BPS Program Book 2014

3337-P os B oard #B65 SOLID-STATE NMR CHARACTERIZATION OF S31N M2 TRANSMEMBRANE DOMAIN BOUND TO NOVEL ADAMAN- TANES WITH PERSISTENT IN VITRO EFFICACY. Anna K. Wright , Ivan Hung, Christina Tzitzoglaki, Harris Ioannidis, David D. Busath, Antonios Kolocouris, Timothy A. Cross 3338-P os B oard #B66 SINGLE MOLECULE FRET STUDIES OF THE NMDA RECEPTOR USING UNNATURAL AMINO ACIDS. Drew Dolino , David Cooper, Swarna Ramaswamy, Christy Landes, Vasanthi Jayaraman 3339-P os B oard #B67 HEME-TRANSFER MECHANISM OF STRUCTURALLY SIMILAR ISD NEAT DOMAINS OF STAPHYLOCOCCUS AUREUS EXHIBITING DIFFERENT AFFINITIES FOR HEME. Yoshitaka Moriwaki , Tohru Terada, Jose M. M. Caaveiro, Yousuke Takaoka, Itaru Hamachi, Kouhei Tsumoto, Kentaro Shimizu 3340-P os B oard #B68 EXPLORING HOW PHOSPHORYLATION INFLUENCES C-I IN- TERACTION AND CALCIUM SENSITIVITY OF TROPONIN BY MOLECULAR DYNAMICS SIMULATIONS. Yuanhua Cheng , Steffen Lindert, Peter Kekenes-Huskey, Vijay S. Rao, Paul R. Rosevear, J. Andrew McCammon, Andrew McCulloch, Michael Regnier 3341-P os B oard #B69 A COMPLETE CONFIGURATIONAL ENSEMBLE APPROACH TO EXPAND LSD1/COREST DRUGGABILITY. James C. Robertson , Nate C. Hurley, Julie M. Kneller, Nadeem A. Vellore, Andrea Mattevi, Riccardo Baron 3342-P os B oard #B70 THE ACIDIC RESIDUES OF THE I κ B α PEST SEQUENCE ARE RESPONSIBLE FOR “STRIPPING” NF κ B FROM DNA. Holly E. Dembinski , Elizabeth A. Komives 3343-P os B oard #B71 STRUCTURAL BASIS FOR CA 2+ SELECTIVITY OF A VOLTAGE- GATED CALCIUM CHANNEL. Lin Tang , Tamer M. Gamal El-Din, Jian Payandeh, Gilbert Q. Martinez, Teresa M. Heard, Todd Scheuer, Ning Zheng, William A. Catterall 3344-P os B oard #B72 STRUCTURAL AND DYNAMIC FEATURES UNDERLIE THE SWITCH OF LIGAND BINDING SPECIFICITY IN A TIAM1 PDZ DOMAIN MUTANT. Ernesto J. Fuentes , Xu Liu, David C. Speckhard, Tyson R, Shepherd 3345-P os B oard #B73 international travel awardee TRANSTHYRETIN INDUCED AMYLOIDOSIS INTERACTIONS, MECHANISMS AND POTENT DRUGS DESIGN. Rafal Jakubowski , Piotr Skrzyniarz, Lukasz Peplowski, Wieslaw Nowak 3346-P os B oard #B74 A TEMPERATURE JUMP RELAXATION STUDY OF DYNAMICS OF THERMOPHILIC LACTATE DEHYDROGENASE FROM TH. MARITIMA. Huo-Lei Peng , Hua Deng, Robert Callender 3347-P os B oard #B75 STRUCTURAL AND FUNCTIONAL BASIS OF TOLLIP ASSOCIATION TO THE ENDOSOMAL ADAPTOR PROTEIN TOM1. Mary K. Brannon , Shuyan Xiao, Geoffrey Armstrong, Kristen Fread, Carla V. Finkielstein, Daniel G. S. Capelluto 3348-P os B oard #B76 MODELING AND EXPERIMENTAL STUDY OF NHERF1 PDZ DOMAIN SPECIFICITY. Tatyana Mamonova , Alessandro Bisello, Peter A. Friedman

3325-P os B oard #B53 EXPLORING THE ENERGY LANDSCAPE THROUGH ANCESTRAL PROTEINS. Shion An , Kathryn M. Hart, Susan Marqusee 3326-P os B oard #B54 THE EFFECTIVE TEMPERATURE OF MUTATIONS: A GENERAL MECHANISM FOR THE CONGRUENT EVOLUTION OF ROBUSTNESS. Gergely J. Szöllősi , Imre Derényi 3327-P os B oard #B55 MOONLIGHTING PROTEINS. Constance Jeffery , Matt Mani, Vaishak Amblee, Chang Chen Dynamics of Ligand Binding (Boards #B56–#B84) 3328-P os B oard #B56 THIOL LABELING REVEALS PRESENCE OF CRYPTIC BINDING SITES IN BETA-LACTAMASE. Eric Bolin , Brendan Maguire, Gregory Bowman, Susan Marqusee 3329-P os B oard #B57 STRUCTURAL DYNAMICS STUDIES OF FATTY ACID BINDING PROTEIN-4 BY SOLUTION NMR SPECTROSCOPY. Adedolapo Ojoawo, Choua Xiong , Kim N. Ha 3330-P os B oard #B58 minority affairs travel awardee INSIGHTS INTO THE CYCLIC NUCLEOTIDE SELECTIVITY MECHANISM OF CYCLIC GMP DEPENDENT PROTEIN KINASE II. James Campbell , Gilbert Huang, Albert Reger, Todd Link, John Ladbury, Choel Kim 3331-P os B oard #B59 EFFECTS OF LIGAND BINDING ON THE RIGIDITY AND MOBILITY OF PROTEINS: AN EXPERIMENTAL AND COMPUTATIONAL APPROACH. Jack Heal , Claudia Blindauer, Robert B. Freedman, Rudolf Roemer 3332-P os B oard #B60 BRIDGING SIMULATIONS AND CALORIMETRY: COMPUTATIONAL STUDIES OF BINDING THERMODYNAMICS AND ENTROPY-ENTHALPY TRANSDUCTION. Michael K. Gilson , Andrew T. Fenley, Hari Muddana 3333-P os B oard #B61 DIFFERENTIAL RESPONSES OF MSH2/6 AND DAMAGED DNA PROBED BY MOLECULAR DYNAMICS. Freddie R. Salsbury, Jr , Lacramioara Negureanu 3334-P os B oard #B62 ATOMIC RESOLUTION MECHANISM OF CD44-HYALURONAN PROTEIN-CARBOHYDRATE BINDING. Christina E. Faller, Amanda J. Favreau, Olgun Guvench 3335-P os B oard #B63 A MOLECULAR DYNAMICS INVESTIGATION OF THE BACTERIAL CIS-PRENYL TRANSFERASES: PERSPECTIVES ON CONFORMATIONAL FLEXIBILITY AND CHAIN ELONGATION MECHANISMS. Meekyum O. Kim , Ferran Feixas-Gerones, Eric Oldfield, J. Andrew McCammon 3336-P os B oard #B64 STUDY OF THE DYNAMIC AND THERMODYNAMIC CALCIUM INDUCED TRANSITION IN THE DOWNSTREAM REGULATORY ELEMENT ANTAGONIST MODULATOR (DREAM) USING PHOTOTHERMAL BEAM DEFLECTION (PBD). Walter G. Gonzalez , Jaroslava Miksovska

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Biophysical Society 58 th Annual Meeting, San Francisco, California