Biophysical Society Thematic Meeting | Stockholm 2022

Physical and Quantitative Approaches to Overcome Antibiotic Resistance

Daily Schedule

Physical and Quantitative Approaches to Overcome Antibiotic Resistance Stockholm, Sweden August 14-18, 2022 All scientific sessions will be held at the Karolinska Institute, Biomedicum in the Eva & Georg Klein Lecture Hall unless otherwise noted. PROGRAM Sunday, August 14, 2022 17:00 – 19:30 Registration/Information Level 3, Exhibition Area 18:30 – 19:30 Welcome Reception Level 3, Exhibition Area

Monday, August 15, 2022 8:00 – 17:00

Registration/Information

Level 3, Exhibition Area

9:00 – 9:15

Joanna Slusky, University of Kansas, USA Welcome and Opening Remarks

Session I

Bacterial Membranes, Cell Walls, and Transport Joanna Slusky, University of Kansas, USA, Chair

9:15 – 9:45

Steven Boxer, Stanford University, USA * Protein Electric Fields Regulate Covalent Inhibition of Beta-Lactamases Mathias Winterhalter, Jacobs University, Germany Quantifying the Uptake of Antibiotics into Gram-Negative Bacteria

9:45 – 10:15

10:15 – 10:45

Coffee Break

Level 3, Exhibition Area

Session II

Bacterial Membranes, Cell Walls, and Transport (Continued) Joanna Slusky, University of Kansas, USA, Chair Megan O'Mara, The University of Queensland, Australia Are Polyunsaturated Lipids an Archilles’ Heel in Acinetobacter Baumannii Antimicrobial Resistance? Kaspar Locher, ETH Zürich, Switzerland Structural Basis of Drug Binding to Multidrug Transporters Revealed by Cryo Electron Microscopy Sergei Sukharev, University of Maryland, USA * Teasing Half-Bilayers: Physicochemical Properties of LPS Monolayers, Electrostatic Asymmetry of LPS-Phospholipid Bilayers and Implications for Drug/Peptide Permeability

10:45 – 11:15

11:15 – 11:45

11:45 – 12:00

12:00 – 13:00

Lunch

Level 3, Exhibition Area

Session III

Efflux and Drug Resistance Colin Kleanthous, University of Oxford, United Kingdom, Chair

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