Biophysical Society Bulletin | November 2025

Annual Meeting

Sabrina Leslie , The University of British Columbia, Canada Single-Particle and Single-Cell Microscopy Advance the Bio physical Characterization, Understanding, and Optimization of Next-Generation Genomic Medicine Shixin Liu , The Rockefeller University, USA Visualizing Mammalian Transcription Elongation on DNA and Chromatin Peng Zheng , Nanjing University, China Computational Design of Ultrastable Protein via Hydrogen Bond Maximization for Extreme Environment Theory & Computation Subgroup Chair: Sarah Harris , University of Leeds, United Kingdom Speakers Sirish Kaushik Lakkaraju , Bristol Myers Squibb, USA MDFit: Using Machine-Learning to Predict Ligand Potency from Molecular Simulations

Alexander Pak, Institute of Science and Technology Austria, Austria Strategies to Perturb Protein Assemblies from a Coarse-Grained Molecular Dynamics Perspective Karissa Sanbonmatsu, Los Alamos National Laboratory, USA Multiscale Simulations at Biological Timescales: Simulating tRNA Dissociation from the Ribosome with MUON Postdoc Award Talk: Sergio Cruz-Leon, Max-Planck-Gesellschaft, Germany Bridging in Situ CryoET and Multi-Scale Simulations for Biological Discovery Early Career Award Talk: Rafael Bernardi, Auburn University, USA Where Biology Meets Chemistry: Harnessing Computation to Reveal Life’s Strongest Bonds Mid-Career Award Talk: Margaret Johnson, Johns Hopkins University, USA Timing and Decision Making through Macromolecular Self-Assembly

BPS2026 IUPAB Lecturer

The IUPAB-sponsored invited speaker at BPS2026 will be Sigrid Milles , Junior Group Leader at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. She will be speaking about “Intrinsically disordered regulators of endocytosis – an integrated NMR/single molecule fluorescence approach” at the 2026 Biophysical

Society Annual Meeting in San Francisco in February. Milles was trained as a biophysicist at Humboldt-Uni versität zu Berlin, after which she started a PhD in single molecule fluorescence spectroscopy at the European Molecular Biology Laboratory in Heidelberg, Germany. During this time, she studied the molecular mechanism of transport through the nuclear pore complex, focusing on the intrinsically disordered proteins that fill the inside of the pore. This interest in intrinsically disordered proteins brought her to the Institute de Biologie Structurale in Grenoble, France, as a postdoc, where she studied intrinsically disordered regions of the measles virus replication machinery by nuclear magnetic resonance (NMR) spectroscopy. She was recruited as a researcher by the French National Centre for Scientific Research in 2017 and has led an independent, European Research Council–funded team since 2019. In 2022, she moved to FMP in Berlin, where she leads the Junior group “Integrated Structural Dynamics.” Milles’ group combines single-molecule fluorescence and NMR spectroscopy to understand the molecular working mechanisms of intrinsically disordered proteins across time- and length-scales. Biologically, the group focuses on the intrinsically disordered regions that regulate endocytosis and thus control a central uptake mecha nism of the eukaryotic cell that is important for cellular organization and communication in health and disease. Sigrid Milles

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November 2025

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