Program Book

3264-P lat 2:45 pm EXPERIMENTALLY INCREASING TITIN COMPLIANCE IN A NOVEL MOUSE MODEL ATTENUATES THE FRANK-STARLING MECHANISM BUT HAS A BENEFICIAL EFFECT ON DIASTOLE. Mei Methawasin , Kirk R. Hutchinson, Eun-Jeong Lee, John E. Smith III, Chandra Saripalli, Carlos G. Hidalgo, Henk L. Granzier 1:00 pm –3:00 pm , R oom 306 Platform Structure, Dynamics, and Allostery in Drug Target Interactions Co-Chairs Iris Antes, Technical University of Munich, Germany Roman Agafonov, Brandeis University 3265-P lat 1:00 pm FLEXIBLE CDOCKER: DEVELOPMENT AND APPLICATION OF A PSEUDO-EXPLICIT STRUCTURE-BASED DOCKING METHOD WITHIN CHARMM. Jessica K. Gagnon , Sean M. Law, Charles L. Brooks III 3266-P lat 1:15 pm HOWENZYMES ACCESS CAGED SUBSTRATES? UNDERSTANDING TARGETED HYDROLYSIS OF CYCLIC AMP BY PHOSPHODIESTERASE-PROTEIN KINASE A INTERACTIONS. Nikhil K. Tulsian , Srinath Krishnamurthy, Ganesh S. Anand 3267-P lat 1:30 pm CRYSTALLOGRAPHIC STRUCTURE OF A SMALL MOLECULE SIRT1 ACTIVATOR/ENZYME COMPLEX. Han Dai , Huizhen Zhao, Yong Jiang, Sharon M. Sweitzer, Beth Pietrak, Benjamin Schwartz, William Miller, Erding Hu, James L. Ellis 3268-P lat 1:45 pm A CONSERVED WATER-MEDIATED HYDROGEN BOND NETWORK UNDERLIES SELECTIVITY OF THE KINASE INHIBITOR BOSUTINIB. Nicholas M. Levinson , Steven G. Boxer 3269-P lat 2:00 pm MOLECULAR MECHANISMS UNDERLYING THE CLINICAL SUCCESS OF THE CANCER DRUG GLEEVEC. Roman V. Agafonov , Chris Wilson, Renee Otten, Vanessa Buosi, Dorothee Kern 3270-P lat 2:15 pm FINDING HIDDEN ALLOSTERIC SITES IN PROTEINS. Gregory R. Bowman , Phillip L. Geissler, Susan Marqusee 3271-P lat 2:30 pm COMPUTATIONAL PREDICTION OF PROTEIN-PEPTIDE BINDING. Iris Antes , Manuel Glaser, Atanas Patronov 3272-P lat 2:45 pm education travel awardee RASTERING THE INFLUENZA VIRUS SURFACE WITH MOLECULAR RULERS AND NANOPARTICLES TO DESIGN OPTIMAL MULTIVALENT INHIBITORS. Daniel Lauster , Victor Bandlow, Henry Memzcak, Sumati Bhatia, Christian Sieben, Walter Stöcklein, Oliver Seitz, Rainer Haag, Andreas Herrmann

3254-P lat 2:15 pm OVERCOMING REVERSE RATE DEPENDENCE IN VENTRICULAR CELL MODELS. Megan A. Cummins , Pavan Dalal, Marco Bugana, Stefano Severi, Eric Sobie 3255-P lat 2:30 pm ELUCIDATING METABOLIC VARIABILITY IN ISOGENIC MICROBIAL POPULATIONS ARISING DUE TO NOISE IN PROTEIN EXPRESSION. Piyush Labhsetwar , John Cole, Nathan Price, Zaida Luthey-Schulten 3256-P lat 2:45 pm COMPUTATIONAL MODELING OF GRANULOMA FORMATION IN TUBERCULOSIS YIELDS INSIGHTS INTO BOTH INFECTION AND TREATMENT. Nicholas A. Cilfone, Elsje Pienaar, Denise E. Kirschner, Jennifer J. Linderman

1:00 pm –3:00 pm , R oom 305 Platform Cardiac Muscle II

Co-Chairs Satish Rao, Icahn School of Medicine at Mount Sinai Steven Wu, South Dakota State University 3257-P lat 1:00 pm

E-C COUPLING ALTERATIONS AND SPONTANEOUS ACTIVITY IN MICE CARRYING CARDIAC TROPONIN T MUTATIONS. Josè Manuel Pioner , Raffaele Coppini, Cecilia Ferrantini, Benedetta Tosi, Luca Mazzoni, Rachel Moore, Elisabetta Cerbai, Alessandro Mugelli, Jil Tardiff, Chiara Tesi, Corrado Poggesi 3258-P lat 1:15 pm FAMILIAL HYPERTROPHIC CARDIOMYOPATHY: UNEQUAL EXPRESSION OF MUTANT AND WILDTYPE MYOSIN IN INDIVIDUAL MYOCYTES AS TRIGGER FOR FUNCTIONAL IMPAIRMENT OF THE HEART? Judith Montag , Snigdha Tripathi, Jan Köhler, Dunda E. Sebastian, Benjamin Seebohm, Dejan List, Matinmehr Faramarz, Andreas Perrot, Özcelik Celim, Antonio Francino, Fransisco Navarro-Lopéz, William J. McKenna, Jolanda van der Velden, Bernhard Brenner, Kraft Theresia 3259-P lat 1:30 pm MULTI-SCALE BIOMECHANICS IN A MARFAN SYNDROME MODEL OF DILATED CARDIOMYOPATHY. Satish Rao , Emily Chiu, Jason R. Cook, Jia-Jye Lee, Ludovic Bénard, Roger J. Hajjar, Francesco Ramirez, Kevin D. Costa 3260-P lat 1:45 pm EFFECTS OF NITROSYLATION ON CARDIAC MYOFILAMENT PROTEINS. Steven C. Wu , Maria E. Moutsoglou, John M. Robinson 3261-P lat 2:00 pm SARCOMERE LENGTH-VENTRICULAR FILLING PRESSURE RELATIONSHIP INTHE PERFUSEDMURINE HEART VISUALIZED WITH 2-PHOTON FLUORESCENCE MICROSCOPY. Michael E. Nance, Charmain A. Fernando, Anne K. Gibson, Laurin M. Hanft, Steven S. Segal, Kerry S. McDonald, Timothy L. Domeier 3262-P lat 2:15 pm REAL-TIME IMAGING OF SARCOMERE DYNAMICS IN THE MOUSE HEART IN VIVO. Fuyu Kobirumaki-Shimozawa , Kotaro Oyama, Akari Mizuno, Takako Terui, Togo Shimozawa, Takashi Ohki, Shin’ichi Ishiwata, Norio Fukuda 3263-P lat 2:30 pm END SYSTOLIC STRAIN RATE, NOT AFTERLOAD, CONTROLS MYOCARDIAL RELAXATION. Charles S. Chung , Kenneth S. Campbell

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Biophysical Society 58 th Annual Meeting, San Francisco, California