search engine for finding journal articles, although Baidu is growing in popularity. To learn more, see the full report at http:/ renewpublishing- consultants.com/wp-content/uploads/2018/08/How-Read- ers-Discover-Content-2018-Published-180903.pdf From the Blog CRISPR: Facts, Myths, and How to Engage the Public BPS member Kelsey Bettridge, Johns Hopkins Universi- ty School of Medicine, writes about the public dialogue surrounding CRISPR and offers advice on how to talk to non-scientists about the facts and misconceptions about the technology. https:/www.biophysics.org/blog/ crispr-facts-myths-and-how-to-engage-the-public biophysics.org/blog

University of Colorado, Boulder Editor, Molecular Machines, Motors and Nanoscale Biophysics

Tom Perkins

What are you currently working on that excites you? I am excited about the diversity of new scientific projects our lab is pursuing, ranging from model globular proteins and RNA pseudoknots to membrane proteins and human beta cardiac myosin. This diversity is enabled by a series of recent improvements in atomic-force-microscopy (AFM) based force spectroscopy (e.g., force stability, temporal resolution, and efficient, site-specific anchoring of biomolecules to coverslips and AFM tips). These improvements allow for a broader range of systems to be studied by AFM and do so more rapidly and with higher precision. The exciting intellectual challenge is to determine the biophysically interesting questions to ask in these diverse areas of force spectroscopy and then try to provide a nuanced presentation of our results to each com- munity. What has been your biggest “aha” moment in science? My biggest “aha” moment was when I was a graduate student in Steve Chu ’s lab. The scientific question was: Do entangled polymers exhibit a special tube-like motion called reptation, as proposed by Pierre de Gennes? Some polymer physicists loved the idea; others thought it was nonsense. In the early 1990s, a few groups were just starting to succeed at visualizing the dynamics of individual DNA molecules in an optical microscope via fluorescence. The conundrum vis-à-vis reptation was how to visualize one DNA molecule entangled in a mesh of other identical but unstained DNA molecules. Then came the “aha” moment. I was reading the original paper detailing YOYO, a newly developed dye for staining DNA. Most of the paper described YOYO’s synthesis and pho- tophysical properties. To me, the key sentence stated that when YOYO-stained DNA was mixed with unstained DNA, the YOYO molecules didn’t dissociate, but rather stayed bound to the original molecule. We now had the key reagent, and my labmate Doug Smith and I went on to experimentally confirm the fundamental assumption of reptation. To this day, our success reminds me of the importance of reading the details in the primary literature.

November 2018

T H E N E W S L E T T E R O F T H E B I O P H Y S I C A L S O C I E T Y

Publications

Public Affairs

Biophysical Journal Poster AwardWinners Congratulations to the winners of the Biophysical Journal Outstanding Poster Awards given at the meeting The Heart by Numbers: Integrating Theory, Computation and Experiment to Ad- vance Cardiology held September 4–7, 2018, in Berlin, Germa- ny. The poster winners were selected by a committee made up of top biophysicists including organizers of the meeting and editors of Biophysical Journal . The winners were recognized at the close of the meeting and received a certificate recognizing their achievement and a monetary prize.

Funding Increase for NIH Approved; NSF Left Flat On September 13, House and Senate negotiators approved a conference committee report and advanced a “minibus” fund- ing package, which included appropriations for the National Institutes of Health (NIH). In the package, NIH is set to receive a $2 billion funding increase compared to Fiscal Year 2018 levels. However, the package also included a short-term Continuing Resolution (CR), which provided flat, continued funding to keep federal agencies from shuttering on September 30. Unfortu- nately, the National Science Foundation (NSF) fell under the CR and any increase in funding will have to wait until the lame duck session begins, after the midterm elections. This is partic- ularly unfortunate as both House and Senate appropriators had proposed funding increases for the agency.

and passed the package by a 361–61 vote on September 26. On September 28, President Trump signed the package into law, averting a potential government shutdown on September 30. The House is now expected to be in recess through the mid- term elections. The Senate is likely to remain in session, period- ically, to consider various nominations for executive and judicial positions. The Society would like to thank our members for taking action over the last month in support of the NIH funding increase. BPS members generated over 225 messages to Congress in support of the package.

