Program Book

1659-P os B oard #B389 ACIDOSIS: A POSSIBLE TRIGGER FOR BRUGADA SYNDROME ASSOCIATED ARRHYTHMIA. Colin H. Peters , Peter C. Ruben 1660-P os B oard #B390 INAL IN THE PATHOPHYSIOLOGY OF INSULIN-SECRETION: A “CARDIAC” PARADIGM IN A NEW CELL TYPE. Riccardo Rizzetto , Marcella Rocchetti, Alice Villa, Luca Sala, Carlotta Ronchi, Isabella Molinari, Mara Ferrandi, Antonio Zaza 1661-P os B oard #B391 REDUCTIONOF CARDIAC SODIUMCURRENT IS INDEPENDENT OF CARDIAC HYPERTROPHY IN MICE WITH CARDIAC SPECIFIC OVEREXPRESSION OF TYPE 1 ANGIOTENSIN II RECEPTOR. Sophie Mathieu , Nabil El Khoury, Katy Rivard, Mona Nemer, Céline Fiset 1662-P os B oard #B392 DIFFERENTIAL THERMOSENSITIVITY IN NAV1.5 MUTATIONS ASSOCIATED WITH LONG QT AND BRUGADA SYNDROMES. Mena Abdelsayed, Peter C. Ruben 1663-P os B oard #B393 TRAFFICKING DEFECTIVE MUTATIONS MODULATE NA V 1.5 NGLYCOSYLATION STATES. Aurelie Mercier, Romain Clement, Patrick Bois, Aurelien Chatelier 1664-P os B oard #B394 SELECTIVE INHIBITION OF LATE NA + CURRENT REDUCES ARRHYTHMIC ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RAT MYOCYTES. Nesrine El-Bizri , Steven Nguyen, Gongxin Liu, Luiz Belardinelli, Sridharan Rajamani 1665-P os B oard #B395 DYNAMIC LATE NA CURRENT DURING CARDIAC ACTION POTENTIAL REVEALED BY A SPECIFIC AND POTENT INHIBITOR GS967. Zhong Jian, Balazs Horvath, Tamas Banyazs, Leighton T. Izu, Yi-Je Chen, Sridharan Rajamani, Kenneth Ginsburg, Julie Bossuyt, Donald M. Bers, Luiz Belardinelli, Ye Chen-Izu 1666-P os B oard #B396 INCREASED ACTIVITY OF NAV1.9 SODIUM CHANNELS CAUSES LOSS OF PAIN PERCEPTION. Enrico Leipold , R. Oliver Goral, Stefan H. Heinemann, Christian A. Hübner, Ingo Kurth 1667-P os B oard #B397 EPILEPSY INCREASES THE CONTRIBUTION OF TETRODOXIN-SENSITIVE CHANNELS TOTHE CARDIAC SODIUM CURRENT. Michael Biet, Nathalie Morin, Sandra Duss, Nathalie Sanon, Lionel Carmant, Robert Dumaine  Voltage-gated Ca Channels II (Boards #B398–#B417) 1668-P os B oard #B398 PROFILING MECHANISMS OF RGK INHIBITION ACROSS THE FAMILY OF HIGH-VOLTAGE-ACTIVATED CAV1/CAV2 CALCIUM CHANNELS. Akil A. Puckerin , Donald D. Chang, Henry M. Colecraft 1669-P os B oard #B399 LEUCINE-RICH REPEAT CONTAINING 10 (LRRC10) PROTEIN IS A NOVEL REGULATOR OF CARDIAC CAV1.2 L-TYPE CALCIUM CHANNELS. Courtney R. Reynolds , Li Feng, Matthew J. Brody, Lee Youngsook, Ravi C. Balijepalli

