Biophysical Society Conference | Tahoe 2022

Molecular Biophysics of Membranes

Poster Abstracts

43-POS Board 11 ENTROPIC STUDY OF THE EFFECT OF MEMBRANE FLUCTUATIONS IN PROTEIN OSCILLATION AND AGGREGATION Preet Sharma ; 1 Midwestern State University, Department of Chemistry & Physics, Wichita Falls, TX, USA Entropy is a fundamental property of any process, be it physical, chemical or biological. The study of entropy can reveal deeper understanding of systems which may not be possible using other methods. In this study we have used fluctuations in the membrane of proteins as they oscillate and aggregate. Since protein aggregation and even oscillation is considered to be a non- equilibrium process, we have used the dynamics of non-equilibrium physics to explain the entropy of a protein aggregation and oscillation. Fluctuations in the membrane of proteins contain vital information of how proteins behave. The information of physical dynamics such as protein oscillations and aggregation depend on the fluctuations in the membrane. The membranes can be of various structural identity. We have assumed a smooth protein membrane and applied fluctuations which are spontaneous in nature and might affect or even give rise to protein oscillations and other dynamics which happen in proteins. The fluctuations we have applied are mechanical in description and the proteins are model independent.

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