Biophysical Society Thematic Meeting| Padova 2019

Quantitative Aspects of Membrane Fusion and Fission

Poster Abstracts

56-POS Board 56 ROLE OF MEMBRANE MEDIATED FORCES IN RECEPTOR-MEDIATED ENDOCYTOSIS Jef Wagner 1 ; 1 Union College, Physics and Astronomy, Schenectady, New York, USA Many virus particles can gain entry to the cell through passive receptor mediated endocytosis, where the wrapping the the virus particle is driven through the binding of receptors embedded in the cell membrane with ligands on surface of the virus. The time it takes for the membrane to fully wrap a virus depends strongly on the diffusion rate of the receptors in the membrane, since new receptors must migrate to the wrapping site. This study uses a monte-carlo simulation to explore at how interactions between the receptors effect the time it takes for a virus to be fully wrapped.

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