Biophysical Society Thematic Meeting| Padova 2019

Quantitative Aspects of Membrane Fusion and Fission

Thursday Speaker Abstracts

MOLECULAR SIMULATIONS OF PROTEIN-MEDIATED MEMBRANE REMODELING Herre Jelger Risselada 1 ; Laura Endter 1 ; 1 Georg-August University, Theoretical Physics, Goettingen, Niedersachsen, Germany Unlocking the molecular features on how molecules either accelerate or inhibit membrane remodeling both selectively and efficiently may help in generating novel therapeutic strategies. To this aim, we are developing state-of-the-art free energy calculation methods which can directly quantify how molecules alter molecular reaction pathways in conjunction with near- atomistic coarse-grained molecular simulations. We will illustrate a few examples on how free energy barriers challenge biological membrane remodeling processes and where proteins may come into play.

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