Disordered Motifs and Domains in Cell Control - October 11-15, 2014

Tuesday, October 14, 2014 --------------------------------------------------------------------------------------------------------------------- 9:00 AM – 5:00 PM Registration/Information Gandon Central Session V: Dynamics within Protein Complexes and Roles in Regulation

Co-Chairs: Brenda Schulman, St. Jude Children’s Research Hospital, USA & Keith Dunker, Indiana University, USA Toby Gibson, European Molecular Biology Laboratory, Germany Regulation by In-complex Molecular Switching Abel Garcia-Pino, Vrije Universiteit Brussels, Belgium* Entropic Exclusion Determines Allostery in a Major Family of Intrinsically Disordered Bacterial Transcription Factors Jane Dyson, The Scripps Research Institute, USA Role of Functional Disorder in Large Protein Complexes Liesbeth Veenhoff, University of Groningen, The Netherlands Disordered Linker Regions for Sorting of Transmembrane Proteins Vincent Hilser, Johns Hopkins University, USA* Parallel Tuning of Activation and Repression in Intrinsic Disorder-Mediated Allostery Susan Taylor, University of California, San Diego, USA PKA: Dynamic Assembly of Macromolecular Signaling Complexes Lunch and Free Time Session VI: Motifs, Multi-Valency and Membrane-less Organelles in Cells Co-Chairs: Peter Tompa, Vlaams Institute of Biotechnology, Belgium & Peter Wright, The Scripps Research Institute, USA Dirk Görlich, Max Planck Institute for Biophysical Chemistry, Germany Nup98 FG-Domains from Diverse Species Spontaneously Phase- Separate into Hydrogels with Exquisite NPC-like Permeability Stephanie Weber, Princeton University, USA* Inverse Size Scaling of the Nucleolus by a Concentration- dependent Phase Transition Tanja Mittag, St. Jude Children’s Research Hospital, USA The Role of Multivalent Interactions of Tumor Suppressor SPOP with Gli3 in Regulating Ubiquitination Coffee Break Gandon South

9:00 – 9:30 AM

9:30 – 9:45 AM

9:45 – 10:15 AM

10:15 – 10:45 AM

10:45 – 11:15 AM

11:15 – 11:30 AM

11:30 AM – 12:00 PM

12:00 – 3:00 PM

3:00 – 3:30 PM

3:30 – 3:45 PM

3:45 – 4:15 PM

*Short talks selected from among submitted abstracts

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