BPS Program Book 2014

1367-P os B oard #B97 LONG-RANGE DISTANCE CONSTRAINTS FOR THE FIBRIL FOLD OF PARKINSON’S PROTEIN ALPHA-SYNUCLEIN. Maryam Hashemi Shabestari, Pravin Kumar, Ine M.J. Segers-Nolten, Mireille M.A.E. Claessens, Bart D. van Rooijen, Vinod Subramaniam, Martina Huber 1368-P os B oard #B98 STRUCTURE OF THE TRANSIENT, MEMBRANE-ACTIVE AMYLOID BETA OLIGOMERS IN PHYSIOLOGICAL SOLUTIONS PROBED BY A COMBINATION OF FLUORESCENCE AND SOLID STATE NMR. Bappaditya Chandra , Bidyut Sarkar, Venus Singh, Arghya Mandal, Muralidharan Chandrakesan, Perunthiruthy K. Madhu, Sudipta Maiti 1369-P os B oard #B99 SYSTEMATIC CHARACTERIZATION OF WILD TYPE AND FAMILIAL ALZHEIMER’S DISEASE MUTANT A β MONOMERS THROUGH THE CONVERGENCE OF ENSEMBLES SIMULATED WITH DIFFERENT FORCE FIELDS. David J. Rosenman , Nicolina Clemente, Chunyu Wang, Angel E. García 1370-P os B oard #B100 STRUCTURAL AND MECHANISTIC ANALYSES OF THE EFFECTS OF SMALL COMPOUNDS ON AMYLOID BETA SELF-ASSEMBLY. Johnny Habchi , Priyanka Joshi, Alessandro Spilotros, Dmitri Svergun, Michele Vendruscolo 1371-P os B oard #B101 international travel awardee DECOUPLING CONFORMATION, AGGREGATION AND FUNCTION OF AMYLOID- β MONOMERS AND OLIGOMERS: AN FCS, SERS AND AFM STUDY. Debanjan Bhowmik , Christina MacLaughlin, Gilbert C. Walker, Sudipta Maiti 1372-P os B oard #B102 TRANSTHYRETIN INTERACTS WITH AMYLOID- Β ETA OLIGOMERS TO DELAY AMYLOID AGGREGATION. Kanchan Garai , Xinyi Li, Evan M. Powers, Joel Buxbaum, Rohit Pappu 1373-P os B oard #B103 AMYLIN INTERACTS WITH A β AND MAY ACCELERATE THE DEVELOPMENT OF DEMENTIA. Kaleena Jackson, Simon Xie, Florin Despa 1374-P os B oard #B104 MAPPING THE STRUCTURE OF TAU USING SINGLE MOLECULE FRET. Xiaohan Li , Elizabeth Rhoades 1375-P os B oard #B105 EXPLORING A TWO-STEP ADSORPTION OF AN INTRINSICALLY DISORDERED PEPTIDE AT MODEL TEMPLATES. Prajnaparamita Dhar , Jordan Hildenbrand 1376-P os B oard #B106 INCREASED AFFINITY FOR TUBULIN IMPAIRS TAU FUNCTION. Elizabeth Rhoades , Shana Elbaum-Garfinkle, Garrett Cobb, Jocelyn T. Compton, Xiaohan Li 1377-P os B oard #B107 education travel awardee STATHMIN EXISTS AS AN OLIGOMER IN SOLUTION, AS EVIDENCED BY STATIC LIGHT-SCATTERING, NATIVE GEL ELECTROPHORESIS, AND EPR SPECTROSCOPY. Ashley J. Chui , Katherina C. Chua, Michael D. Bridges 1378-P os B oard #B108

1379-P os B oard #B109 SOLVENT EFFECTS ON THE STRUCTURE AND INTERNAL DYNAMICS OF CALCITONIN GENE-RELATED PEPTIDE. Sara M. Sizemore , Stephanie M. Cope, Anindya Roy, Giovanna Ghirlanda, Sara M. Vaiana 1380-P os B oard #B110 MOLECULAR CROWDING STABILIZES BOTH THE INTRINSICALLY DISORDERED CALCIUM-FREE STATE AND THE FOLDED CALCIUM-BOUND STATE OF AN RTX PROTEIN: IMPLICATION FOR TOXIN SECRETION. Ana Cristina Sotomayor Pérez, Orso Subrini, Audrey Hessel, Daniel Ladant, Alexandre Chenal 1381-P os B oard #B111 STRUCTURAL ENSEMBLES OF INTRINSICALLY DISORDERED PROTEINS DEPEND STRONGLY ON FORCE FIELD. Sarah Rauscher , Vytautas Gapsys, Andreas Volkhardt, Christian Blau, Bert L. de Groot, Helmut Grubmüller DNA Replication and Dynamics (Boards #B112–#B127) 1382-P os B oard #B112 REPLICATIVE HELICASE ASSISTS DNA POLYMERASE IN BYPASSING A LESION. Bo Sun , James T. Inman, Benjamin Y. Smith, Yi Yang, Smita S. Patel, Michelle D. Wang 1383-P os B oard #B113 DNA UNWINDING BY PCRA HELICASE AND REPD USING TIRF AND MAGNETIC TWEEZERS. Algirdas Toleikis, Simone Kunzelmann, Gregory I. Mashanov, Martin R. Webb, Justin E. Molloy 1384-P os B oard #B114 SINGLE MOLECULE STUDY OF HIV-1 REVERSE TRANSCRIPTASE POLYMERIZATION ACTIVITY IN THE PRESENCE OF NC. Kiran Pant , Robert J. Gorelick, Ioulia Rouzina, Mark C. Williams 1385-P os B oard #B115 A NOVEL FUNCTION OF THE BACTERIAL REPLICATION INITIATOR PROTEIN DNAA. Paola E. Mera , Virginia Kalogeraki, Lucy Shapiro 1386-P os B oard #B116 DYNAMICS OF DSDNA BREAK, ORGANIZATION OF THE NUCLEUS BASED ON POLYMER DYNAMICS. David Holcman , Assaf Amitai 1387-P os B oard #B117 DNA SECONDARY STRUCTURE FORMATION IN BACTERIAL GENE CAPTURE SYSTEMS AT SINGLE-MOLECULE RESOLUTION. Marko Swoboda, Maj Svea Grieb, Varsha Natarajan, Aleksandra Nivina, Didier Mazel, Michael Schlierf 1388-P os B oard #B118 INVESTIGATING THE DYNAMICS OF THE β 2 SLIDING CLAMP IN ESCHERICHIA COLI AT THE SINGLE-CELL LEVEL UTILIZ- ING SINGLE-MOLECULE FLUORESCENCE MICROSCOPY. SriramTiruvadi Krishnan , Martin Charl Moolman, JacobW.J. Kerssemakers, Theo van Laar, Pawel Tulinski, Rodrigo Reyes-Lamothe, David J. Sherratt, Nynke H. Dekker 1389-P os B oard #B119 SV40 HELICASE UNWINDS DNA AGAINST FORCE. Mariana Koeber , Zhongbo Yu, Kollol Aguan, Bojk Berghuis, David Dulin, Nynke H. Dekker

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GLI3/SPOP MULTIVALENT INTERACTIONS ARE CONCENTRATION-DEPENDENT. Melissa R. Marzahn , Tanja Mittag

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Biophysical Society 58 th Annual Meeting, San Francisco, California