BPS Program Book 2014

3909-P os B oard #B637 FUNCTIONAL ADAPTATIONS TO CARDIAC TROPONIN I PHOSPHOMIMETIC SUBSTITUTIONS. Sarah E. Lang , Margaret V. Westfall 3910-P os B oard #B638 cpow travel awardee MYOSIN HEAVY CHAIN ISOFORM SWITCHING IN SKELETAL MUSCLES IN AN A8V-TROPONIN C HYPERTROPHIC CARDIOMYOPATHY KNOCK-IN MOUSE MODEL. Milica Vukmirovic , Marcos A. Sanchez-Gonzalez, Edda Ruiz, Eric Krivensky, David Dweck, Jose R. Pinto 3911-P os B oard #B639 CARDIAC MYOSIN BINDING PROTEIN-C PHOSPHORYLATION AND SARCOMERE FUNCTION. Mohit Kumar , Suresh Govindan, Sakthivel Sadayappan, Pieter P de Tombe 3912-P os B oard #B640 EFFECT OF A HIGH-SALT DIET ONTHE MECHANO-ENERGETICS OF LEFT VENTRICULAR TRABECULAE ISOLATED FROM DAHL SALT-SENSITIVE RATS. Kenneth Tran , June-Chiew Han, Carolyn J. Barrett, Andrew J. Taberner, Denis S. Loiselle, Edmund J. Crampin 3913-P os B oard #B641 OXYGEN CONSUMPTION OF BROWN ADIPOSE TISSUE (BAT) AND SKELETAL MUSCLE IS INVERSELY RELATED. Cecilie Sjåland, Jan Magnus Aronsen, Madelene Ericsson, Hong Qu, Øyvind Ellingsen, Ivar Sjaastad, Geir Christensen, Kristin B. Andersson, Per K. Lunde , Ole M. Sejersted 3914-P os B oard #B642 OPTOGENETIC G S ACTIVATION IN CARDIOMYOCYTES ENHANCES PACEMAKER ACTIVITY. Philipp Makowka , Tobias Bruegmann, Thomas Beiert, Philipp Sasse 3915-P os B oard #B643 COMPARTMENTATION OF CAMP SIGNALING IN COMPLEX AND SIMPLE CELLS. Shailesh R. Agarwal , Pei-Chi Yang, Colleen Clancy, Robert Harvey 3916-P os B oard #B644 UPREGULATION OF α 1-ADRENERGIC INOTROPY IN FAILING RIGHT VENTRICLE (RV) IS MEDIATED BY THE α 1A SUBTYPE. Patrick M. Cowley , Om Makwana, Audrey N. Chang, Paul C. Simpson, James T. Stull, Anthony J. Baker 3917-P os B oard #B645 CARDIAC-SPECIFIC OVEREXPRESSION OF FOXO AFFORDS PROTECTION AGAINST AGE-ASSOCIATED DECLINE IN CARDIAC PERFORMANCE IN THE DROSOPHILA MODEL. Anna Blice-Baum , Guarav Kaushik, Meera C. Viswanathan, Rolf Bodmer, Adam J. Engler, Anthony Cammarato 3918-P os B oard #B646 MYOSIN STORAGE MYOPATHY MUTATIONS DISRUPT MYOFIBRILLAR ASSEMBLY/ STABILITY AND CAUSE PROGRESSIVE MUSCLE DEGENERATION IN A DROSOPHILA MODEL. Meera Cozhimuttam Viswanathan , William A. Kronert, Girish C. Melkani, Anthony Cammarato, Sanford I. Bernstein 3919-P os B oard #B647 EFFECTS OF FHC-RELATED TROPONIN T MUTATIONS ON PROTEASOME ACTIVITY AND HALF-LIFE OF TROPONIN T. Jennifer E. Gilda , Ziyou Cui, Aldrin V. Gomes 3920-P os B oard #B648 MIRNA-448 IS A PRECURSOR OF ROS-DERIVED DYSTROPHIC CARDIOMYOPATHY. Sergii Kyrychenko, Viktoriia Kyrychenko, Yoshiyuki Ikeda, Junichi Sadoshima, Natalia Shirokova

