Spatial Organization of Biological Fuctions | BPS Thematic Meeting

Spatial Organization of Biological Functions Meeting

Wednesday Speaker Abstracts

IMAG(IN)ING SALMONELLA LIFESTYLES Linda Kenney Mechanobiologics Inc, USA No Abstract

NUCLEOSOME DYNAMICS AND HISTONE MODIFICATION IN EPIGENETIC INHERITANCE Sai Samarpita 1 ; Ranjith Padinhateeri 1 ; 1 Indian Institute of Technology, Bombay, India How epigenetic information is inherited during cell division remains an interesting open question. While basic models have been proposed to investigate this problem, none so far have accounted for nucleosome binding, dissociation, and sliding dynamics. Based on recent experimental data, we simulate a model that includes nucleosome binding, dissociation, and sliding, and investigate how the interplay between nucleosome dynamics and deacetylation/methylation spreading reactions determine histone modification spreading and inheritance. First, we present how nucleosome density is affected by acetylation and methylation dynamics. We then extend this model to study the inheritance of histone modifications.

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