Program Book

Membrane Receptors and Signal Transduction I (Boards #B288–#B313) 533-P os B oard #B288 STRUCTURAL BASIS FOR MODULATION OF A GPCR BY ALLOSTERIC DRUGS. Ron O. Dror , Hillary F. Green, Celine Valant, David W. Borhani, James R. Valcourt, Albert C. Pan, Daniel H. Arlow, Meritxell Canals, J. Robert Lane, Raphaël Rahmani, Jonathan B. Baell, Patrick M. Sexton, Arthur Christopoulos, David E. Shaw 534-P os B oard #B289 education travel awardee SPECIFIC REGULATION OF TRANSITION RATES BETWEEN ACTIVE AND INACTIVE STATES OF THE METABOTROPIC GLUTAMATE RECEPTOR DETERMINES AGONIST EFFICACY. Linnéa Olofsson, Suren Felekyan, Etienne Doumazane, Pauline Scholler, Ludovic Fabre, Jurriaan Zwier, Jean-Philippe Pin, Claus Seidel, Philippe Rondard, Emmanuel Margeat 535-P os B oard #B290 Daniel Rolfe, Gregory Weitsman, Florian Kampmeier, Martyn Winn, Laura Zanetti-Domingues, Marisa L. Martin-Fernandez, Tony Ng 536-P os B oard #B291 SINGLE-MOLECULE MICROSCOPY DECIPHERS THE RELATION BETWEEN TRAFFICKING AND SIGNALING OF THE NK1 RECEPTOR IN LIVINGS CELLS. Luc Veya , Joachim Piguet, Horst Vogel 537-P os B oard #B292 ACTIVATION OF THE M2 MUSCARINIC RECEPTOR AND COMPUTER-AIDED DESIGN OF RECEPTOR-SELECTIVE ALLOSTERIC DRUGS. Yinglong Miao , J. Andrew McCammon 538-P os B oard #B293 NATURE OF THE M2 MUSCARINIC RECEPTOR SIGNALING COMPLEX REVEALED BY DUAL-COLOR FCS AND FRET. Yuchong Li , Rabindra V. Shivnaraine, Dennis D. Fernandes, Huiqiao Ji, Fei Huang, James W. Wells, Claudiu C. Gradinaru 539-P os B oard #B294 G PROTEIN ACTIVATION: A DYNAMIC PROCESS. Labe Black , Celestine Thomas, JB Alexander Ross, Stephen R. Sprang 540-P os B oard #B295 SINGLE MOLECULE IMAGING REVEALS THAT ACTIVATING KINASE DOMAIN MUTATIONS REDUCE EGFR MOBILITY AND ENHANCE DIMERIZATION. Christopher C. Valley , Shalini T. Low-Nam, Mara P. Steinkamp, Bridget S. Wilson, Keith A. Lidke, Diane S. Lidke 541-P os B oard #B296 TOTAL INTERNAL REFLECTION FLUORESCENCE (TIRF) MICROSCOPY GUIDED QUANTIFICATION OF GLUT4 TRANSLOCATION FOR THE IDENTIFICATION OF INSULIN MIMETIC DRUGS. Verena Stadlbauer, Peter Lanzerstorfer, Daniela Borgmann, Jürgen Wruss, Klaus Schröder, Stephan Winkler, Otmar Höglinger, Julian Weghuber 542-P os B oard #B297 THE MEMBRANE PROXIMAL REGION OF THE HUMAN CANNABINOID RECEPTOR CB1 N-TERMINUS ALLOSTERICALLY MODULATES LIGAND AFFINITY. Jonathan F. Fay , David L. Farrens MODULATION OF EGFR DIMER STABILITY BY MANIPULATION OF PHOSPHORILATION IN SITU. Oana C. Coban , Daniel R. Matthews, Simon Ameer-Beg,

521-P os B oard #B276 CHARGED PROTEIN-LIPID INTERACTIONS IN BILAYERS WITH WIDE-RANGING THICKNESS. Peiran Chen , Igor Vorobyov, Toby W. Allen 522-P os B oard #B277 CAPTURING SPONTANEOUS BINDING OF HUMAN ISLET AMYLOID POLYPEPTIDE TO ANIONIC MEMBRANES USING A HIGHLY MOBILE MEMBRANE MIMETIC MODEL. Katrine K. Skeby , Emad Tajkhorshid, Schiøtt Birgit 523-P os B oard #B278 MOLECULAR DYNAMICS STUDIES OF PEGYLATED ANTIMICROBIAL PEPTIDES WITH LIPID BILAYERS. Eol Han 524-P os B oard #B279 DOUBLE-BELT A NOVEL STRUCTURE OF MEMBRANE PORE. Robert Vacha , Daan Frenkel 525-P os B oard #B280 INTERACTION OF THE INWARD RECTIFIER POTASSIUM CHANNEL KIR 2.2 WITH PHOSPHATIDYLSERINE. Mercedes Alfonso Prieto , Lucie Delemotte, Michael L. Klein 526-P os B oard #B281 PERMEATION OF LIPIDATED PROTEIN IN BILAYER USING UNBIASED SIMULATIONS REVEALS SIGNATURE MOTIF FOR PROTEIN-MEMBRANE BINDING. Lipi Thukral , Durba Sengupta, Rajesh S. Gokhale 527-P os B oard #B282 STRUCTURAL BASIS OF LIPID EXCHANGE IN THE OXYSTEROL-BINDING PROTEIN HOMOLOGUE (OSH) FAMILY. Stefano Vanni , Joachim Moser von Filseck, Bruno Mesmin, Bruno Antonny, Guillaume Drin 528-P os B oard #B283 STUDY OF THE MECANISM OF ACTION OF A HYBRID PEPTIDE IN POPG:POPC BILAYERS. Gabriel C. Da Hora , Thereza Amélia Soares 529-P os B oard #B284 OLIGOMERIZATION OF HUNTINGTIN N-TERMINAL FRAGMENT ON A PHOSPHOLIPID BILAYER REVEALED BY MOLECULAR DYNAMICS SIMULATIONS. Sebastien Cote , Vincent Binette, Evgeniy S. Salnikov, Burkhard Bechinger, Guanghong Wei, Normand Mousseau 530-P os B oard #B285 DYNAMICS OF TRANSITION METAL TRANSPORTING P-TYPE ATPASES IN NATIVE MEMBRANES. Henriette E. Autzen , Phillip J. Stansfeld, Oleg E. Sitsel, Kaituo Wang, Gabriele Meloni, Pontus Gourdon, Mark S. P. Sansom, Poul Nissen 531-P os B oard #B286 COMPARING SYMMETRIC AND ASYMMETRIC BILAYER- PROTEIN INTERACTIONS USING MOLECULAR DYNAMICS. Curtis Balusek , James C. Gumbart 532-P os B oard #B287 COARSE-GRAINED SIMULATIONS OF PEPTIDE AGGREGATION ON SURFACES. Alex Morriss-Andrews , Joan-Emma Shea

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Biophysical Society 58 th Annual Meeting, San Francisco, California