Program Book

1250-P lat 5:00 pm ATP ACTS AS SWITCH FOR TOGGLING CALRETICULIN BETWEEN ITS LECTIN AND CHAPERONE FUNCTION. Karunesh Arora , Charles L. Brooks III 1251-P lat 5:15 pm ALLOSTERIC OPENING OF THE POLYPEPTIDE-BINDING SITE WHEN AN HSP70 BINDS ATP. Qinglian Liu , Ruifeng Qi, Evans Sarbeng, Qun Liu, Katherine Le, Xinping Xu, Hongya Xu, Jiao Yang, Jennifer Wong, Christina Vorvis, Wayne Hendrickson, Lei Zhou 1252-P lat 5:30 pm STABILITY AND DYNAMICS OF ALPHA CRYSTALLIN OLIGOMERS PROBED BY FRET AND FCS REVEAL PERSISTENT OLIGOMERIZATION UNDER DILUTE CONDITIONS. Alexander H. Pearlman, Satyajeet Salvi, Patricia B. O’Hara, James A. Hebda 1253-P lat 5:45 pm ENHANCED CHAPERONE CLUSTERING FACILITATES PROTEIN FOLDING IN THE ENDOPLASMIC RETICULUM OF YEAST. Marc Griesemer , Carissa Young, Anne S. Robinson, Linda Petzold Co-Chairs Jefferson Knight, University of Colorado, Denver Shelli Frey, Gettysburg College 1254-P lat 4:00 pm MOLECULAR MECHANISMS OF HIGH-AFFINITY PHOS- PHOINOSITIDE BINDING BY THE TANDEM C2 DOMAINS OF GRANUPHILIN/SLP-4. Tatyana A. Lyakhova, Jefferson Knight 1255-P lat 4:15 pm NMR OF CONDITIONAL PERIPHERAL MEMBRANE PROTEINS. Krystal A. Morales, Mikaela D. Stewart, Tatyana I. Igumenova 1256-P lat 4:30 pm THE ROLE OF PROTEIN AND MEMBRANE CONTEXT IN THE INTERACTION OF POLYGLUTAMINE PEPTIDES WITH LIPID MEMBRANES. Warren A. Campbell, David Van Doren , Kathleen A. Burke, Justin Legleiter, Shelli L. Frey 1257-P lat 4:45 pm ASSOCIATION OF α -SYNUCLEIN WITH LIPID VESICLES. STOPPED-FLOW KINETICS OF CONCERTED BINDING AND CONFORMATIONAL CHANGE. Thomas M. Jovin , Volodymyr V. Shvadchak, Remco Siero, Lisandro J. Falomir-Lockhart, Vinod Subramaniam 1258-P lat 5:00 pm FLUORINATED AROMATIC AMINO ACIDS DISTINGUISH CATION-π INTERACTIONS FROM MEMBRANE INSERTION. Tao He , Anne Gershenson, Jianmin Gao, Mary F. Roberts 1259-P lat 5:15 pm INVITRO RECONSTITUTIONOFTRANSCELLULARTUNNELS CLOSURE. Coline Prévost , John Manzi, Hongxia Zhao, Pekka Lappalainen, Emmanuel Lemichez, Andrew Callan-Jones, Patricia Bassereau 1260-P lat 5:30 pm THE ASSEMBLY, STRUCTURE AND ACTIVATION OF INFLUENZA A M2 TRANSMEMBRANE DOMAIN DEPENDS ON LIPID MEMBRANE THICKNESS AND COMPOSITION. Elka R. Georgieva , Haley D. Norman, Peter P. Borbat, Jack H. Freed 4:00 pm –6:00 pm , R oom 305 Platform Protein-Lipid Interactions II

1261-P lat 5:45 pm HSP70 ASSOCIATES WITH PHOSPHATIDYLSERINE MEMBRANES VIA THE PEPTIDE BINDING DOMAIN. Antonio De Maio , Gabrielle Armijo, Victor Lopez, Derek Gonzales, Jonathan Okerblom, Nelson Arispe, David M. Cauvi

4:00 pm –6:00 pm , R oom 306 Platform Computational Methods

Co-Chairs David Mobley, University of California, Irvine Peter Mulligan, Stanford University 1262-P lat 4:00 pm BAYESIAN STRUCTURE DETERMINATION FROM SPARSE SINGLE MOLECULE X-RAY DIFFRACTION IMAGES. Michal Walczak , Helmut Grubmueller 1263-P lat 4:15 pm XMDFF: MOLECULAR DYNAMICS FLEXIBLE FITTING OF LOW-RESOLUTION X-RAY STRUCTURES. Abhishek Singharoy , Ryan McGreevy, Qufei Li, Jingfen Zhang, Eduardo Perozo, Klaus Schulten 1264-P lat 4:30 pm I-ATTRACT: A NEW FLEXIBLE DOCKING APPROACH FOR INVESTIGATING PROTEIN PROTEIN INTERACTIONS. Christina Schindler , Martin Zacharias 1265-P lat 4:45 pm PREDICTING CHARGED-LIGAND BINDING FROMMOLECULAR SIMULATIONS. David L. Mobley , Gabriel J. Rocklin 1266-P lat 5:00 pm RIBOSOMAL KINETICS AND CONCERTED MOTIONS FROM NANOSECONDS TO SECONDS. Christian Blau , Lars V. Bock, Gunnar F. Schröder, Iakov Davydov, Niels Fischer, Holger Stark, Marina V. Rodnina, Andrea C. Vaiana, Helmut Grubmuller 1267-P lat 5:15 pm ACCELERATE SAMPLING IN ATOMISTIC ENERGY LANDSCAPES USING TOPOLOGY-BASED COARSE-GRAINED MODELS. Weihng Zhang , Jianhan Chen 1268-P lat 5:30 pm ANALYSIS OF SIZE AND COMPOSITIONAL DISTRIBUTIONS OF PLEOMORPHIC ENSEMBLES ARISING FROM CLUSTERING OF MULTIVALENT BIOLOGICAL MOLECULES. Cibele V. Falkenberg , Michael L. Blinov, Leslie M. Loew 1269-P lat 5:45 pm DYNAMIC RE-DISCRETIZATION ALLOWS SIMULATION OF BIOPOLYMERS ACROSS LENGTH-SCALES. Peter Mulligan , Elena F. Koslover, Andrew J. Spakowitz

5:00 pm –6:30 pm , R oom 123 Exhibitor Presentation HEKA Elektronik

HEKA Electrophysiology Update For over 40 years, HEKA Elektronik has provided innovative products, expert tech support and unmatched service to their customers. HEKA’s commitment to technological innovation is reflected by consistent updating of both hardware and software. While yesterday’s gold standards try to keep pace with the latest research techniques, HEKA takes the lead. By popular demand, HEKA is hosting a series of user meetings with tutorial presentations. On one hand, some of the new products will be showcased

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Biophysical Society 58 th Annual Meeting, San Francisco, California