Winners of the Biophysical Journal Outstanding Poster Awards, from left, Meruyert Kudai- bergenova, Chon Lik Lei, Ilse van Herck, and Caroline Mendonca Costa. Meruyert Kudaibergenova University of Calgary, Canada State-Dependent Block of the HERG K+ Channel by Ivabradine: Allosteric Coupling to Drug Lipophilic Access Ilse van Herck Simula Research Laboratory, Norway In Silico Model of SK Channel Gating, Temperature Dependence and Calcium Sensitivity

The postdoctoral fellow poster winner and poster title are:

Caroline Mendonca Costa Kings College London, United Kingdom

Investigating the Role of Left Ventricular Lead Location in Arrhythmogenic Risk in Infarct Patients Undergoing Cardiac Resynchronization Therapy The student winners and posters titles are: Chon Lok Lei University of Oxford, United Kingdom Rapid Characterisation of HERG Kinetics Using Optimised Protocols on a High-Throughput System

On September 18, the Senate advanced this package by a re- sounding 93–7 bipartisan vote. The House quickly followed suit

British Scientists Fret a “No Deal” Brexit Scientists in the United Kingdom (UK) are raising alarms over the impacts to the research community of a “no deal” Brexit. Scientists for the EU, a campaign group started by British sci- entists, released a report in late August on the British govern- ment’s latest technical notes on Brexit stating the UK will no longer be eligible for three of the European Union’s (EU) major research funding programs. Their analysis states that up to 45 percent of EU research funding to the UK would be lost in a “no deal” Brexit. The British government maintains that it hopes to avoid leav- ing the EU without a deal, and is working hard to ensure that the UK maintains access to EU-supported research projects. The British government must put a deal in place with the EU by March 29, 2019, or risk a hard Brexit.

Golden Goose Awards Highlight Federally Supported Research

The Golden Goose Award was established in 2012 and officially recognizes scientists whose federally funded basic research has led to in- novations or inventions that have a significant impact on humanity or society. The Biophysical Society is an annual sponsor of the event. The awardees and the funding source for their research are:

The Biophysical Society series is pleased to present the completely revised second edition of Physics of Cancer by Claudia Mierke. Featuring updated, new content and figures to make this the must-have two-volume set of books on the topic.

BiophysicalSocietyseries Physics of Cancer Interplay between tumor biology, inflammation and cell mechanics

BiophysicalSocietyseries Physics of Cancer Cellular and microenvironmental effects

ClaudiaTanjaMierke

VOLUME ONE

SECOND EDITION

VOLUME TWO

SECOND EDITION

BiophysicalSociety

Chickens, Cells and Cytokines Stanley Cohen Funded by NIH Implicit Bias, Explicit Science Mahzarin Banaji , Anthony Greenwald , and Brian Nosek Funded by NIH and NSF

The Goose Gland: Discoveries in Immunology Bruce Glick (posthumously) Funded by NIH, NSF, and US Department of Agriculture

Author: Claudia Mierke Expected publication: September 2018

Download the first chapter of each volume for free at iopscience.org/books

November 2018

T H E N E W S L E T T E R O F T H E B I O P H Y S I C A L S O C I E T Y

Annual Meeting

Theory and Experiment to the Cell and Back

the “Call for Topics” email sent in August. As a general guide- line, 70–80 percent of the symposia are directly related to the research interests of the members as determined from the number of abstract submissions in past years. The remaining 20–30 percent represent emerging topics or areas not usually represented at the Annual Meeting. Workshops are where members learn about new tools and technologies that can transform their research. Workshops differ from symposia in that they are technique oriented, but are similar in that they are given by recognized leaders to an audience of non-specialists. Workshops cover emerging experimental and computational methods to provide partic- ipants with a working knowledge of the new technologies.

