BPS Program Book 2014

1239-P lat 4:15 pm LIGHT-POWERED BIONANOELECTRONIC DEVICES WITH BIOLOGICALLY-TUNABLE PERFORMANCE CHARACTERISTICS. Ramya Tunuguntla , Kyunghoon Kim, Mangesh Bangar, Caroline Ajo-Franklin, Pieter Stroeve, Aleksandr Noy 1240-P lat 4:30 pm LIGHT DRIVEN CONFORMATIONAL SWITCHING: AN APPROACH TO CREATING DESIGNED PROTEIN MOTION. Elizabeth Bromley , Lara Small, Asahi Cano-Marques, Dek Woolfson, Paul Curmi, Martin Zuckermann, Nancy Forde, Gerhard Blab, Heiner Linke 1241-P lat 4:45 pm HIGH THROUGHPUT LIVE-CELL FRET BINDING ASSAY BY FLOW CYTOMETRY. Shin Rong Lee , Lingjie Sang, David T. Yue 1242-P lat 5:00 pm QUANTIFYING CELL-SURFACE MARKER EXPRESSION THROUGH IMAGING OF TRANSIENT INTERACTIONS. Mustafa A. H. Mir , Olivia Scheideler, Jeremy Whang, Lydia L. Sohn 1243-P lat 5:15 pm SORTING BACTERIUM CELLS USING CELL-IMPRINTED POLYMER THIN FILMS: FROM CONCEPT TO APPLICATIONS. Kangning Ren , Niaz Banaei, Richard N. Zare 1244-P lat 5:30 pm PATIENT-SPECIFIC IPSCS-BASED LIVER-ON-A-CHIP. SoonGweon Hong , Luke P. Lee 1245-P lat 5:45 pm A BIOPHYSICAL SOLUTION TO PREVENT HEMOLYSIS |INTERFERENCES. Jun Ho Son , Sang Hun Lee, Soongweon Hong, Seung-min Park, Joseph Lee, Andrea M. Dickey, Luke P. Lee Co-Chairs Tania Baker, Massachusetts Institute of Technology Susan Marqusee, University of California, Berkeley 1246-P lat 4:00 pm EXPERIMENTAL AND COMPUTATIONAL STUDIES ON THE DYNAMICS AND FLEXIBILITY OF PROTEIN DISULFIDE-ISOMERASE (PDI). Robert B. Freedman , John Blood, David Clarke, Jack Heal, Emilio Jimenez-Roldan, Rudolf Roemer, Narinder Sanghera 1247-P lat 4:15 pm OBSERVING AND CHARACTERIZING EARLY FOLDING INTERMEDIATES OF E.COLI RNASE H USING KINETIC AND EQUILIBRIUM APPROACHES. Laura E. Rosen , Sagar Kathuria, Katelyn Connell, Osman Bilsel, C. Robert Matthews, Susan Marqusee 1248-P lat 4:30 pm MECHANICAL PROTEIN UNFOLDING AND TRANSLOCATION BY AAA+ PROTEASES. Adrian O. Olivares , Juan Carlos Cordvoa, Stephane Calmat, Matthew J. Lang, Robert T. Sauer, Tania A. Baker 1249-P lat 4:45 pm THE CLPXP PROTEASE EMPLOYS A NOVEL MECHANISM OF TRANSLOCATION USING A CONSTANT FREQUENCY OF PULLING BUT DIFFERENT GEARS. Maya Sen , Rodrigo A. Maillard, Kristofor Nyquist, Piere Rodriguez-Aliaga, Steve Pressé, Andreas Martin, Carlos Bustamante 4:00 pm –6:00 pm , R oom 304 Platform Protein Folding and Chaperones

4:00 pm –6:00 pm , R oom 132/133 Platform Cell Mechanics and Motility II

M O N D A Y

Co-Chairs Jin-Sung Park, Korea Advanced Institute of Science and Technology, Korea Pietro Cicuta, University of Cambridge, United Kingdom 1230-P lat 4:00 pm MECHANISMS OF THREE-DIMENSIONAL TUMOR CELL MOTILITY IN DENSE EXTRACELLULAR MATRICES. Badriprasad Ananthanarayanan , Joanna MacKay, Gurshamnjot Singh, Ching-Wei Chang, Sanjay Kumar 1231-P lat 4:15 pm TRANSDUCTION CHANNELS’ GATING CONTROLS FRICTION ONVIBRATINGHAIR-CELL BUNDLES INTHE EAR. Volker Bormuth , Jérémie Barral, Jean Francois Joanny, Frank Jülicher, Pascal Martin 1232-P lat 4:30 pm EMERGENCE OF COLLECTIVE DYNAMICS IN SYSTEMS OF MOTILE CILIA. Pietro Cicuta , Nicolas Bruot, Jurij Kotar, Luke Debono, Dave Phillips, Stuart Box, Stephen Simpson, Simon Hanna 1233-P lat 4:45 pm CHARACTERIZATION OF DIFFERENT DYNAMIC MODES OF A CRAWLING CAENORHABDITIS ELEGANS BY DIRECT MEASUREMENT OF TRACTION FORCE. Jin-Sung Park , Song Ih Ahn, Jennifer H. Shin 1234-P lat 5:00 pm OPTIMALITY OF FORCE TRANSMISSION IN A MOTOR-CLUTCH CELLULAR ADHESION MODEL. Benjamin Bangasser , Steven Rosenfeld, David Odde 1235-P lat 5:15 pm FORCE SPECTRUM MICROSCOPY REVEALS ACTIVE DIFFUSIVE-LIKE FLUCTUATIONS IN LIVING CELLS. Ming Guo , Allen Ehrlicher, Mikkel Jensen, Jeffrey Moore, Jennifer Lippincott-Schwartz, Frederick Mackintosh, David Weitz 1236-P lat 5:30 pm MYOSIN LIGHT CHAIN KINASE ACTIVITY REGULATES THE NUMBER OF LEADING EDGES IN ZEBRAFISH EMBRYONIC KERATOCYTES. Sunny S. Lou , Julie A. Theriot 1237-P lat 5:45 pm QUANTITATIVE SUBCELLULAR CONTROL OF CDC42, RAC1 AND RHOA GTPASES USING THE CRY2/CIBN OPTOGENETIC DIMERIZER. Leo Valon , Amanda Remorino, Fred Etoc, Simon De Beco, Maxime Dahan, Mathieu Coppey

4:00 pm –6:00 pm , R oom 303 Platform Bioengineering

Co-Chairs Elizabeth Bromley, Durham University, United Kingdom SoonGweon Hong, University of California, Berkeley 1238-P lat 4:00 pm

BIOMECHANICAL BASIS OF ALZHEIMER’S DISEASE AND OTHER PROTEIN MISFOLDING DISEASES: DESIGNING A NEW AFM PROBE TO STUDY AMYLOID-MEDIATED MEMBRANE DISORDERS. Amanda K. Woodcock , Brian Meckes, Ratnesh Lal

75

Biophysical Society 58 th Annual Meeting, San Francisco, California