Program Book

3921-P os B oard #B649 VINCULIN-MEDIATED CYTOSKELETAL REMODELING MODULATES CARDIAC MORPHOLOGY AND CONTRACTILE FUNCTION DURING AGEING. Gaurav Kaushik , Alice Spenlehauer, Ayla Sessions, Danielle Pohl, Adriana Trujillo, Sanford I. Bernstein, Rolf Bodmer, Anthony Cammarato, Adam J. Engler 3922-P os B oard #B650 NOVEL LOCATIONS; FAMILIAR FUNCTIONS: OBSCURIN AT THE CARDIAC INTERCALATED DISC. Maegen A. Ackermann , Nicole A. Perry, Aikaterini Kontrogianni-Konstantopoulos 3923-P os B oard #B651 ACETYLATION AND PHOSPHORYLATION POST-TRANSLA- TIONAL MODIFICATIONS OF THE CAPZ BETA1 SUBUNIT REGULATE FRAP DYNAMICS LEADING TO MYOCYTE HYPER- TROPHY. Ying-Hsi Lin , Chad M. Warren, Brenda Russell 3924-P os B oard #B652 ACTIN CARBONYLATION IS HIGHER IN HUMAN HYPERTRO- PHIC CARDIOMYOPATHY DUE TO MYH7 MUTATIONS. Rosalie Witjas-Paalberends , Marcella Canton, Michelle Michels, Carolyn Ho, Corrado Poggesi, Fabio di Lisa, Jolanda van der Velden Microtubules, Their Motors, and Associated Proteins II (Boards #B653–#B682) 3925-P os B oard #B653 STRUCTURAL KINETICS OF THE MITOTIC KINESIN EG5. Joseph Muretta, William Behnke Parks, Karl Petersen, Adeline Goulet, Carolyn Moores, David D. Thomas, Steven Rosenfeld 3926-P os B oard #B654 STRUCTURAL BASIS FOR THE ASSEMBLY OF KINESIN-5 INTO BIPOLAR ANTI-PARALLEL TETRAMERS. Jessica Scholey, Stanley Nithianantham , Jonathan M. Scholey, Jawdat Al-Bassam 3927-P os B oard #B655 KINESIN-5 MOTILITY IS REGULATED BY THE RESIDUE CHEMISTRY OF LOOP-5. Rebecca S. Buckley , Victoria Dauphin, Thomas M. Huckaba, Sunyoung Kim 3928-P os B oard #B656 A CHIMERIC KINESIN-5 MOTOR TRACKS PLUS-ENDS OF MICROTUBULES. Yalei Chen , William O. Hancock 3929-P os B oard #B657 CUT7-DRIVEN MICROTUBULE SLIDING REVERSES DIRECTION DEPENDING ON MOTOR DENSITY. Mishan Britto, Kanwal Zehra, Adeline Goulet, Carolyn Moores, Robert A. Cross 3930-P os B oard #B658 SRC PHOSPHORYLATION REGULATES THE HUMAN KINESIN-5, EG5, AND DISRUPTS THE BINDING OF EG5 INHIBITORS. Kathleen M. Gifford , Joshua S. Waitzman, Taylor A. Poor, Barbara Mann, Melissa C. Gonzalez, Pat Wadsworth, Sarah E. Rice 3931-P os B oard #B659 ALLOSTERIC L5-DIRECTED INHIBITORS OF KINESIN-5 CAN CONTROL DIFFERENT BIOCHEMICAL INTERMEDIATES. Minmin Luo , Sunyoung Kim 3932-P os B oard #B660 PHOTO-REVERSIBLE INHIBITION OF MITOTIC KINESIN EG5 BY PHOTOCHROMIC STLC ANALOGUES COMPOSED OF AZOBENZENE. Kanako Tohyama , Kumiko Ishikawa, Shinsaku Maruta

3933-P os B oard #B661 PHOTO-REGULATION OF KINESIN EG5 ATPASE AND MOTOR ACTIVITY USING NOVEL PHOTOCHROMIC INHIBITOR COMPOSED OF SPIROPYRAN AND CYSTEINE. Kei Sadakane , Kumiko Ishikawa, Kanako Tohyama, Banri Yamanoha, Shinsaku Maruta 3934-P os B oard #B662 TRANSDUCER RESIDUES ARE THERMODYNAMICALLY COUPLED IN THE KINESIN-5 MOTOR DOMAIN. Jessica Richard , Hoang Nguyen, Elizabeth Kim, Sunyoung Kim 3935-P os B oard #B663 PHOTO-REGULATION OF MITOSIS KINESIN KIF18A USING PHOTOCHROMIC INHIBITOR. Seo Hideo , Kumiko Ishikawa, Shinsaku Maruta 3936-P os B oard #B664 PHOTOCONTROL OF MITOTIC KINESIN EG5 BY INCORPORATING OF PHOTOCHROMIC MOLECULE INTO THE FUNCTIONAL LOOP L5. Kumiko Ishikawa , Yuhki Tamura, Shinsaku Maruta 3937-P os B oard #B665 THE KINESIN-1 GATING MECHANISM STUDIED BY PRE-STEADY STATE KINETICS. Erik Jonsson , Ronald D. Vale 3938-P os B oard #B666 ENHANCED TRANSVERSE MOTION OF MULTIPLE KINESIN MOTOR CONFIGURATIONS VIA A DIFFUSIVE WEAKLY BOUND STATE. David Ando , Jing Xu, Ajay Gopinathan 3939-P os B oard #B667 KINESIN-2’S NECK-LINKER IS CRITICAL TO NAVIGATING OBSTACLES ON THE MICROTUBULE SURFACE MORE EFFICIENTLY THAN KINESIN-1. Christopher L. Berger , Gregory J. Hoeprich, Andrew R. Thompson, William O. Hancock 3940-P os B oard #B668 STRAIN-BASED MECHANISM OF KINESIN ATPASE. Wonmuk Hwang , Matthew J. Lang, Martin Karplus 3941-P os B oard #B669 DEVELOPMENT OF MOLECULAR SHUTTLE REGULATED BY EXTERNAL STIMULATION UTILIZING KINESIN ATP DRIVEN MOTOR. Naozumi Numata , Kazunori Kondo, Shinsaku Maruta 3942-P os B oard #B670 COLLECTIVE MOTIONS AND DYNAMICAL COUPLINGS IN THE KINESIN MOTOR DOMAIN. Guido Scarabelli , Barry J. Grant 3943-P os B oard #B671 INTRODUCING A KINESIN-INSPIRED NANOMOTOR CONCEPT. Martin J. Zuckermann , Elizabeth H.C. Bromley, Christopher N. Angstmann, Gerhard A. Blab, Nancy R. Forde, Heiner Linke, Paul M.G. Curmi 3944-P os B oard #B672 SIMULATIONS OF NECK-LINKER MODIFIED AND ONE HEAD LOADED KINESINS. Norbert Orgován , Imre Derényi 3945-P os B oard #B673 STRAIN-DEPENDENT REGULATION OF THE KINESIN-1’S CATALYTIC ACTIVITY AS STUDIED BY DISULFIDE-CROSSLINKING OF THE NECK LINKER. Yamato Niitani , Erik Jonsson, Ronald D. Vale, Michio Tomishige 3946-P os B oard #B674 KINESIN MOTILITY ON MICROTUBULE BUNDLES. Leslie Conway , Jennifer L. Ross

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Biophysical Society 58 th Annual Meeting, San Francisco, California