Workshops are held on Tuesday evening to avoid overlap with the other scientific sessions — so if you are planning a lab reunion or happy hour — plan to be back at the convention center in time for the workshops at 7:30 PM. Finally, don’t forget to look closely at the program book to learn about the many other events sponsored by the Soci- ety. These include programs focused on career development, funding opportunities, science policy, and more. Saturday Subgroup symposia are a meeting highlight open to all regis- tered meeting attendees, and be sure to attend the reception and dance. You will meet new people, and maybe even see your advisor dance (but be careful, you can’t “un-see” some things). Have fun at the meeting!

Navigating Your Way Through The Annual Meeting! — E. Michael Ostap

Thank you to our sponsors: Asylum Research Alvéole Beckman Coulter Life Sciences Bruker Corporation Carl Zeiss Microscopy LLC Cell Press Chroma Technology Hamamatsu Corporation Journal of Cell Science Journal of General Physiology Leica Microsystems LUMICKS Mad City Labs Molecular Devices Nanion Technologies Photonics Media Physics Today Sophion Bioscience A/S Wyatt Technology Corporation

Platform talks are opportunities for trainees and established scientists to give short oral presentations of highly signif- icant and novel work. Platform talks are not meant to be comprehensive reviews of the field, but rather are highly focused, short research presentations that are directed to those that work in the field. These presentations are given by both trainees and established investigators to audiences that range in numbers of 100 to 500. Abstracts from attendees who have requested to give a talk are distrib- uted to Council and Program Committee members with appropriate expertise, and the committee members make recom- mendations regarding appropriateness for oral presentation based on scientific impact. Efforts are taken to ensure the speakers within each platform session re- flect the diversity of the Society member- ship. If a research area receives very few abstract submissions, it is not eligible for its own platform session. In these cases, the Program Committee works to com- bine related abstract categories to create a platform session that can accommodate these oral presentations. You might be surprised to learn that approximately 30 percent of submitted abstracts are select- ed for an oral presentation. Symposia provide an in-depth exploration of an exciting topic of interest to attend- ees. Symposia talks are given by recog- nized leaders in their field who are given time to provide sufficient background to allow non-specialists to better under- stand their exciting research. Symposia are where meeting attendees can learn and be inspired by a field outside of their own. Many symposia topics are proposed by the Society membership in response to

The Biophysical Soci- ety’s Annual Meeting is an exciting, stimulating, and scientifically diverse forum for scientists at all career levels to meet, inform, and learn from their colleagues — and importantly — to dis- cover new and emerging fields in biophysics.

Career Events From putting potential students in touch with top biophysics programs, to assisting job seekers with resume critiques, to providing networking opportunities for mid-career professionals, this year’s Annual Meeting will feature a wide variety of ca- reer-enriching events for attendees at every career level.

E. Michael Ostap

Career Transitions Education & Career Opportunities Fair Sunday, March 3, 1:00 PM–3:00 PM

Industry Panel Monday, March 4, 1:00 PM–2:30 PM

There are poster sessions, platform talks, symposia, and workshops to attend — with some running concurrently. Because there is so much going on, the Annual Meeting can be overwhelming if one is not prepared! Here is a summary of the major meeting events to help you in your plan- ning. Also included is information about how the topics and speakers are selected. Poster sessions are the beating-heart of the meeting. These highly interactive sessions provide opportunities for all attendees, from the newest trainees to well-seasoned scientists, to present their work and get valuable one-on-one feed- back. Attendees can ask probing ques- tions about the unpublished work being presented and about recently published studies that relate to the poster. Poster sessions are a fantastic opportunity to meet new investigators, chat-up scientific heroes, and catch-up with old friends. Importantly, PIs and trainees also can explore potential mentorship opportuni- ties. Posters are grouped together based on topics of interest. These groupings are determined by historic trends of submit- ted abstracts and evolve over time via input from the Society’s Program Com- mittee. There are more than 700 posters presented each day — so be prepared!