3897-P os B oard #B625 INVOLVEMENT OF TRPC IN THE SLOW FORCE RESPONSE OBSERVED IN MOUSE VENTRICULAR MYOCYTES. Yohei Yamaguchi , Toshiyuki Kaneko, Keiji Naruse, Gentaro Iribe 3898-P os B oard #B626 HYPERCHOLESTEROLEMIA PROTECTS AGAINST ISCHEMIA-INDUCED VENTRICULAR TACHYCARDIA AND VENTRICULAR FIBRILLATION. Antonius Baartscheer , Cees A. Schumacher, Marieke W. Veldkamp, Arie O. Verkerk, Ruben Coronel 3899-P os B oard #B627 APICO-BASAL GRADIENT OF REPOLARIZATION OVER THE LEFT VENTRICLE DETERMINES ARRHYTHMIA SUSCEPTIBILITY INMICE. Morten B. Thomsen , Tobias Speerschneider, Søren Grubb, Søren-Peter Olesen, Kirstine Calloe 3900-P os B oard #B628 EFFECT OF DIFFERENT CURRENTS AND EXTRACELLULAR POTASSIUM ION CONCENTRATION ON ANODAL EXCITATION OF CARDIAC TISSUE. Sunil M. Kandel , Bradley J. Roth 3901-P os B oard #B629 EXAMINATION OF THE HEAT-STRESS RELATIONSHIP OF RAT CARDIAC TRABECULAE USING AN IMPROVED MUSCLE CALORIMETER. Callum M. Johnston , June-Chiew Han, Bryan P. Ruddy, Poul M.F. Nielsen, Andrew J. Taberner 3902-P os B oard #B630 SARCOMERE LENGTH NANOMETRY IN CARDIOMYOCYTES EXPRESSEDWITH α -ACTININ-ACGFP IN Z-DISCS. Seine A. Shintani , Kotaro Oyama, Takashi Ohki, Shin’ichi Ishiwata, Norio Fukuda 3903-P os B oard #B631 DETERMINING THE MOLECULAR MECHANISMS THAT LINK A TITIN MUTATION TO CARDIOMYOPATHY. Brian Anderson , Julius Bogomolovas, Siegfried Labeit, Henk Granzier 3904-P os B oard #B632 CARDIAC MYOFILAMENT SARCOMERE SHORTENING IS FASTER AND EXHIBITS GREATER SHORTENING-INDUCED COOPERATIVE DEACTIVATION AFTER PKA TREATMENT. Laurin M. Hanft , Kerry S. McDonald 3905-P os B oard #B633 THE EFFECT OF α -ACTIN MUTANT E361G ON FORCE GENERATION AND CROSS-BRIDGE KINETICS IN THIN-FILAMENT RECONSTITUTED BOVINE CARDIAC MUSCLE FIBERS. Fan Bai, Hannah M. Caster, John F. Dawson, Masataka Kawai 3906-P os B oard #B634 THE ACTC A295S MUTATION INCREASES HEART AND SKELETAL MUSCLE CONTRACTILE ACTIVITY IN DROSOPHILA MODELS OF HYPERTROPHIC CARDIOMYOPATHY. Meera C. Viswanathan, Bernadette M. Glasheen, Kaylyn Bell, Douglas M. Swank, Anthony Cammarato 3907-P os B oard #B635 DCM-CAUSING MUTATION E361G IN ACTIN UNCOUPLES MYOFIBRIL CA 2+ SENSITIVITY FROM PROTEIN PHOSPHORYLATION. Petr G. Vikhorev, Ross Wilkinson, Weihua Song, O’Neal Copeland, Michael A. Ferenczi, Steven B. Marston 3908-P os B oard #B636 SARCOMERE NEUTRALIZATION THERAPY IN HCM/RCM: THERAPEUTIC APPLICATION OF THE CALCIUMDESENSITIZER W7 TO REMEDIATE HYPER-CALCIUM SENSITIVE DISEASE STATES. Brian R. Thompson , Joshua Martindale, Joseph M. Metzger

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Biophysical Society 58 th Annual Meeting, San Francisco, California