Biophysical Society Thematic Meeting | Riga 2026

Active and Responsive Soft Matter: From Biological to Engineered Systems

Thursday Speaker Abstracts

DOES ONCOLOGY NEED THE PHYSICS OF CANCER? Josef Käs 1 ;

1 Leipzig University, Peter Debye Institute for Soft Matter Physics, Leipzig, Germany Cancer is a complex disease that accounts for nearly one in six deaths worldwide. More than 90% of deaths are due to metastasis. Despite advances in cancer treatment, metastatic recurrences remain a significant challenge. Understanding metastasis is crucial for a reliable predictive diagnosis needed for personalized oncology and to develop therapies that inhibit cancer spreading. The metastatic cascade roots in a mechanical problem for tumor cells on their way through the human body squeezing through dense tissues. Two clinical trials with more than 2000 breast cancer patients in each study prove that the onset of cancer cell motility can be explained as an unjamming transition and local cancer spreading of cancer cell clusters embedded in ECM can be described as active nematic droplets in a nematic phase. The gained physical parameters can be used prognostic tumor markers for metastatic risk that improves breast cancer diagnosis by 25%. Beyond diagnostics the mechanical modulation of cancer cells points us towards migrastatic therapies to suppress metastasis. Low dose paclitaxel treatment can induce cancer cell jamming and the crosstalk between adipose tissues and tumor cells can act as a cancer cell motility promoter or inhibitor.

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