Interested in pursuing a career in industry? Stop by to hear from a panel of experts who work in bio-related industries. Panelists will discuss how to find, select, and apply for in- dustry internships, providing attendees with useful tools and resources. Postdoc to Faculty Q&A: This question-and-answer luncheon is designed for postdocs finishing and actively applying for academic faculty posi- tions. Discussion will be led by a panel of new faculty in basic science and/or medical school departments and experienced faculty who have served as department chairs and/or part of faculty search committees. Topics for discussion include how to prepare the curriculum vitae, the interview process, networking, how to negotiate the job offer, and advice for new faculty as they balance research with their department obligations. To reserve a box lunch, you must pre-register. Attendance is limited to the first 60 participants. Registration is available on the Annual Meeting website. Transitions Forum and Lucheon Tuesday, March 5, 12:00 PM–2:00 PM

Are you looking to learn more about biophysics programs or looking for a career change? If so, then you must visit the Ed- ucation & Career Opportunities Fair. The Fair (formerly known as the Graduate and Postdoc Fair) has been expanded to include participation from institutions, agencies, and compa- nies. You will have the opportunity to visit schools represent- ing their programs, officers at agencies providing information on career opportunities, and companies looking for the right candidate to fill their open positions. Make connections and learn about different biophysics programs or career opportu- nities. This is one event that you won’t want to miss. TheWorld Outside the Lab: ManyWays to Use Your PhD Skills Sunday, March 3, 1:00 PM–2:30 PM Have you ever wondered how you can apply the skills learned while working on your PhD in a career away from the bench? This panel will explore multiple career options that exist in government, industry, and academia. Panelists with science backgrounds, now involved in a wide variety of careers, will share their personal experiences.

The BPS Annual Meeting has so many different opportunities for personal development, as well as career workshops, and networking events, specifically formulated for students to meet peers and discuss issues, ask questions, and make their own mark on the Society. — Vidhya Sivakumaran

biophysics.org/ 2019meeting

November 2018

T H E N E W S L E T T E R O F T H E B I O P H Y S I C A L S O C I E T Y

Annual Meeting

BPSCareer Center Schedule Career development workshops and resume critiques will be available in the Career Center fromSaturday, March 2 through Tuesday, March 5. AndrewGreen and Alaina Levine will lead workshops throughout the meeting and will also provide career counseling sessions. Registration is required for the limited number of one-on-one career counseling sessions. Please sign up for these appoint- ments onsite at the meeting beginning Saturday afternoon, March 2. These signups are on a first-come, first-served basis, one session per person. Please come prepared to your appoint- ment with resumes, CVs, and any other appropriate materials. Registration is not required for the workshops, but please show up on time! Saturday, March 2 3:00 PM–4:00 PM Leveraging LinkedIn in the PhD Job One-on-One Resume and Career Counseling: 1:00 PM–2:40 PM | 4:30 PM–5:30 PM Sunday, March 3 9:00 AM–10:00 AM Networking for Nerds: How to Create Your Dream Career ( Alaina Levine ) 10:30 AM–11:30 AM Green Cards for Scientific Search I: Understanding the Search Process from the Perspective of Search Committees and Decoding Job Announcements ( Andrew Green ) 2:30 PM–3:30 PM The Industry Interview: What you need to do before, during, and after to get the job ( Alaina Levine ) 4:00 PM–5:00 PM Nailing the Job Talk, or Erudition Ain’t Enough ( Andrew Green ) One-on-One Resume and Career Counseling: 8:30 AM–1:00 PM | 2:30 PM–6:00 PM Search: Networking, Informational Interviews, and more ( Andrew Green ) Researchers: How to win your EB- 1A/NIW Case! with Getson & Schatz, PC ( Brian Getson ) 12:00 PM–1:00 PM Demystifying the Academic Job