1670-P os B oard #B400 A UNIFIED FRAMEWORK FOR CALCIUM CHANNEL MODULATION BY CALCIUM BINDING PROTEINS. Philemon S. Yang, Manu Ben Johny, David T. Yue 1671-P os B oard #B401 C-TERMINAL MODULATION OF CAV1.3 L-TYPE CALCIUM CHANNELS MODIFIES THEIR GATING PROPERTIES IN COCHLEAR INNER HAIR CELLS. Stephanie Eckrich, Anja Scharinger, Stefan Muenkner , Kai Schönig, Amy Lee, Dusan Bartsch, Alexandra Koschak, Martina Sinnegger-Brauns, Dietmar Hecker, Bernhard Schick, Joerg Striessnig, Jutta Engel 1672-P os B oard #B402 USING EXOFACIALLY TAGGED FUNCTIONAL CAV2.2 TO INVESTIGATE THE MODULATION OF PORE SUBUNIT TRAFFICKING BY AUXILIARY CALCIUM CHANNEL SUBUNITS. John S. Cassidy , Annette C. Dolphin 1673-P os B oard #B403 CARDIOMYOCYTE ENDPOINTS DISTINGUISHNON-CANONICAL REGULATION OF THE RGK GTPASES RAD AND REM. Donald D. Chang , Henry M. Colecraft 1674-P os B oard #B404 DIFFERENTIAL CA V 2.1 AND CA V 2.3 CHANNEL INHIBITION BY BACLOFEN AND α -CONOTOXIN VC1.1 VIA GABA B RECEPTOR ACTIVATION. Geza Berecki , Jeffrey R. McArthur, Hartmut Cuny, Richard J. Clark, David J. Adams 1675-P os B oard #B405 CALORIMETRIC AND NMR CHARACTERIZATION OF A REM2 G-DOMAIN INTERACTION WITH THE SH3-GK CORE OF THE CA 2+ CHANNEL BETA4 SUBUNIT. Xingfu Xu , William A. Horne 1676-P os B oard #B406 A TIMOTHY SYNDROME CAUSING MUTATION PERTURBS VOLTAGE SENSOR OPERATION INHUMAN CA V 1.2 CHANNELS. Nicoletta Savalli , Antonios Pantazis, Daniel Sigg, Alan Neely, Riccardo Olcese 1677-P os B oard #B407 THREE SPLICE VARIANTS OF THE CALCIUM CHANNEL BETA4 SUBUNIT DISPLAY DIFFERENTIAL TARGETING AND GENE REGULATION IN NEURONS. Solmaz Etemad, Gerald J. Obermair, Verena Burtscher, Daniel Bindreither, Bernhard E. Flucher 1678-P os B oard #B408 IDENTIFICATION OF A DETERMINANT OF HIGH AFFINITY CALCIUM BINDING IN THE SELECTIVITY FILTER OF A MAMMALIAN CALCIUM CHANNEL. Felix Findeisen , David Shaya, Fayal Abderemane-Ali, Cristina Arrigoni, Gildas Loussouarn, Daniel L. Minor, Jr. 1679-P os B oard #B409 FUNCTIONAL CLUSTERING OF L-TYPE CAV1.3 CHANNELS. Claudia M. Moreno , Rose E. Dixon, Can Yuan, Marc D. Binder, Luis F. Santana 1680-P os B oard #B410 CALCIUM CHANNEL α 2 δ -1 SUBUNIT KNOCKOUT CAUSES DIABETES DUE TO IMPAIRED INSULIN RELEASE. Petronel Tuluc , Vincenzo Mastrolia, Mathias Drach, Sylvia M. Flucher, Erik Renström, Jörg Striessnig, Bernhard E. Flucher 1681-P os B oard #B411 CHEMICAL-BIOLOGICAL GENERATOR OF STEP INCREASES IN CALMODULIN REVEALS DUAL MODULATION OF L-TYPE CA 2+ CHANNELS. Paul Adams , Manu Ben Johny, Ivy E. Dick, David T. Yue

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Biophysical Society 58 th Annual Meeting, San Francisco, California