Spatial Organization of Biological Fuctions | BPS Thematic Meeting

Spatial Organization of Biological Functions Meeting

Poster Abstracts

TBD Vijay Krishnamurthy International Centre for Theoretical Sciences, India No Abstract

MECHANOCHEMICAL FEEDBACK IN HYDRA REGENERATION Kinneret Keren Technion International, Israel No Abstract

ELECTRONIC ENERGY MIGRATION IN PROTEINS AND THEIR ASSEMBLIES Aarat Kalra ; 1 Indian Institute of Technology Delhi, Biomedical Engineering, Delhi, India 2 All India Institute of Medical Sciences, Biomedical Engineering, Delhi, India 3 Indian Institute of Technology Delhi, Amar Nath and Shashi Khosla School of Information Technology, Delhi, India UV light absorption and subsequent energy transfer by aromatic residues can be harnessed to direct and dissipate electronic energy in proteins. However, the relationship of a protein’s electronic energy migration length with its other biochemical functions is not well understood. Here, we predict electronic energy migration lengths for the complete protein data bank (PDB) using a kinetic Monte Carlo simulation. We simulate repeated energy transfer through Forster Resonance Energy Transfer (FRET) and Dexter Energy Transfer (DET) hopping between aromatic residues, balancing energy transfer rates with intrinsic excited state lifetimes. We find patterns correlating the electronic energy migration length of a protein with its structure and function. We also show that electronic energy migration lengths are significant in idealized one-, two-, and three-dimensional aromatic residue lattices resembling various intracellular structures. Our work provides detailed insight into the relationship of a proteins’ light harvesting ability and its structural and functional properties.

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