Professional Development Biophysics between the Lines: Creating Quantitative Resources for Biology Courses (RCN-UBE Pilot Program) Saturday, March 2, 9:00 AM–12:00 PM The Biophysical Society is working on a Building Bridges Research Consortium Project to develop a network of life scientists who will generate integrative learning modules that help incorporate more biophysical concepts into undergradu- ate biology education. This session will explore teaching ap- proaches that address key biological questions with a strong focus on quantitative methods. Teaching Science LikeWe Do Science Sunday, March 3, 2:00 PM–3:30 PM This interactive, hands-on workshop will provide participants with practical tools and evidence-based recommendations for bringing biophysics education to life in the lab, the classroom, and the community. Experienced educators will share their first-hand experiences in brief presentations. The session focus will be on collaborative group discussions, during which participants will design an individualized action plan for implementing active learning techniques and effective as- sessment strategies into their teaching practice. Moderators will offer guidance and advice on adequate projects for any educational level. Founding, Establishing, andMaintaining a Research Laboratory at Primarily This session is aimed at helping PUI faculty find funding for establishing or maintaining an active and productive under- graduate research laboratory. Networking Postdoctoral Breakfast Sunday, March 3, 7:30 AM–8:30 AM Postdocs, come and join your peers to meet and discuss the issues you face in your current career stage. The discussion will also include a moderated panel focused on work-life bal- ance and early career development. Limited to the first 100 attendees. Undergraduate Institutions Tuesday, March 5, 12:00 PM–1:30 PM

PI to PI, aWine & CheeseMixer Sunday, March 3, 5:00 PM–7:00 PM

You finally have a job working in biophysics, in industry or academia, with some funding and a lab, but you’ve realized that the career challenges continue. Come relax and network with your biophysics colleagues over a beer or glass of wine. This event is a great chance to compare notes with colleagues and discuss one-on-one your unique solutions to issues that arise in the time between getting your job and getting your next promotion, including management of lab staff, getting your work published in highly ranked journals, renewing your funding, and getting nominated for awards. BPS Student Chapter Organizational Meeting Monday, March 4, 11:00 AM–12:30 PM BPS Student Chapter members from around the world are invited to attend this exclusive event that will include effec- tive marketing and recruitment strategies, best practices in community outreach activities, and examples of successful chapter event organization. The event will convene BPS Student Chapter leadership and members in presentations, roundtable discussions, and planning for future student chap- ter activities at BPS Annual Meetings. Please RSVP for this event by contacting Programs Coordinator Dorian Russell at Career development and networking is important in science, but can be a big time commitment. This session offers the chance to speed network, an exciting way to connect with a large number of biophysicists (including Biophysical Society committee members) in a short amount of time. Mid-career and more experienced scientists could learn how to get more involved in the Society or network for open positions in their labs. Early career scientists could discuss career goals and challenges, get advice on tenure or grant writing, or find out how to gain recognition for their work. Graduate students and postdocs could make contacts to find their next position. By the end of the event, each participant will have had meaning- ful interactions with over half a dozen colleagues and the op- portunity to meet many more. It’s that simple! Refreshments will be served.Space is limited for this event and pre-registra- tion is recommended. Registration is available on the Annual Meeting website. drussell@biophysics.org. Speed Networking Monday, March 4, 2:30 PM–4:00 PM

Attendees browse available positions in the BPS Career Center.

Monday, March 4 10:00 AM–11:00 AM Demystifying the Academic Job Search II: Preparing your Written Application Materials: CV, Cover Letter, and Research Statement ( Andrew Green ) 11:30 AM–12:30 PM Networking for Nerds: How to Create Your Dream Career ( Alaina Levine ) 2:30 PM–3:30 PM The Strategic Postdoc: How to Find & Leverage your Postdoc Experience ( Andrew Green ) 4:00 PM–5:00 PM Developing Your 30-Second Value Statement (aka Your Elevator Pitch) ( Alaina Levine ) One-on-One Resume and Career Counseling: 8:30 AM–10:00 AM | 11:30 AM–12:30 PM | 2:00 PM–5:20 PM Tuesday, March 5 9:30 AM–10:30 AM Looking Beyond Academia: Identifying Your Career Options using MyIDP, LinkedIn & More ( Andrew Green ) 11:30 AM–12:30 PM The Industry Interview: What you need to do before, during, and after to get the job ( Alaina Levine ) 2:30 PM–3:30 PM Nailing the Job Talk, or Erudition Ain’t Enough ( Andrew Green ) One-on-One Resume and Career Counseling: 8:00 AM–9:00 AM | 9:00 AM–12:00 PM | 1:30 PM–5:00 PM

