Biophysical Society Conference | Tahoe 2023

Proton Reactions: From Basic Science to Biomedical Applications

Daily Schedule

9:30 AM – 10:00 AM

Gebhard Schertler, Paul Scherer Institute and ETH Zurich, Switzerland The Role of Water Molecules in the Activation Mechanism of Retinal- Binding Membrane Proteins and G Protein-Coupled Receptors Paolo Carloni, Forschungszentrum Jülich, Germany Massively Parallel QM/M Simulations of Proton Transfer Processes in Different Environment

10:00 AM – 10:30 AM

10:30 AM – 10:50 AM

Coffee Break

Ballroom Pre-Function

Session XI

Protons in Cell Physiology and Disease Chair: Paolo Carloni, Forschungszentrum Jülich, Germany

10:50 AM – 11:00 AM

Bhav Kapur, Böhringer Ingelheim, Germany * Protons Taken Hostage

11:00 AM – 11:30 AM

Polina Lishko, University of California, Berkley, USA Protons in Reproduction, Contraception, and Heat Production Mark D. Parker, University of Buffalo, USA The Role of NH3 Promoting H+/OH- Flux Through the Alkali-Activated Channel Protein SLC4A11

11:30 AM – 12:00 PM

12:00 PM – 12:30 PM

Elena Pohl, University of Vienna, Austria Mitochondrial ATP/ADP Carrier - Proton or Fatty Acid Anion Transporter?

12:30 PM – 12:50 PM

Group Photo

12:50 PM – 2:00 PM

Lunch

Granhall/Garden Deck

Session XII

pH Sensing and Pharmacology Chair: Diana Barber, University of California, San Francisco, USA

2:00 PM – 2:30 PM

Dan Isom, University of Miami, USA Proton Gating of GPCR Signaling

2:30 PM – 3:00 PM

Christoph Stein, Charité Berlin, Germany Biophysics Meets Medicine: pH-Dependent Opioid Pain Killers

3:00 PM – 3:20 PM

Kota Katayama, Nagoya Institute of Technology, Japan (Young Investigator Talk) Photoactivation Mechanism of Cone Opsins Regulated by Proton Transfer Reaction

3:20 PM – 3:50 PM

Coffee Break

Ballroom Pre-Function

Session XIII

Gates and Protons Chair: Kota Katayama, Nagoya Institute of Technology, Japan Gustavo Chavez, KNMS, Paracelsus Medical University, Germany * Biophysical Properties of Newly Found Voltage-Gated Proton Channels Christophe Jardin, KNMS, Paracelsus Medical University, Germany * Learning About Properties of the Voltage-Gated Proton Channel From in Silico Methods

3:50 PM – 4:00 PM

4:00 PM – 4:10 PM

7