BPS Program Book 2014

Voltage-gated K Channels II (Boards #B399–#B428)

2720-P os B oard #B412 SHAKER KV CHANNEL’S SUGAR REMOTION IN REAL-TIME. Angelica M. Lopez-Rodriguez , Gaurav Venkataraman, Miguel Holmgren 2721-P os B oard #B413 LOCKING THE OPEN STATE OF A VOLTAGE-DEPENDENT CONCATEMER POTASSIUM CHANNEL WITH METAL BRIDGES. Angel A. de la Cruz Landrau , Miguel Holmgren 2722-P os B oard #B414 MUTATIONS IN THE CAVITY AFFECT THE RATE OF SLOW INACTIVATION IN SHAKER K + CHANNELS. Tibor G. Szanto, Orsolya Szilagyi, Florina Zakany, Gyorgy Panyi 2723-P os B oard #B415 VOLTAGE SENSOR DOMAIN MUTATIONS INVOLVED IN THE KV1.2 CHANNEL ACTIVATION VIA MD SIMULATIONS. Cristiano Amaral 2724-P os B oard #B416 ATOMISTIC MODELING OF ION CONDUCTION THROUGH VOLTAGE-SENSING DOMAINS. Mona L. Wood, J. Alfredo Freites , Francesco Tombola, Stephen H. White, Douglas J. Tobias 2725-P os B oard #B417 CAUTION IS NEEDED IN INTERPRETATION OF ARGàCYS MUTATION + MTS REACTION IN THE S4 TRANSMEMBRANE SEGMENT OF A VOLTAGE SENSING DOMAIN (VSD) OF A VOLTAGE GATED CHANNEL: RESULTS OF QUANTUM CALCULATIONS. Alisher M. Kariev, Michael E. Green 2726-P os B oard #B418 QUANTUM CALCULATIONS SHOW HOW THE WATER AT THE GATE OF THE VOLTAGE GATED KV1.2 CHANNEL PLAYS A MAJOR ROLE IN DETERMINING CONDUCTION THROUGH THE GATE. Alisher M. Kariev , Philipa Njau, Michael E. Green 2727-P os B oard #B419 TURNING A SMALL INTO LARGE CONDUCTANCE K-CHANNEL - HOW FAR CAN WE GO? Ignacio Diaz-Franulic , Nieves Navarro, Fernando Gonzalez-Nilo, Romina V. Sepulveda, David Naranjo 2728-P os B oard #B420 AMINO ACID SUBSTITUTIONS FOR T75 IN KCSA ALTER ION SELECTIVITY. Melia Tabbakhian, Van Ngo, Stephan Haas, Robert Farley 2729-P os B oard #B421 ION PERMEATION EFFICIENCY THROUGH POTASSIUM CHANNELS. David A. Kopfer , Chen Song, Ulrich Zachariae, Bert L. de Groot 2730-P os B oard #B422 STRATEGIES TO ACHIEVE SELECTIVE CONDUCTANCE IN K- AND NA- SELECTIVE ION CHANNELS. Yibo Wang , Chunfeng Zhao, Sergei Yu. Noskov 2731-P os B oard #B423 INSIGHTS INTO THE ION PERMEATION PROCESS OF HIGH AND LOW CONDUCTANCE K-CHANNELS USING NON- EQUILIBRIUMMOLECULAR DYNAMICS. Fernando D. Gonzalez-Nilo , Romina Sepulveda, David Naranjo, Daniel Aguayo, Ingrid Araya, Ignacio Varas, Felipe Bravo, Ignacio Diaz-Franulic, Valeria Marquez-Miranda 2732-P os B oard #B424 2D IR AS AN EXPERIMENTAL PROBE OF ION-INDUCED STRUCTURAL CHANGES IN KCSA. Paul Stevenson , Christoph Götz, Carlos R. Baiz, Alipasha Vaziri, Andrei Tokmakoff

2707-P os B oard #B399 CALCIUM-ACTIVATED K CHANNEL REGULATES CELL VIABILITY IN HYPERKALEMIC AND HYPOKALEMIC CONDITIONS: IMPLICATION IN THE NEUROMUSCULAR DISODERS. Domenico Tricarico , Antonietta Mele, Sara Calzolaro, Giulia Maria Camerino, Diana Conte 2708-P os B oard #B400

STOCHASTIC MODELING OF CA 2+ -CHANNEL / BKCA-CHANNEL COMPLEXES. Daniel H. Cox 2709-P os B oard #B401

THE CYTOCHROME C-LIKE DOMAIN OF THE HUMAN BK CHANNEL. Taleh Yusifov , Roshni V. Madhvani, Riccardo Olcese 2710-P os B oard #B402 ENZYMATIC ACTIVITY OF THE HUMAN BK CHANNEL: A FUNCTION BEYOND ELECTRICAL SIGNALING. Taleh Yusifov , Nicoletta Savalli, Antonios Pantazis, Riccardo Olcese 2711-P os B oard #B403 BK β 1 TRANSMEMBRANE REGIONS CRITICALLY CONTROL THE CHARACTERISTIC PHENOTYPE OF β 1-CONTAINING BK CHANNEL CURRENTS. Guruprasad Kuntamallappanavar , Anna N. Bukiya, Alex M. Dopico 2712-P os B oard #B404 PHOSPHORYLATION OF A CONSTITUTIVE SERINE (S642) IN BK CHANNEL VARIANTS CONTAINING THE ALTERNATE EXON ‘SRKR’ ALTERS CURRENT PROPERTIES. Joshua P. Whitt, Chris Shelley, Andrea L. Meredith 2713-P os B oard #B405 UNCOVERING MITOBK CA CHANNEL MITOCHONDRIAL TRANSLOCATION MECHANISMS. Jin Zhang , Zhu Zhang, Enrico Stefani, Ligia Toro 2714-P os B oard #B406 PROTEOMIC ANALYSIS IDENTIFIES MAXIK CHANNEL INTRACELLULAR PARTNERS FROM HUMAN CORONARY ARTERY. Min Li , Zhu Zhang, Jure Marijic, Enrico Stefani, Ligia Toro 2715-P os B oard #B407 ALL-OR-NONE EFFECT OF γ 1 AUXILIARY SUBUNIT ON BK CHANNEL GATING. Vivian Gonzalez-Perez , Xiao-Ming Xia, Christopher Lingle 2716-P os B oard #B408 CYTOSOLIC ACTIVATION DYNAMICS IN THE KV CHANNEL PROBED BY A FLUORESCENT UNNATURAL AMINO ACID. Tanja Kalstrup , Rikard Blunck 2717-P os B oard #B409 OFFSETTING THE ELECTRIC FIELD SENSED BY K V CHANNELS THROUGH RESIDUE SUBSTITUTIONS ON TOP OF S1. Evelyn Martinez-Morales, Alain J. Labro , Dirk J. Snyders 2718-P os B oard #B410 ALLOSTERIC COUPLING OF THE INNER ACTIVATION GATE TO THE OUTER PORE OF A POTASSIUM CHANNEL. Chris Peters , David Fedida, Eric Accili 2719-P os B oard #B411 ENHANCEMENT OF C-TYPE INACTIVATION BY EXTERNAL CA 2+ AND LA 3+ . Clay M. Armstrong

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Biophysical Society 58 th Annual Meeting, San Francisco, California