November 2018

T H E N E W S L E T T E R O F T H E B I O P H Y S I C A L S O C I E T Y

Annual Meeting

Subgroup Saturday Annual Meeting Symposia The Society’s 15 subgroups will hold symposia and business meetings on Saturday, March 2, 2019, in Baltimore, Maryland. For complete session information for each subgroup visit www.biophysics.org/2019meeting. Bioenergetics, Mitochondria, and Metabolism Subgroup Co-Chairs: Elizabeth Jones , Yale University, USA, and George Porter , University of Rochester, USA Speakers: William A. Cramer , Purdue University, USA Introduction: A New View of Organelle Energy Transduction: Super-Complexes Werner Kühlbrandt , Max Planck Institute for Biophysics, Germany Bioengineering Subgroup Chair: Amir Farnoud , Ohio University Speakers: Ka Yee Lee , University of Chicago, USA Susan Daniel , Cornell University, USA Golgi-on-a-Chip for the Cell-free Bio-nanomanufacturing of Pro- tein Therapeutics Jennifer Elisseeff , Johns Hopkins University, USA Immunoengineering in Regenerative Medicine Daniel Hammer , University of Pennsylvania, USA Upstream Migration of Amoeboid Cells: Dynamics and Memory Mark Uline , University of South Carolina, USA Utilizing the Synergistic Power of Molecular Theory and Molecular Simulation to Solve Bioengineering Problems Biological Fluorescence Subgroup Chair: Paul Wiseman , McGill University, Canada Speakers:

Lucy Shapiro , Stanford University, USA A Bacterial Membraneless Organelle Sequesters a Signaling Path- way that Drives Spatial Regulation of Cell Function Mark Leake , York University, United Kingdom Illuminating the Black Box of DNA-Protein Interactions Shana Elbaum-Garfinkle , City University of New York, USA Protein Phase Separation and Emergent Material Properties Kenwyn C. Huang , Stanford University, USA Conformational Dynamics of a Bacterial Actin Filament Predict in vivo Filament Length Danny Hatters , University of Melbourne, Australia Proteome Aggregation Patterns under Proteostasis Stress as Signatures for Understanding Huntington’s Disease Cell Biophysics Subgroup Chair: Jie Xiao , Johns Hopkins University School of Medicine, USA Speakers: Haw Yang, Princeton University, USA Unsupervised Statistical Learning of the Structural and Kinetic Elements in Multi-Resolution Dynamics Kandice Tanner , National Institutes of Health, USA High Frequency Active Microrheology Reveals Mismatch in 3D Tumor Intracellular and Extracellular Matrix Viscoelasticity Liedewij Laan , Delft University of Technology, The Netherlands Evolutionary Self-organization: Lessons from the Yeast Polariza- tion Machinery Christine Payne , Duke University, USA TiO2 Nanoparticle-cell Interactions: Importance of Protein Corona Johan Elf , Uppsala University, Sweden Genome-wide Single-cell Biophysics Jung-chi Liao , Academia Sinica IAMS, Taiwan Centriole Interaction Infrastructure Revealed by Superresolution Microscopy David Rueda , Imperial College School of Medicine, United Kingdom Imaging Cellular RNAs at Single Molecule Resolution with Fluor- genic RNA-Mango Aptamers Cryo-EM Subgroup Chair: Jenny Hinshaw , National Institutes of Health, USA Speakers: Alberto Bartesaghi , Duke University, USA Streamlining Workflows for Structure Determination by Single- Particle Cryo-ET Sub-Volume Averaging

