Program Book

2434-P os B oard #B126 UNDERSTANDING THE EVOLUTION OF DYNAMICS FOR AN INTRINSICALLY DISORDERED PROTEIN. Daniel R. LaPorte , F. Marty Ytreberg 2435-P os B oard #B127 THE MECHANISM OF AMYLOID- β 42 FIBRIL ELONGA- TION. Thomas Gurry , Collin M. Stultz 2436-P os B oard #B128 DIFFERENCES IN DYNAMICS AND STABILITY OF THE WILD TYPE BETA-AMYLOID A β 1-40, AND ΔE22-A β 1-39 (JAPANESE) MUTANT PROTOFIBRIL STRUCTURES, A MOLECULAR DYNAMICS STUDY. Kipp W. Johnson , Tobin R. Sosnick, Karl F. Freed, Esmael J. Haddadian 2437-P os B oard #B129 MODELS OF LENGTH DEPENDENT BEHAVIOR IN POLYGLUTAMINE BASED ON IMPROVED SIMULATION METHODS. Natha R. Hayre 2438-P os B oard #B130 INFLUENCE OF DESOLVATION BARRIERS IN COUPLED FOLDING AND BINDING KINETICS OF PKID-KIX. Talant Ruzmetov, John J. Portman 2439-P os B oard #B131 DIFFERENT ROLES OF BACKBONE-ORIGINATED AND NATIVE-CONTACT-ORIGINATED FLEXIBILITIES OF AN INTRINSICALLY DISORDERED PROTEIN IN FAST BINDING AND UNBINDING. Koji Umezawa , Jun Ohnuki, Junichi Higo, Mitsunori Takano 2440-P os B oard #B132 THE IMPACT OF MOLECULAR DYNAMICS METHODS ON THE ACCURACY OF SIMULATIONS OF THE DISORDERED PROTEIN SIC1. Erik W. Martin , Tanja Mittag 2441-P os B oard #B133 ROLEOF INTRINSICHELICITYWITHINN-TERMINAL FLANKING SEQUENCES ON HUNTINGTIN AGGREGATION MECHA- NISMS. Kiersten M. Ruff , Kanchan Garai, Rohit V. Pappu 2442-P os B oard #B134 CORRELATION OF HELICAL PROPENSITY IN AMYLIN SEQUENCES WITH KNOWN AGGREGATION PROPENSITY. Gül H. Zerze , Cayla Miller, Jeetain Mittal 2443-P os B oard #B135 education travel awardee TAU(273-284): A MOLECULAR DYNAMICS STUDY OF INTRINSICALLY DISORDERED PROTEIN CONFORMATIONS IN THE PRESENCE OF OSMOLYTES. Zachary A. Levine , Luca Larini, Joan-Emma Shea 2444-P os B oard #B136 PROTEIN FOLDING AND COLLAPSE: THERMODYNAMICS OF AGGREGATIONOF GLY 5 VS CONCENTRATION IN SOLUTION. Deepti Karandur , Ka-Yiu Wong, B Montgomery Pettitt 2445-P os B oard #B137 PARSING THE CONTRIBUTIONS OF POLYPEPTIDE BACKBONES AND SIDECHAINS TO DENATURATION IN CONCENTRATED AQUEOUS SOLUTIONS OF UREA AND GUANIDINIUM CHLORIDE. Alex S. Holehouse , Nicholas Lyle, Andreas Vitalis, Devarajan Thirumalai, Rohit V. Pappu

2446-P os B oard #B138 THE STRUCTURE OF THE β -CASEIN PHOSPHOPEPTIDE CONSISTS OF TWO INDEPENDENT INTRINSICALLY DISORDERED DOMAINS. Muhammad A. Naqvi , Sarah Rauscher, Régis Pomès, Dérick Rousseau 2447-P os B oard #B139 MD SIMULATIONTRAJECTORIES OF MULTIPLE INTRINSICALLY DISORDERED PROTEINS REVEAL ORDER TO DISORDER TRANSITIONS THAT BEAR FUNCTIONAL SIGNIFICANCE. Tasneem Ali, Mattaparthi Venkata Satish Kumar, Saurabh Basu, Rajaram Swaminathan 2448-P os B oard #B140 PHYSICAL BIOINFORMATICS APPLIED TO INTRINSICALLY DISORDERED NUCLEOPORIN SEQUENCES REVEALS UNIVERSAL FUNCTIONAL FEATURES. David Ando , Michael Colvin, Michael Rexach, Ajay Gopinathan 2449-P os B oard #B141 EXTENSIVE USE OF HOST-MIMICKING MOTIFS SUPPORTS COMPLEX REGULATION OF VIRAL PROTEINS. Tzachi Hagai , Raul Andino, Madan M. Babu, Ariel Azia  Transcription (Boards #B142–#B166) 2450-P os B oard #B142 MECHANISM OF TRANSCRIPTIONAL BURSTING IN BACTERIA. Shasha Chong , Chongyi Chen, Hao Ge, X. Sunney Xie 2451-P os B oard #B143 WATCHING THE RNA POLYMERASE TRANSCRIPTION BY TIME-DEPENDENT SOAK-TRIGGER-FREEZE X-RAY CRYSTALLOGRAPHY. Katsuhiko Murakami 2452-P os B oard #B144 STRUCTURAL AND DYNAMIC REGULATION OF TFIID- MEDIATED TRANSCRIPTION INITIATION COMPLEX ASSEM- BLY BY THE TUMOR SUPPRESSOR P53 PROTEIN. Anna Piasecka, Lihua Song, Michael Cianfrocco, Vincent Wong, Shenglong Wang, Joseph Hargitai, William Rice, Eva Nogales, Robert A. Coleman, Wei-Li Liu 2453-P os B oard #B145 SINGLE MOLECULE PROBING OF P53’S ABILITY TO DYNAMICALLY REGULATE CHROMATIN STRUCTURE. Vincent Wong, Yu-Jen Chen, Charles Kenworthy, Lihua Song, Gina Dailey, Wei-Li Liu, Robert A. Coleman 2454-P os B oard #B146 SUBSTANTIAL NUCLEOTIDE SELECTION PRIOR TO FULL INSERTION OF THE NUCLEOTIDE IN T7 RNA POLYMERASE ELONGATION. Baogen Duan , Shaogui Wu, Yu Jin 2455-P os B oard #B147 COMPLETE DISSECTION OF TRANSCRIPTION ELONGATION REVEALS SLOW TRANSLOCATION OF RNA POLYMERASE II IN A LINEAR RATCHET MECHANISM. Manchuta Dangkulwanich , Toyotaka Ishibashi, Shixin Liu, Maria L. Kireeva, Lucyna Lubkowska, Mikhail Kahlev, Carlos J. Bustamante 2456-P os B oard #B148 LOCALIZATION ANDTRACKING OF SINGLE RNA POLYMERASE MOLECULES IN LIVE E. COLI. Somenath Bakshi , James Weisshaar 2457-P os B oard #B149 NEXT GENERATION SEQUENCING-BASED PARALLEL ANALYSIS OF MELTING KINETICS OF 4096 VARIANTS OF A BACTERIAL PROMOTER. Ewa Heyduk, Tomasz Heyduk

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Biophysical Society 58 th Annual Meeting, San Francisco, California