BPS Program Book 2014

680-P os B oard #B435 AUTOMATED PATCH CLAMPING OF 384 CELLS AT ONCE FOR MASSIVELY PARALLEL ION CHANNEL SCREENING. Andrea Bruggemann , Claudia Haarmann, Timo Stengel, Marius Vogel, Juergen Steindl, Max Mueller, Johannes Stiehler, Michael George, Niels Fertig 681-P os B oard #B436 SODIUM CHANNEL PEPTIDE NEUROTOXIN STUDIES USING A HIGH THROUGHPUT ELECTROPHYSIOLOGY PLATFORM AND VERY LONG ASSAY WINDOWS. Xin Jiang , Jeffrey Webber, Trisha Mitlo, Edward Verdonk, James Costantin 682-P os B oard #B437 SEARCHING FOR THE INTERACTION SITES OF THE BETA1 SUBUNIT WITH THE VOLTAGE-SENSING DOMAINS OF SODI- UM CHANNELS USING LRET. Tomoya Kubota , Bobo Dang, Rocio K. Finol-Urdaneta, Jérôme J. Lacroix, Ludivine Frezza, Robert J. French, Stephen B. H. Kent, Ana M. Correa, Francisco Bezanilla 683-P os B oard #B438 TRACKING VOLTAGE-DEPENDENT CONFORMATIONAL CHANGES OF THE VSD IN NAV WITH LRET. Tomoya Kubota , Pedro Brugarolas, Bobo Dang, Rocio K. Finol-Urdaneta, Ludivine Frezza, Robert J. French, Stephen B. H. Kent, Francisco Bezanilla, Ana M. Correa Voltage-gated Ca Channels I (Boards #B439–#B456) 684-P os B oard #B439 OBSERVATION OF “REMOTE KNOCK-ON”, A NEW PER- MEATION-ENHANCEMENT MECHANISM IN ION CHAN- NELS. Dmitry G. Luchinsky , Rodrigue Tindjong, Igor Kaufman, Peter V. E. McClintock, Igor A. Khovanov, Bob S. Eisenberg 685-P os B oard #B440 A MUTATIONAL AND COMPUTATIONAL STUDY OF WATER AND ION MOVEMENT THROUGH THE S6 BUNDLE-CROSS- ING OF CAV1.2 CHANNEL. Roman Shirokov 686-P os B oard #B441 POISSON-FERMI MODEL OF A CALCIUM CHANNEL: CORRE- LATIONS AND DIELECTRIC COEFFICIENT ARE COMPUTED OUTPUTS. Bob Eisenberg , Jinn-Liang Liu 687-P os B oard #B442 THE FUNCTIONAL HETEROGENEITY OF THE HUMAN CA V 1.2 VOLTAGE SENSORS. Antonios Pantazis , Nicoletta Savalli, Daniel Sigg, Alan Neely, Riccardo Olcese 688-P os B oard #B443 FUNCTIONAL INTERACTION BETWEEN THE N-TERMINI OF MURINE L-TYPE CALCIUM CHANNEL CA V 1.2- AND β -SUBUNIT SPLICE VARIANTS. Ajay K. Singh, Elza Kuzmenkina, Jan Matthes, Stefan Herzig 689-P os B oard #B444 GATING PROPERTIES OF CAV1.3 CALCIUM CHANNELS: IN- SIGHT FROM ALTERNATIVE SPLICING AND HUMAN MUTA- TIONS. Andreas Lieb , Nadine Ortner, Alexandra Pinggera, Elena A. Azizan, Morris J. Brown, Petronel Tuluc, Jörg Striessnig 690-P os B oard #B445 HILL ANALYSIS OF ION CHANNEL ACTIVATION: THEORY AND PRACTICE. Daniel Sigg , Ru-Chi Shieh, Antonios Pantazis, Nicoletta Savalli, Riccardo Olcese

691-P os B oard #B446 DOMAIN-SPECIFIC GATING-MODIFIER TOXINS FOR VOLTAGE-GATED CALCIUM CHANNELS. Autoosa Salari , Vincent L. Baggett, Mirela Milescu 692-P os B oard #B447 THE α 2 δ SUBUNIT FACILITATES CA V 1.2 CHANNEL ACTIVATION BY REMODELING ITS FOUR VOLTAGE SENSOR DOMAINS. Nicoletta Savalli , Antonios Pantazis, Daniel Sigg, Alan Neely, Riccardo Olcese 693-P os B oard #B448 A POPULATION DENSITY AND MOMENT-BASED APPROACH TO MODELING DOMAIN CALCIUM-MEDIATED INACTIVATION OF L-TYPE CALCIUM CHANNELS. Xiao Wang , Kiah Hardcastle, Seth H. Weinberg, Gregory D. Smith 694-P os B oard #B449 MINIMIZED CELL USAGE FOR STEM CELL-DERIVED AND PRIMARY CELLS ON AN AUTOMATED PATCH CLAMP SYSTEM. Nadine Becker, Sonja Stoelzle-Feix, Sven Goepel, David Guinot, Patrick Mumm, Claudia Haarmann, Daniela Malan, Heribert Bohlen, Eugen Kossolov, Ralf Kettenhofen, Michael George, Niels Fertig, Andrea Bruggemann 695-P os B oard #B450 TESTING FOR DIRECT INTERACTIONS BETWEEN THE DHPR AND THE RYR1 CYTOPLASMIC FOOT. Hicham Bichraoui , Ong Moua, Alexander Polster, Tsutomu Tanabe, Simon Papadopoulos, Kurt G. Beam 696-P os B oard #B451 MULTIPLE REGIONS INHIBIT EXPRESSION OF CAV1.1 CA 2+ CHANNELS IN NON-MUSCLE CELLS. Alexander Polster , Tsutomu Tanabe, Ong Moua, Kurt G. Beam 697-P os B oard #B452 RESIDUES CRITICAL FOR VOLTAGE-SENSOR TRANSITIONS DETERMINING GATING PROPERTIES OF CAV1.1. Petronel Tuluc , Vladimir Yarov-Yarovoy, Bruno Benedetti, Bernhard E. Flucher 698-P os B oard #B453 DIFFERENTIAL STABILITY OF CA V β 2A AND CA V β 3 IN A CA V 1.2 CALCIUM CHANNEL COMPLEX. Marta Campiglio , Felix Findeisen, Hyunil Jo, William F. DeGrado, Daniel L. Minor, Jr., Bernhard E. Flucher 699-P os B oard #B454 THE AMINO-TERMINI OF RGK PROTEINS DICTATE THE MODE OF L-TYPE CA 2+ CHANNEL INHIBITION IN ADULT SKELETAL MUSCLE. Donald Beqollari , Christin F. Romberg, Ulises Meza, Symeon Papadopoulos, Roger A. Bannister 700-P os B oard #B455 PEGYLATED-CHOLESTEROL DECREASES THE AMPLITUDE AND AUGMENTS TIME- AND VOLTAGE-DEPENDENT INACTIVATION OF L-TYPE CA 2+ CURRENT OF A7R5 CELLS FROM RAT AORTA. Rikuo Ochi , Sukrutha Chettimada, Sachin A. Gupte 701-P os B oard #B456 AKAP79/150-ANCHORED CAN AND PKA REGULATE NEURONAL L-TYPE CALCIUM CHANNEL ACTIVITY AND NFAT TRANSCRIPTIONAL SIGNALING. Jonathan G. Murphy , Mark L. Dell’Acqua

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Biophysical Society 58 th Annual Meeting, San Francisco, California