Tim Grant , Howard Hughes Medical Institute, Janelia Campus, USA New Developments in the cisTEM Software Package Scott Stagg , Florida State University, USA Throughput and Resolution with a Next Generation Direct Detec- tor Alex Noble , New York Structural Biology Center, USA Cryo-tomography Methods and Spotition Thomas Marlovits , Center for Structural Systems Biology, Hamburg, Germany StarMap: Rosetta Refinement controlled from Chimera X Julia Mahamid , European Molecular Biology Laboratory, Germany Molecular Views into Cellular Function by In situ Cryo-Electron Tomography Exocytosis & Endocytosis Subgroup Chair: Amy Lee , University of Iowa, USA Speakers: Ira Milosevic , European Neuroscience Institute, University Medical Center Göttingen, Germany Regulation of Vesicle Acidification at the Neuronal Synapse Ed Chapman , University of Wisconsin, USA Contrasting the Functions of Synaptagmins 1 and 17 Nils Brose , Max Planck Institute of Experimental Medicine, Germany Synaptic Vesicle Priming and the Unique Features of Regulated Exocytosis at Nerve Cell Synapses Justin Taraska , National Institutes of Health, USA Imaging the Nanoscale Structure of Endocytosis and Exocytosis with Light and Electron Microscopy Intrinsically Disordered Proteins Subgroup Chair: Tanja Mittag , St. Jude Children’s Research Hospital, USA Jean Baum , Rutgers University, USA Modulating Alpha-synuclein Aggregation through IDP-IDP Interac- tions Jeetain Mittal , Lehigh University, USA Identifying Sequence-determinants of Protein Liquid-Liquid Phase Wolfgang Peti , University of Arizona, USA IDPs Enable Substrate Specificity of Protein Phosphatases Gary Pielak , University of North Carolina, Chapel Hill, USA Tardigrade Proteins and Desiccation Tolerance Joan-Emma Shea , University of California- Santa Barbara, USA Self-Assembly of the Tau Protein: Fibril Formation and Complex Coacervation

Cryo EM of Mitochondrial Super-Complexes William Dowhan , University of Texas Health Science Center, USA A Requirement for Cardiolipin in the Organization and Function of Mitochondrial Super-complexes Rosemary Stuart , Marquette University, USA Rcf1 and Rcf2: Central Role in Cytochrome c Oxidase Enzymology and Support of the Proton Motive Force Robert Gennis , University of Illinois, USA Structure of the Alternative Complex III from Flavobacterium John- soniae within a Supercomplex with Cytochrome aa3 Helmut Kirchhoff , Washington State University, USA Quinone Diffusion in Photosynthetic Membranes: Challenges Caused by Complex Membrane Architectures Carl E. Stafstrom , Johns Hopkins University, USA Ketogenic Diet: Evidence for Metabolic Control of Neuronal Excit- ability and Seizures Peter A. Crawford , University of Minnesota, USA Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Sig- naling, and Therapeutics Daniel P. Kelly , University of Pennsylvania, USA Ketone Bodies as a Therapeutic Strategy for Heart Failure Kieran Clarke , University of Oxford, United Kingdom Novel Ketone Monoester for Human Exercise and Cognition: Why, How, and When Eric Verdin , Buck Institute for Research on Aging, USA Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice Elena N. Dedkova , University of California - Davis, USA Ketone Bodies and their Polymers in Heart Failure and Type 2 Diabetes: Lessons Learned from the Ketone Ester Diet

Alessandra Cambi , Radboud University, The Netherlands Multimodal Microscopy Reveals Stiffness-dependent Nanoscale Remodeling of Different Actin Modules during Cell Protrusion Ralf Jungmann , Max Planck Institute of Biochemistry, Martinsried, Germany Superresolution Microscopy with DNA Molecules: Towards Local- izomics Luke Lavis , Janelia Research Campus, USA Building Brighter Fluorophores for Advanced Biological Imaging Bin Wu , Johns Hopkins University, USA Visualizing Translation Dynamics of Single mRNAs in Live Cells Don Lamb , Ludwig Maximilian University of Munich, Germany The Coming of Age: Fluorescence Investigations of the Early Child- hood of HIV Particles Elizabeth Hillman , Columbia University, USA High-speed, 3D, In Vivo Fluorescence Microscopy Biopolymers in Vivo Subgroup Chair: Simon Ebbinghaus , Technische Universität Braunschweig, Germany Speakers: James Bruce , University of Washington, USA Exploring the In Vivo Interactome

November 2018

T H E N E W S L E T T E R O F T H E B I O P H Y S I C A L S O C I E T Y

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