Biophysical Society Thematic Meeting - November 16-20, 2015

Biophysics in the Understanding, Diagnosis, and Treatment of Infectious Diseases Program

Session II

Chair: Edward Egelman, University of Virginia, USA

15:00 – 15:20

Stefan Barth, University of Cape Town, South Africa Use of Supercomputational Simulation of Dynamic Protein Interaction to Generate Knowledge-driven Targeted Fusion Proteins for Treatment of Infectious Diseases Constantinos Kurt Wibmer, National Institute for Communicable Diseases, South Africa* Structural Characterisation of an HIV-1 Broadly Neutralising Antibody Epitope in the gp120-gp41 Interface Stefan Raunser, Max Planck Institute of Molecular Physiology, Germany How to Kill a Mocking Bug—Structural Insights into Tc Toxin Complex Action Brian Baker, University of Notre Dame, USA* High Resolution, High Throughput Structural Modeling of T Cell Receptor Specificity and Cross-Reactivity: Implications for Immunotherapy

15:20 – 15:40

15:40 – 16:20

16:20 – 16:40

Coffee Break

16:40 – 17:10

Poster Session I

Old Wine Cellar

17:30 – 19:30

Tuesday, November 17, 2015

Registration/Information

Auditorium Foyer

8:00 – 17:00

Session III

Chair: James Sacchettini, Texas A&M University, USA

8:30 – 9:10

Tom Blundell, University of Cambridge, United Kingdom Biophysical Methods and Fragment-based Drug Discovery for Infectious Disease: Targeting Mycobacterium Tuberculosis and Mycobacterium Abscessus Robin Wood, Desmond Tutu HIV Centre (UCT), South Africa Novel Approaches to the Aerobiology of Tuberculosis Transmission Adam Yadon, Harvard University, and KwaZulu-Natal Research Institute for Tuberculosis and HIV, USA* Comprehensive Mutational Analysis of PncA SNPs Conferring in Vitro and in Vivo Pyrazinamide Resistance in M. Tuberculosis Valerie Mizrahi, University of Cape Town, South Africa Identifying Vulnerable Steps in the CoA Biosynthesis Pathway of M. Tuberculosis Robert Stroud, University of California San Francisco, USA Targeting the Membrane Proteome of mTB for Structure based Approaches to Function Coffee Break

9:10 – 9:50

9:50 – 10:10

10:10 – 10:40

10:40 – 11:20

11:20 – 12:00

12:00 – 12:20

Eric Galburt, Washington University School of Medicine, USA* Kinetic Regulation of Open Promoter Complexes by Mycobacterial Transcription Factors

*Short talks selected from among submitted abstracts

4