Program Book

1599-P os B oard #B329 DISTINCT ORAI-COUPLING DOMAINS IN STIM1 AND STIM2 DEFINE THE ORAI-ACTIVATING SITE. Xizhuo Wang , Youjun Wang, Yandong Zhou, Eunan Hendron, Salvatore Mancarella, Mark D. Andrake, Brad S. Rothberg, Jonathan Soboloff, Donald L. Gill 1600-P os B oard #B330 STIM1 CYTOSOLIC COILED-COIL INTERACTIONS IN THE RESTING AND ACTIVATED STATE. Marc Fahrner , Martin Muik, Rainer Schindl, Carmen Hoeglinger, Christoph Romanin 1601-P os B oard #B331 STIM1 BINDS TO PAIRS OF ORAI1 SUBUNITS TO OPEN THE CRAC CHANNEL. Michelle Yen , Ludmila A. Lokteva, Richard S. Lewis 1602-P os B oard #B332 MECHANISM OF ACTIVATION OF CALCIUM CHANNEL ORAI1 BY ITS REGULATORY PARTNER STIM1. Aparna Gudlur , Ariel Quintana, Yubin Zhou, Anjana Rao, Patrick G. Hogan 1603-P os B oard #B333 MECHANISM OF ACTIVATION OF STORE-OPERATED CALCIUM ENTRY BY 2-AMINOETHOXYDIPHENYL BORATE. Yandong Zhou , Youjun Wang, Xizhuo Wang, Lucas Occhiena, Daniel Y. Chung, Aomin Sun, Donald L. Gill 1604-P os B oard #B334 EXPLORING THE ROLE OF PORE WATERS AND COUNTERIONS IN THE CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL CONDUCTANCE WITH COMPUTATION. Hao Dong , Giacomo Fiorin, Michael L. Klein 1605-P os B oard #B335 PH DEPENDENCE OF ORAI1 AND ORAI3 STORE-OPERATED CURRENT. Andriy V. Yeromin , Olga Safrina, Michael D. Cahalan 1606-P os B oard #B336 DISSECTING THE MOLECULAR MECHANISM OF 2-APB-IN- DUCED INHIBITION OF STIM1-ORAI1 COUPLING. Youjun Wang , Xizhuo Wang, Yandong Zhou, Eunan Hendron, Lucas Occhiena, Ming Wei, Donald L. Gill 1607-P os B oard #B337 ORAI3 TM3 POINT MUTATION G158C ALTERS KINETICS OF 2-APB-INDUCED GATING BY DISULFIDE BRIDGE FORMATION WITH TM2 C101. Anna Amcheslavsky 1608-P os B oard #B338 INTERPLAY OF ORAI1-LOOP3 WITH EXTRACELLULAR CA 2+ BINDING SITES IN LOOP1 CONTROLS CRAC CHANNEL ACTIVITY. Irene Frischauf , Rainer Schindl, Vasilina Zayats, Michael Deix, Anna Hochreiter, Barbora Svobodova, Rüdiger Ettrich, Christoph Romanin 1609-P os B oard #B339 NOVEL TRANS-MEMBRANE MUTATION SWITCHES ORAI1 TO A CONSTITUTIVELY ACTIVE AND CA 2+ SELECTIVE CHANNEL. Rainer Schindl , Irene Frischauf, Vasilina Zayats, Barbora Svobodova, Michael Deix, Martin Muik, Anna Hochreiter, Rüdiger Ettrich, Christoph Romanin 1610-P os B oard #B340 ATOMISTIC MOLECULAR DYNAMICS SIMULATIONS OF DROSOPHILA ORAI IN A HYDRATED LIPID BILAYER. Mona L. Wood , Anna Amcheslavsky, Eric Wong, J. Alfredo Freites, Michael D. Cahalan, Douglas J. Tobias

1589-P os B oard #B319 A NOVEL INHIBITORY PATHWAY MODULATES THE FRACTION OF RELEASE-COMPETENT SYNAPTIC VESICLES. Victor A. Cazares , Arasakumar Subramani, Widmann Hoerauf, Johnny James Saldate, Edward L. Stuenkel 1590-P os B oard #B320 THE ROLE OF DOC2B IN DEPOLARIZATION-EVOKED AND G PROTEIN-COUPLED RECEPTOR MODULATED EXOCYTOSIS IN MOUSE CHROMAFFIN CELLS. Claudia S. Bauer, Alexander J. Groffen, Elizabeth P. Seward Nucleo-Cytoplasm Transport (Boards #B321–#B326B) 1591-P os B oard #B321 A RAN-DEPENDENT IMPORTIN-BETA/NUP153 BARRIER IN THE NUCLEAR PORE COMPLEX. Jeffrey H. Tang , Alan R. Lowe, Jaime Yassif, Michael Graf, William Y. C. Huang, Jay T. Groves, Karsten Weis, Jan T. Liphardt 1592-P os B oard #B322 CONFORMATIONAL BEHAVIOR OF THE CONFINED FG-REPEAT DOMAINS IN THE NUCLEAR PORE. Ruhollah Moussavi-Baygi, Mohammad R. Mofrad 1593-P os B oard #B323 SIMPLE PHYSICAL CONSIDERATIONS EXPLAIN THE CONFORMATIONAL TRANSITIONS OF THE FG- NUCLEOPORINS INDUCED BY THE TRANSPORT FACTORS. Anton Zilman , Michael Opferman, David Jasnow, Rob Coalson 1594-P os B oard #B324 CHARACTERIZATION OF THE SELECTIVE BARRIER IN NUCLEAR PORE COMPLEX. Jiong Ma , Alexander Goryaynov, Weidong Yang 1595-P os B oard #B325 COMPUTATIONAL STUDY OF BINDING BETWEEN DDX3 AND HIV-1 MRNA NUCLEOCYTOPLASMIC EXPORT COMPLEX. S. Hanif Mahboobi 1596.1-P os B oard #B326A CELLULAR METABOLISM FLUIDIZES THE GLASSY BACTERIAL CYTOPLASM. Bradley Parry , Ivan Surovtsev, Matthew Cabeen, Corey O’Hern, Eric Dufresne, Christine Jacobs-Wagner 1596.2-P os B oard #B326B cpow travel awardee LAMIN-A IS MECHANOSENSITIVE TO MATRIX STIFFNESS AND COUPLES TO THE RETINOIC ACID PATHWAY IN DIFFERENTIATION. Irena L. Ivanovska, Joe Swift, Dennis E. Discher  Calcium Release Activated Calcium Channels (Boards #B327–#B347) 1597-P os B oard #B327 STRUCTURAL MODELING OF HEXAMERIC AND TETRAMERIC ION CONDUCTION PATHWAYS OF ORAI1 CHANNEL. Alla Fomina , Vladimir Yarov-Yarovoy 1598-P os B oard #B328 COMPLEX FUNCTION OF STIM1 IN THE ACTIVATION OF STORE-INDEPENDENT ORAI CHANNELS. Xuexin Zhang , Wei Zhang, José González-Cobos, Mohamed Trebak

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Biophysical Society 58 th Annual Meeting, San Francisco, California