Biophysical Society Conference | Tahoe 2022

Molecular Biophysics of Membranes

Wednesday Speaker Abstracts

STRUCTURE AND FUNCTION OF THE OTOP PROTON CHANNELS Emily Liman University of Southern California, USA No Abstract

STRUCTURAL DETERMINANTS OF SUBSTRATE SPECIFICITY IN SMALL MULTIDRUG RESISTANCE TRANSPORTERS Randy Stockbridge ; 1 University of Michigan, Molecular, Cellular, and Developmental Biology, Ann Arbor, MI, USA By providing broad resistance to ubiquitous disinfectants and antiseptics and other environmental biocides, transporters from the small multidrug resistance (SMR) family drive the spread of multidrug resistance cassettes among bacterial populations. A fundamental understanding of substrate selectivity by SMR transporters is needed to identify the types of selective pressures that contribute to this process. This talk addresses the molecular basis for the recognition of diverse substrates by two representative SMR proteins with different substrate specificities, revealed through a combination of x-ray crystallography and electrophysiological approaches.

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